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The map label for this gene is ppx [H]

Identifier: 124022369

GI number: 124022369

Start: 620151

End: 621797

Strand: Direct

Name: ppx [H]

Synonym: P9303_06591

Alternate gene names: 124022369

Gene position: 620151-621797 (Clockwise)

Preceding gene: 124022366

Following gene: 124022377

Centisome position: 23.12

GC content: 54.58

Gene sequence:

>1647_bases
TTGCCTTTCGGTGTGGTTGATGTCGAGCAGGAGGAGGCCAGGTACGCCAGTGCTGGTCAGCTCCGTTCTGAGCGAGAGCT
CCGCAATGTTGCTGCGATTGATATTGGAACCAATTCCACCCATCTCCTGGTGGCGTCGGTTGATCCTTCTCTGCACACCT
TCAGCGTTGATCTTGCAGAGAAATCAACCACAAGACTGGGTGAGCGAGACCCTGACTCTGGAGAGCTCACGGGTCCTGCT
ATGGAGCGGGTATTTGAAACACTCAAACGTTTTAAGGAGCTAGCCGCCAGCCACCAGGTGGAGCAGGTGGTTGCGTCGGC
GACTAGCGCAGTACGTGAAGCTTCAAATGGGCGAGATTTTTTGCAACGGATTCAGGATCAGCTCGGCCTTGAGGTGGATC
TGTTGAGCGGTGCTGAGGAAGCACGACTGATCTATTTGGGTGTTTTGTCTGGCATGCCTTTTGGGGAGTGTCCCCATCTT
TTGCTCGATATCGGTGGCGGGTCCACAGAGCTCATCCTCGCGGATGGTCGCGATGCTCGGGCTCTGACAAGCACGCGGGT
TGGTGCGGTTCGGCTACAGAGGGATTTTGTCAAGCATGAACCAATCCCCCCTCAACGGCGTTCCTTTTTGCAGACATTTA
TCCAGGGTTCTTTAGAGCCAGCTGTTGATAAGGTCTGCCGTCGCATCAATCCTGGGGAGAGCCCTGTGATGGTTGCCACC
AGTGGAACCGCCATGGCCATCGGTGCTTTGTTGGCTAGCGAAGATGATCGCCCTCCGTTGAGATTGCATGGCTATCGATT
CTCACGGCAGCGGCTTGATGGCCTGGTTGAGAAGCTGATAGCGATGACGCCTGAGCAGCGTCGCATCCAGACGCCGATTA
ATGATCGCCGTTCCGAAATCATCGTTCCGGGTGCGCTGATTCTTCAAACCGCCATGCAGATGCTCGCTGCTGATGAGCTG
GTGCTGAGTGAAAGGGCTCTGAGGGAGGGTTTGATCGTTGACTGGATGCTGCGACACGGCCTACTGGAGGATCGCTTTAG
TTTTCAGAGCAGTATTCGTCAGCGCACCGTGATTCATCAGGTGCAGCGTTTTGCAGTGAATCACCGCCGTGCAGAGCGTG
TAGCCAGCCATGCACTCAGCCTTTACGACCACACACATGGTGTTCTTCATCACGATGATGGAGGTGGTCGGGATCTGCTT
TGGGCATCGGCAATGTTGCATGCCTGTGGTCAGCACATCAATCTCAGTGCTTATCACAAGCATTCCTGGTATCTGATTCG
TCATGGCGAGTTGCTCGGCTATTCGGAAGCGGAGCATTTGATGGTTGCGGCTATTGCGCGCTATCACCGCCGCAGTCTTC
CCAAGAAGCGCCATCTGGAATGGCAGGCTTTGGCCACCCGGGAGCATCGTCGTCTCGTTGCCGAGATGGCTTTGTTGCTG
CGATTAGCAGCAGCCATTGATCGTCGTCCTGAGCCAGTGGTGGCTGCAATCAGAGTGGAGTCCGCTGATGATGATCAGGT
TGTCTTTGAACTCGTGCCGGAAGGATTGAATCAGAACCTCAGCCTTGAACAATGGAGCTTGAAGAGCTGTGCTTCGGTTG
TGAAAGAAGCAAGCGGCGTAACCATGAAAGTTGTCGTTGAGGAATGA

Upstream 100 bases:

>100_bases
TGGGTTTGAAGAACCCTAGGGAGGGACCTCCAGACATCGTTGGCTGATGGCAAAGTGGTCTCGTTCCAGGCTCCTGTACT
TCATGCCAGGTGTCGAGCCA

Downstream 100 bases:

>100_bases
ACTTAGTTCAGCATTAGGTTGTTGTTGTTGTTGGTTAATTGATGCCAGTGGATCTTTCTGATTTTGCCCAGAGCAGTAGG
CGGTTTTCGATTATGAGTTA

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MPFGVVDVEQEEARYASAGQLRSERELRNVAAIDIGTNSTHLLVASVDPSLHTFSVDLAEKSTTRLGERDPDSGELTGPA
MERVFETLKRFKELAASHQVEQVVASATSAVREASNGRDFLQRIQDQLGLEVDLLSGAEEARLIYLGVLSGMPFGECPHL
LLDIGGGSTELILADGRDARALTSTRVGAVRLQRDFVKHEPIPPQRRSFLQTFIQGSLEPAVDKVCRRINPGESPVMVAT
SGTAMAIGALLASEDDRPPLRLHGYRFSRQRLDGLVEKLIAMTPEQRRIQTPINDRRSEIIVPGALILQTAMQMLAADEL
VLSERALREGLIVDWMLRHGLLEDRFSFQSSIRQRTVIHQVQRFAVNHRRAERVASHALSLYDHTHGVLHHDDGGGRDLL
WASAMLHACGQHINLSAYHKHSWYLIRHGELLGYSEAEHLMVAAIARYHRRSLPKKRHLEWQALATREHRRLVAEMALLL
RLAAAIDRRPEPVVAAIRVESADDDQVVFELVPEGLNQNLSLEQWSLKSCASVVKEASGVTMKVVVEE

Sequences:

>Translated_548_residues
MPFGVVDVEQEEARYASAGQLRSERELRNVAAIDIGTNSTHLLVASVDPSLHTFSVDLAEKSTTRLGERDPDSGELTGPA
MERVFETLKRFKELAASHQVEQVVASATSAVREASNGRDFLQRIQDQLGLEVDLLSGAEEARLIYLGVLSGMPFGECPHL
LLDIGGGSTELILADGRDARALTSTRVGAVRLQRDFVKHEPIPPQRRSFLQTFIQGSLEPAVDKVCRRINPGESPVMVAT
SGTAMAIGALLASEDDRPPLRLHGYRFSRQRLDGLVEKLIAMTPEQRRIQTPINDRRSEIIVPGALILQTAMQMLAADEL
VLSERALREGLIVDWMLRHGLLEDRFSFQSSIRQRTVIHQVQRFAVNHRRAERVASHALSLYDHTHGVLHHDDGGGRDLL
WASAMLHACGQHINLSAYHKHSWYLIRHGELLGYSEAEHLMVAAIARYHRRSLPKKRHLEWQALATREHRRLVAEMALLL
RLAAAIDRRPEPVVAAIRVESADDDQVVFELVPEGLNQNLSLEQWSLKSCASVVKEASGVTMKVVVEE
>Mature_547_residues
PFGVVDVEQEEARYASAGQLRSERELRNVAAIDIGTNSTHLLVASVDPSLHTFSVDLAEKSTTRLGERDPDSGELTGPAM
ERVFETLKRFKELAASHQVEQVVASATSAVREASNGRDFLQRIQDQLGLEVDLLSGAEEARLIYLGVLSGMPFGECPHLL
LDIGGGSTELILADGRDARALTSTRVGAVRLQRDFVKHEPIPPQRRSFLQTFIQGSLEPAVDKVCRRINPGESPVMVATS
GTAMAIGALLASEDDRPPLRLHGYRFSRQRLDGLVEKLIAMTPEQRRIQTPINDRRSEIIVPGALILQTAMQMLAADELV
LSERALREGLIVDWMLRHGLLEDRFSFQSSIRQRTVIHQVQRFAVNHRRAERVASHALSLYDHTHGVLHHDDGGGRDLLW
ASAMLHACGQHINLSAYHKHSWYLIRHGELLGYSEAEHLMVAAIARYHRRSLPKKRHLEWQALATREHRRLVAEMALLLR
LAAAIDRRPEPVVAAIRVESADDDQVVFELVPEGLNQNLSLEQWSLKSCASVVKEASGVTMKVVVEE

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=436, Percent_Identity=28.6697247706422, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI48994966, Length=427, Percent_Identity=28.5714285714286, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 61049; Mature: 60917

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFGVVDVEQEEARYASAGQLRSERELRNVAAIDIGTNSTHLLVASVDPSLHTFSVDLAE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEEECCCCCEEEEEEHHH
KSTTRLGERDPDSGELTGPAMERVFETLKRFKELAASHQVEQVVASATSAVREASNGRDF
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LQRIQDQLGLEVDLLSGAEEARLIYLGVLSGMPFGECPHLLLDIGGGSTELILADGRDAR
HHHHHHHHCCEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCH
ALTSTRVGAVRLQRDFVKHEPIPPQRRSFLQTFIQGSLEPAVDKVCRRINPGESPVMVAT
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEE
SGTAMAIGALLASEDDRPPLRLHGYRFSRQRLDGLVEKLIAMTPEQRRIQTPINDRRSEI
CCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEE
IVPGALILQTAMQMLAADELVLSERALREGLIVDWMLRHGLLEDRFSFQSSIRQRTVIHQ
ECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VQRFAVNHRRAERVASHALSLYDHTHGVLHHDDGGGRDLLWASAMLHACGQHINLSAYHK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
HSWYLIRHGELLGYSEAEHLMVAAIARYHRRSLPKKRHLEWQALATREHRRLVAEMALLL
CCEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHH
RLAAAIDRRPEPVVAAIRVESADDDQVVFELVPEGLNQNLSLEQWSLKSCASVVKEASGV
HHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
TMKVVVEE
EEEEEEEC
>Mature Secondary Structure 
PFGVVDVEQEEARYASAGQLRSERELRNVAAIDIGTNSTHLLVASVDPSLHTFSVDLAE
CCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEEECCCCCEEEEEEHHH
KSTTRLGERDPDSGELTGPAMERVFETLKRFKELAASHQVEQVVASATSAVREASNGRDF
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LQRIQDQLGLEVDLLSGAEEARLIYLGVLSGMPFGECPHLLLDIGGGSTELILADGRDAR
HHHHHHHHCCEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCH
ALTSTRVGAVRLQRDFVKHEPIPPQRRSFLQTFIQGSLEPAVDKVCRRINPGESPVMVAT
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEE
SGTAMAIGALLASEDDRPPLRLHGYRFSRQRLDGLVEKLIAMTPEQRRIQTPINDRRSEI
CCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEE
IVPGALILQTAMQMLAADELVLSERALREGLIVDWMLRHGLLEDRFSFQSSIRQRTVIHQ
ECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VQRFAVNHRRAERVASHALSLYDHTHGVLHHDDGGGRDLLWASAMLHACGQHINLSAYHK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
HSWYLIRHGELLGYSEAEHLMVAAIARYHRRSLPKKRHLEWQALATREHRRLVAEMALLL
CCEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHH
RLAAAIDRRPEPVVAAIRVESADDDQVVFELVPEGLNQNLSLEQWSLKSCASVVKEASGV
HHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
TMKVVVEE
EEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]