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The map label for this gene is lpxB

Identifier: 124022263

GI number: 124022263

Start: 536087

End: 537265

Strand: Direct

Name: lpxB

Synonym: P9303_05531

Alternate gene names: 124022263

Gene position: 536087-537265 (Clockwise)

Preceding gene: 124022262

Following gene: 124022264

Centisome position: 19.98

GC content: 56.32

Gene sequence:

>1179_bases
ATGGTGCGCCTGCTGATCAGCACTGGCGAGGTCTCTGGTGATTTGCAGGGAAGTCTCTTGATTCAAGCTCTTCAAAGGGA
GGTTGAACGGCGTTCCTTACCGCTTGAGTTGATGGCCCTTGGAGGTCCCCGCATGCAGGCTTCTGGTGCAGAACTGCTTG
CTGATACGGCTCCGATGGGTGCGATTGGACTTTGGGAGGCCCTGCCTCTGGTGCTCCCCACTTTGCGACTTCAGTCTCGG
GTGGATCACGTGCTCAAGCAGCGACCACCCGATGCCGTGGTGCTGATCGATTACATGGGGGCCAACGTGCGTTTGGGGCA
CAAGTTGCGGCGCTGGTTTCCCAGGGTGCCGATCATTTACTACATCGCTCCTCAGGAATGGGCTTGGCGTTTTGGCGATG
GCGGCACCACTCAGCTGCTGAGTTTCACCGACAGAATTTTGGCGATCTTTCCCGTTGAAGCTGAGTTCTATGCCCAGCGG
GGGGCCAAGGTGACGTGGGTCGGTCATCCATTACTCGATACGGTGAGTGTGCTGCCTGATCGTCAGCTGGCGCGTGAGCG
GCTTGGCTTGAAGTCTGGCCAAAGATTGTTGTTGCTTTTACCGGCTTCCCGGCAACAGGAACTTCGTTACTTGATGCCCA
CTCTCGCCAAGGCAGCAGCTTTGCTTCAGCAGCGTGACCCATCCCTTGAGGTGATTGTTCCTGCCGGATTAGCAAGTTTT
GAGACGTCTTTGCAGAAGGCTCTTGAGGCCGCGGCAGTTCGAGGGCGAGTCCTTTCGGCTCAGCAGGCCGATGAACTCAA
ACCAATGCTTTATGCGGCGGCTGATCTTGCCCTCGGCAAATCAGGCACCGTCAATATGGAGCTGGCCTTGCGTGGCGTTC
CCCAGGTGGTGGGCTACAAGGTGAGTCGGATCACAGCATTTGTGGCTCGACACTTTTTGCGCTTTCGGGTGGACCATATC
TCGCCGGTGAATCTGTTGCTGAAGGAACGGCTTGTGCCGGAATTACTACAGGATGAGTTCACTGCAGAAGCACTTGTGCA
GGCCGCTATCCCTTTATTGGAGGATCCTGCCCAGCGTCATGAGATGCTCGAGGGCTATTGGCGATTGCGGCAGACGCTTG
GCGTTCCAGGTGTTACCGATAGGGCAGCCAAGGAAATCCTTGATTTAACCAAGCCATGA

Upstream 100 bases:

>100_bases
AGCAGTTGATGCCAGCGGCTGCACACCTCTGTGCCTTCCTGGAGGCCTCGATTGAGAAGGGACGTCGCGGTCCTATGCCT
GCGACGTCTTTGAGTCGCTG

Downstream 100 bases:

>100_bases
AGACAACGTTTCGACCTTTGAGGAGATGGTGGATTGCCATCTTTCTCTGTGTTGCCTTACTTGGCTTGCCGCTTCAAGTT
TTGGCGTCAGTCGAGGAAGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMGAIGLWEALPLVLPTLRLQSR
VDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIYYIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYAQR
GAKVTWVGHPLLDTVSVLPDRQLARERLGLKSGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDPSLEVIVPAGLASF
ETSLQKALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMELALRGVPQVVGYKVSRITAFVARHFLRFRVDHI
SPVNLLLKERLVPELLQDEFTAEALVQAAIPLLEDPAQRHEMLEGYWRLRQTLGVPGVTDRAAKEILDLTKP

Sequences:

>Translated_392_residues
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMGAIGLWEALPLVLPTLRLQSR
VDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIYYIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYAQR
GAKVTWVGHPLLDTVSVLPDRQLARERLGLKSGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDPSLEVIVPAGLASF
ETSLQKALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMELALRGVPQVVGYKVSRITAFVARHFLRFRVDHI
SPVNLLLKERLVPELLQDEFTAEALVQAAIPLLEDPAQRHEMLEGYWRLRQTLGVPGVTDRAAKEILDLTKP
>Mature_392_residues
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMGAIGLWEALPLVLPTLRLQSR
VDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIYYIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYAQR
GAKVTWVGHPLLDTVSVLPDRQLARERLGLKSGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDPSLEVIVPAGLASF
ETSLQKALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMELALRGVPQVVGYKVSRITAFVARHFLRFRVDHI
SPVNLLLKERLVPELLQDEFTAEALVQAAIPLLEDPAQRHEMLEGYWRLRQTLGVPGVTDRAAKEILDLTKP

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=386, Percent_Identity=30.8290155440415, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_PROM3 (A2C745)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016570.1
- STRING:   A2C745
- GeneID:   4778596
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_05531
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 43486; Mature: 43486

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMG
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCC
AIGLWEALPLVLPTLRLQSRVDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHCCCCCEEE
YIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYAQRGAKVTWVGHPLLDTVSVLPD
EECCCCCCEEECCCCHHHHHHHHHHEEEEECCCHHHHHHCCCEEEEECCHHHHHHHHCCC
RQLARERLGLKSGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDPSLEVIVPAGLASF
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
ETSLQKALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMELALRGVPQVVGYK
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHH
VSRITAFVARHFLRFRVDHISPVNLLLKERLVPELLQDEFTAEALVQAAIPLLEDPAQRH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EMLEGYWRLRQTLGVPGVTDRAAKEILDLTKP
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MVRLLISTGEVSGDLQGSLLIQALQREVERRSLPLELMALGGPRMQASGAELLADTAPMG
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCC
AIGLWEALPLVLPTLRLQSRVDHVLKQRPPDAVVLIDYMGANVRLGHKLRRWFPRVPIIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHCCCCCEEE
YIAPQEWAWRFGDGGTTQLLSFTDRILAIFPVEAEFYAQRGAKVTWVGHPLLDTVSVLPD
EECCCCCCEEECCCCHHHHHHHHHHEEEEECCCHHHHHHCCCEEEEECCHHHHHHHHCCC
RQLARERLGLKSGQRLLLLLPASRQQELRYLMPTLAKAAALLQQRDPSLEVIVPAGLASF
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
ETSLQKALEAAAVRGRVLSAQQADELKPMLYAAADLALGKSGTVNMELALRGVPQVVGYK
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHH
VSRITAFVARHFLRFRVDHISPVNLLLKERLVPELLQDEFTAEALVQAAIPLLEDPAQRH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EMLEGYWRLRQTLGVPGVTDRAAKEILDLTKP
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA