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The map label for this gene is lpxA [H]

Identifier: 124022262

GI number: 124022262

Start: 535236

End: 536087

Strand: Direct

Name: lpxA [H]

Synonym: P9303_05521

Alternate gene names: 124022262

Gene position: 535236-536087 (Clockwise)

Preceding gene: 124022261

Following gene: 124022263

Centisome position: 19.95

GC content: 56.22

Gene sequence:

>852_bases
ATGAGCGAGGTGGGCAAACTCTCAGCGATCACTGCCGAAAAAAAGGCTCAGGTTCACCCTGCGGCTGTGGTGGATCCTCG
TGCTGAGCTCGCTTCCGGTGTCATTGTTGGGCCGGGAGCAGTGATTGGACCTGACGTGAAGATTGGTCCTGATACCTGGA
TTGGTCCCCATGTGGTGCTCGATGGCCGTTTGACCCTTGGTGCCAATAACCGGGTTTTCCCTGGAGCCTGCCTTGGTCTT
GAGCCACAGGACCTCAAGTATCGCGGCGCACCCACAGAGGTGGTGATTGGCGATGCCAACACAATTAGGGAATACGTCAC
CATCAACCGGGCCACGGAGGAAGGTGAACAGACCAGGATCGGTGATCACAACTTGTTGATGGCCTATTGCCACCTTGGTC
ACAACTGTGAGCTGGGCAATGGGATTGTGATGTCGAATGGAATTCAAGTTGCTGGTCATGTCGTGGTCGAAGACCGGGCC
GTGATCGGCGGCTGCTTAGGAATTCACCAATTCGTTCACATTGGCAGTCTTGCCATGGTTGGAGGCATGACAAGGGTTGA
TCGCGATGTACCCCCGTACTGCCTCGCCGAAGGGCATCCAGGTCGATTGAGGGGTCTTAATCGCGTTGGCCTGCGGCGCA
GTGGTCTGAAGACTCAAGAGGGAGGAGAGCTTGGCCAGTTGCAGGAGATTTGGAATCTGCTGTTTCGATCTGACCATGTC
TTTGTTGAGGGGTTGCGGCTTGCTCGACAAGAGCAGTTGATGCCAGCGGCTGCACACCTCTGTGCCTTCCTGGAGGCCTC
GATTGAGAAGGGACGTCGCGGTCCTATGCCTGCGACGTCTTTGAGTCGCTGA

Upstream 100 bases:

>100_bases
TGAAGCGGCAGCGCTTTGGCAAAGTCAGGGGGGAAGCCAGGGTGGAGGGCCAGCTGGTTTGCTCTGGTGAGTTGATGTTT
TCCTTGGTGGACTGAGGATC

Downstream 100 bases:

>100_bases
TGGTGCGCCTGCTGATCAGCACTGGCGAGGTCTCTGGTGATTTGCAGGGAAGTCTCTTGATTCAAGCTCTTCAAAGGGAG
GTTGAACGGCGTTCCTTACC

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSEVGKLSAITAEKKAQVHPAAVVDPRAELASGVIVGPGAVIGPDVKIGPDTWIGPHVVLDGRLTLGANNRVFPGACLGL
EPQDLKYRGAPTEVVIGDANTIREYVTINRATEEGEQTRIGDHNLLMAYCHLGHNCELGNGIVMSNGIQVAGHVVVEDRA
VIGGCLGIHQFVHIGSLAMVGGMTRVDRDVPPYCLAEGHPGRLRGLNRVGLRRSGLKTQEGGELGQLQEIWNLLFRSDHV
FVEGLRLARQEQLMPAAAHLCAFLEASIEKGRRGPMPATSLSR

Sequences:

>Translated_283_residues
MSEVGKLSAITAEKKAQVHPAAVVDPRAELASGVIVGPGAVIGPDVKIGPDTWIGPHVVLDGRLTLGANNRVFPGACLGL
EPQDLKYRGAPTEVVIGDANTIREYVTINRATEEGEQTRIGDHNLLMAYCHLGHNCELGNGIVMSNGIQVAGHVVVEDRA
VIGGCLGIHQFVHIGSLAMVGGMTRVDRDVPPYCLAEGHPGRLRGLNRVGLRRSGLKTQEGGELGQLQEIWNLLFRSDHV
FVEGLRLARQEQLMPAAAHLCAFLEASIEKGRRGPMPATSLSR
>Mature_282_residues
SEVGKLSAITAEKKAQVHPAAVVDPRAELASGVIVGPGAVIGPDVKIGPDTWIGPHVVLDGRLTLGANNRVFPGACLGLE
PQDLKYRGAPTEVVIGDANTIREYVTINRATEEGEQTRIGDHNLLMAYCHLGHNCELGNGIVMSNGIQVAGHVVVEDRAV
IGGCLGIHQFVHIGSLAMVGGMTRVDRDVPPYCLAEGHPGRLRGLNRVGLRRSGLKTQEGGELGQLQEIWNLLFRSDHVF
VEGLRLARQEQLMPAAAHLCAFLEASIEKGRRGPMPATSLSR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=226, Percent_Identity=41.5929203539823, Blast_Score=180, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 30240; Mature: 30109

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVGKLSAITAEKKAQVHPAAVVDPRAELASGVIVGPGAVIGPDVKIGPDTWIGPHVVL
CCCCCCCCHHHHHHHCCCCCCEEECCHHHHHCCEEECCCCEECCCCEECCCCCCCCEEEE
DGRLTLGANNRVFPGACLGLEPQDLKYRGAPTEVVIGDANTIREYVTINRATEEGEQTRI
CCEEEECCCCCCCCCEEECCCCCCCEECCCCCEEEECCHHHHHHHHEEECCCCCCCCCCC
GDHNLLMAYCHLGHNCELGNGIVMSNGIQVAGHVVVEDRAVIGGCLGIHQFVHIGSLAMV
CCCCEEEEEECCCCCCCCCCCEEEECCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
GGMTRVDRDVPPYCLAEGHPGRLRGLNRVGLRRSGLKTQEGGELGQLQEIWNLLFRSDHV
CCCHHHCCCCCCCEECCCCCHHHCCCHHHCCHHCCCCCCCCCCHHHHHHHHHHHHCCCHH
FVEGLRLARQEQLMPAAAHLCAFLEASIEKGRRGPMPATSLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEVGKLSAITAEKKAQVHPAAVVDPRAELASGVIVGPGAVIGPDVKIGPDTWIGPHVVL
CCCCCCCHHHHHHHCCCCCCEEECCHHHHHCCEEECCCCEECCCCEECCCCCCCCEEEE
DGRLTLGANNRVFPGACLGLEPQDLKYRGAPTEVVIGDANTIREYVTINRATEEGEQTRI
CCEEEECCCCCCCCCEEECCCCCCCEECCCCCEEEECCHHHHHHHHEEECCCCCCCCCCC
GDHNLLMAYCHLGHNCELGNGIVMSNGIQVAGHVVVEDRAVIGGCLGIHQFVHIGSLAMV
CCCCEEEEEECCCCCCCCCCCEEEECCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
GGMTRVDRDVPPYCLAEGHPGRLRGLNRVGLRRSGLKTQEGGELGQLQEIWNLLFRSDHV
CCCHHHCCCCCCCEECCCCCHHHCCCHHHCCHHCCCCCCCCCCHHHHHHHHHHHHCCCHH
FVEGLRLARQEQLMPAAAHLCAFLEASIEKGRRGPMPATSLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]