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The map label for this gene is msrA2 [H]

Identifier: 124022264

GI number: 124022264

Start: 537262

End: 537933

Strand: Direct

Name: msrA2 [H]

Synonym: P9303_05541

Alternate gene names: 124022264

Gene position: 537262-537933 (Clockwise)

Preceding gene: 124022263

Following gene: 124022265

Centisome position: 20.03

GC content: 51.34

Gene sequence:

>672_bases
ATGAAGACAACGTTTCGACCTTTGAGGAGATGGTGGATTGCCATCTTTCTCTGTGTTGCCTTACTTGGCTTGCCGCTTCA
AGTTTTGGCGTCAGTCGAGGAAGCCGTTTTTGCCGGGGGCTGCTTCTGGTGTCTTGAGCATGATCTGGAGGGATTAACCG
GTGTGATTTCTGCTGAGAGTGGTTACACAGGTGGTGATTTGCCTCGCCCCACCTACAGCCAGGTGAGCTCTAAGACCACA
GGTCATCAAGAGGCCGTACGGGTGCGATTTGATGCTGCTCAAATCAGCTATGCAGAGCTACTACGCAGCTATTGGCGCAA
TGTTGACCCTCTTGATGGTGATGGCCAATTTTGTGATCAAGGTGACTCCTATCGACCTGTGATCTTCACCCGAGATGATC
AGCAGGACAGCGAGGCTCGTGAGAGTGCTGATGCTGCGGCTTTGGAGCTGGCCGAGCCCATGAGCAATCTGAAAGTTGAG
ATCAAACCTTTAAGCGAATTCTGGCTGGCTGAGGATTACCACCAGAATTACGCTGAGCTCAATAGCATCAAATACAACTT
CTATCGATACAGCTGTGGCCGCGACCGTCGGCTAGATCAGCTATGGGGTGACAAAGCACGAACCGGCTTGCCATGGCAGC
GCCCAGATCAAGCGAATCTAAGGAAAAAATAA

Upstream 100 bases:

>100_bases
GTCATGAGATGCTCGAGGGCTATTGGCGATTGCGGCAGACGCTTGGCGTTCCAGGTGTTACCGATAGGGCAGCCAAGGAA
ATCCTTGATTTAACCAAGCC

Downstream 100 bases:

>100_bases
AATCAGGATGACCTTTGAAATCGGGTAGTTCGCAGTGAAGATGCGGGTTTCCACCCATTCCTCCTGCTGAAAAAGCTGCT
TAACATCTACTGGAGATTTA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKTTFRPLRRWWIAIFLCVALLGLPLQVLASVEEAVFAGGCFWCLEHDLEGLTGVISAESGYTGGDLPRPTYSQVSSKTT
GHQEAVRVRFDAAQISYAELLRSYWRNVDPLDGDGQFCDQGDSYRPVIFTRDDQQDSEARESADAAALELAEPMSNLKVE
IKPLSEFWLAEDYHQNYAELNSIKYNFYRYSCGRDRRLDQLWGDKARTGLPWQRPDQANLRKK

Sequences:

>Translated_223_residues
MKTTFRPLRRWWIAIFLCVALLGLPLQVLASVEEAVFAGGCFWCLEHDLEGLTGVISAESGYTGGDLPRPTYSQVSSKTT
GHQEAVRVRFDAAQISYAELLRSYWRNVDPLDGDGQFCDQGDSYRPVIFTRDDQQDSEARESADAAALELAEPMSNLKVE
IKPLSEFWLAEDYHQNYAELNSIKYNFYRYSCGRDRRLDQLWGDKARTGLPWQRPDQANLRKK
>Mature_223_residues
MKTTFRPLRRWWIAIFLCVALLGLPLQVLASVEEAVFAGGCFWCLEHDLEGLTGVISAESGYTGGDLPRPTYSQVSSKTT
GHQEAVRVRFDAAQISYAELLRSYWRNVDPLDGDGQFCDQGDSYRPVIFTRDDQQDSEARESADAAALELAEPMSNLKVE
IKPLSEFWLAEDYHQNYAELNSIKYNFYRYSCGRDRRLDQLWGDKARTGLPWQRPDQANLRKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=152, Percent_Identity=38.1578947368421, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI208609995, Length=152, Percent_Identity=38.1578947368421, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI208609993, Length=120, Percent_Identity=34.1666666666667, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=43.421052631579, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=30.8724832214765, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25483; Mature: 25483

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTFRPLRRWWIAIFLCVALLGLPLQVLASVEEAVFAGGCFWCLEHDLEGLTGVISAES
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCC
GYTGGDLPRPTYSQVSSKTTGHQEAVRVRFDAAQISYAELLRSYWRNVDPLDGDGQFCDQ
CCCCCCCCCCCHHHHHCCCCCHHHHHEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GDSYRPVIFTRDDQQDSEARESADAAALELAEPMSNLKVEIKPLSEFWLAEDYHQNYAEL
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHH
NSIKYNFYRYSCGRDRRLDQLWGDKARTGLPWQRPDQANLRKK
HHEEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTTFRPLRRWWIAIFLCVALLGLPLQVLASVEEAVFAGGCFWCLEHDLEGLTGVISAES
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCC
GYTGGDLPRPTYSQVSSKTTGHQEAVRVRFDAAQISYAELLRSYWRNVDPLDGDGQFCDQ
CCCCCCCCCCCHHHHHCCCCCHHHHHEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GDSYRPVIFTRDDQQDSEARESADAAALELAEPMSNLKVEIKPLSEFWLAEDYHQNYAEL
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHH
NSIKYNFYRYSCGRDRRLDQLWGDKARTGLPWQRPDQANLRKK
HHEEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]