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The map label for this gene is bioF [C]

Identifier: 124022169

GI number: 124022169

Start: 459471

End: 460613

Strand: Reverse

Name: bioF [C]

Synonym: P9303_04591

Alternate gene names: 124022169

Gene position: 460613-459471 (Counterclockwise)

Preceding gene: 124022171

Following gene: 124022168

Centisome position: 17.17

GC content: 58.97

Gene sequence:

>1143_bases
ATGCAAAGCCAGCCCACAGCACGTCGCCGCCAGCTGCGCACCTGGCGGCCAGGGCCAGGGCCAGCTGAGTTCAAACCAGT
GTCAGCTCAGGGGGAATCAAAACCTCTACTAGATCTGGCCAGCAACGATTACCTAGGCCTATGTCGGCATCCTGATCTGA
TCGAAGCCGCCAGAGCGGCCTTGCATTCAGAAGGTGTTGGAGCAGGTGGATCCAGGCTAGTAACTGGCAGCCGGCCAGTG
CATGTTGCACTGGAAGAAGCACTCGCCGACTGGTTAGGTCGCGAGCGGGTCTTACTTTTCCCAAGCGGGTTCCAAGCAAA
CCTGGCCGCAGTGATCGCACTGGCCAACCGCAATACCCCAGTACTGGCTGATCGCCTAGCTCACCATTCTCTATTGATGG
GTGTCAAAGCAAGTGGCGCCAGGCTGCAGCGTTATGCCCACAATGACCTGGCAGACCTTGAGCGGCGCCTCAAGCTCTGC
CGGCATCATCAACCGCATCAACCGCCGCTTGTACTCACCGAAAGCCTATTCAGCATGGAGGGCACCAGTCCACCGCTCTC
AACAATGGCCGAGCTCTGCGAAGTGCATGGTGCCAGGCTGCTCGTGGATGAAGCCCATGCCCTGGGTGTAATCGGTCCTC
AAGGGCGAGGTCTTTGCCATGGGCTCTCTGCATCAGTGTCAATCATCAGCGGCACCTTCGGCAAAGCATTCGGTAGCGGT
GGTGCCTTCCTGGCAGGTGATTGCGCCATGGGCGATCACCTTCTGCAAAACAGTGGCGCCTTTCGTTACACCACAGCACT
GGCACCGCCTTTAGCGGCGGCAGCTCTCACTGCCCTAAACCTGATTAAATCTCACCCTCAATGGGGCAAGCAACTGCAAG
AGCGTGCCGAGCAATGGCGTGGTCAATTGGCAGCTAGAGGATGGGCTCGCCCGCCTGGGTATGGCCCCATCCTCTCTCTG
CTGATCGGTTCCGACCAACAAGCTCTGAATCGCCAAAGTCAACTCGAGGAAGCCGGCCTACTTAGCGTGGCCATCCGTCC
TCCCACTGTTCCAGAAGGCACGGCGCGCCTTCGGCTTGTGCTGCGCAGGGGGCTACCCGATGAGACATTGGAACGGCTGA
TGAGCGCCCTTGAAACTGGATGA

Upstream 100 bases:

>100_bases
TTCTGGCAATCGTTGGCATTGGCACCAGCCAGCATGCCAACAAGGCAAAATCAAGCCAAAGAAGCCATCCTGAACTGCGC
AGGGCTTGCAGACTGGACCC

Downstream 100 bases:

>100_bases
AAGAGGTAATCGCCATGCACGGATGGTGTGGCGATAGCAACACCTGGCAGCTCTGGGCCCGCCATTTTCAAGCCCATGGC
TGGTTGTGGCAAAGCCAAGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MQSQPTARRRQLRTWRPGPGPAEFKPVSAQGESKPLLDLASNDYLGLCRHPDLIEAARAALHSEGVGAGGSRLVTGSRPV
HVALEEALADWLGRERVLLFPSGFQANLAAVIALANRNTPVLADRLAHHSLLMGVKASGARLQRYAHNDLADLERRLKLC
RHHQPHQPPLVLTESLFSMEGTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSASVSIISGTFGKAFGSG
GAFLAGDCAMGDHLLQNSGAFRYTTALAPPLAAAALTALNLIKSHPQWGKQLQERAEQWRGQLAARGWARPPGYGPILSL
LIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLVLRRGLPDETLERLMSALETG

Sequences:

>Translated_380_residues
MQSQPTARRRQLRTWRPGPGPAEFKPVSAQGESKPLLDLASNDYLGLCRHPDLIEAARAALHSEGVGAGGSRLVTGSRPV
HVALEEALADWLGRERVLLFPSGFQANLAAVIALANRNTPVLADRLAHHSLLMGVKASGARLQRYAHNDLADLERRLKLC
RHHQPHQPPLVLTESLFSMEGTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSASVSIISGTFGKAFGSG
GAFLAGDCAMGDHLLQNSGAFRYTTALAPPLAAAALTALNLIKSHPQWGKQLQERAEQWRGQLAARGWARPPGYGPILSL
LIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLVLRRGLPDETLERLMSALETG
>Mature_380_residues
MQSQPTARRRQLRTWRPGPGPAEFKPVSAQGESKPLLDLASNDYLGLCRHPDLIEAARAALHSEGVGAGGSRLVTGSRPV
HVALEEALADWLGRERVLLFPSGFQANLAAVIALANRNTPVLADRLAHHSLLMGVKASGARLQRYAHNDLADLERRLKLC
RHHQPHQPPLVLTESLFSMEGTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSASVSIISGTFGKAFGSG
GAFLAGDCAMGDHLLQNSGAFRYTTALAPPLAAAALTALNLIKSHPQWGKQLQERAEQWRGQLAARGWARPPGYGPILSL
LIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLVLRRGLPDETLERLMSALETG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=375, Percent_Identity=30.4, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=31.0144927536232, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI83977444, Length=338, Percent_Identity=34.3195266272189, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI83977442, Length=338, Percent_Identity=34.3195266272189, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI83977440, Length=338, Percent_Identity=34.3195266272189, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=29.4277929155313, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI4502025, Length=329, Percent_Identity=32.5227963525836, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI40316939, Length=329, Percent_Identity=32.5227963525836, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=27.9891304347826, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI5454084, Length=375, Percent_Identity=28.8, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=38.3522727272727, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1790046, Length=346, Percent_Identity=32.0809248554913, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71994529, Length=357, Percent_Identity=30.2521008403361, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=28.7671232876712, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=370, Percent_Identity=26.4864864864865, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17560914, Length=367, Percent_Identity=26.158038147139, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=282, Percent_Identity=26.9503546099291, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=282, Percent_Identity=26.9503546099291, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320438, Length=383, Percent_Identity=28.4595300261097, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320267, Length=364, Percent_Identity=27.1978021978022, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=326, Percent_Identity=25.7668711656442, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=29.0502793296089, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=33.5211267605634, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17136286, Length=374, Percent_Identity=29.9465240641711, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24653280, Length=377, Percent_Identity=24.1379310344828, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24653276, Length=377, Percent_Identity=24.1379310344828, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24653278, Length=377, Percent_Identity=24.1379310344828, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 40674; Mature: 40674

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSQPTARRRQLRTWRPGPGPAEFKPVSAQGESKPLLDLASNDYLGLCRHPDLIEAARAA
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEECCCCHHHHHHHHH
LHSEGVGAGGSRLVTGSRPVHVALEEALADWLGRERVLLFPSGFQANLAAVIALANRNTP
HHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCCCC
VLADRLAHHSLLMGVKASGARLQRYAHNDLADLERRLKLCRHHQPHQPPLVLTESLFSME
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
GTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSASVSIISGTFGKAFGSG
CCCCCHHHHHHHHHHCCCEEEEECHHHCEEECCCCCCHHHCCCHHHHHHHCCHHHHHCCC
GAFLAGDCAMGDHLLQNSGAFRYTTALAPPLAAAALTALNLIKSHPQWGKQLQERAEQWR
CCEEECCHHHHHHHHHCCCCEEEEHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GQLAARGWARPPGYGPILSLLIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLV
HHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHH
LRRGLPDETLERLMSALETG
HHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSQPTARRRQLRTWRPGPGPAEFKPVSAQGESKPLLDLASNDYLGLCRHPDLIEAARAA
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEECCCCHHHHHHHHH
LHSEGVGAGGSRLVTGSRPVHVALEEALADWLGRERVLLFPSGFQANLAAVIALANRNTP
HHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCCCC
VLADRLAHHSLLMGVKASGARLQRYAHNDLADLERRLKLCRHHQPHQPPLVLTESLFSME
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
GTSPPLSTMAELCEVHGARLLVDEAHALGVIGPQGRGLCHGLSASVSIISGTFGKAFGSG
CCCCCHHHHHHHHHHCCCEEEEECHHHCEEECCCCCCHHHCCCHHHHHHHCCHHHHHCCC
GAFLAGDCAMGDHLLQNSGAFRYTTALAPPLAAAALTALNLIKSHPQWGKQLQERAEQWR
CCEEECCHHHHHHHHHCCCCEEEEHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GQLAARGWARPPGYGPILSLLIGSDQQALNRQSQLEEAGLLSVAIRPPTVPEGTARLRLV
HHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHH
LRRGLPDETLERLMSALETG
HHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA