Click here to switch to the map view.

The map label for this gene is argH

Identifier: 124021727

GI number: 124021727

Start: 15728

End: 17140

Strand: Direct

Name: argH

Synonym: P9303_00121

Alternate gene names: 124021727

Gene position: 15728-17140 (Clockwise)

Preceding gene: 124021726

Following gene: 124021728

Centisome position: 0.59

GC content: 50.81

Gene sequence:

>1413_bases
ATGGCAGGTGGAGTAACCGGTGGTTCTGCAGAAGGCTGGAGCAAAAGGTTTGAAGAGGGATTGCATCCGGTTATTGAGCG
GTTCAATGCTTCCATCAGCTTTGACATCACTCTGCTCCAAGAAGATTTAGATGGGTCTATCGCTCATGCACGCATGCTTG
GCGAATGTGGAGTGATCAGTCTTGAAGAGGCCGCTCAGCTTGAGGGCGGCCTTGAGAAAATCCGCTCAGAGGCAGCGGCA
GGAGAGTTTCAGCCAGGACTTGTTGATGAAGATGTTCATTTCGCTGTTGAACGGCGCCTGATCGCTTTATTAGGGCCTGT
CGGCAAGAAACTTCATACCGGCCGAAGTCGCAATGATCAGGTAGGCACGGATCTGCGCTTGTGGTTACGGCGTCGCTTGG
ATGATTTGGATTGTGAACTGGAGCGGTTTCAGAATGCTCTTTTGACACAGGCAGAATCCCATCGTCAAACTTTGATTCCC
GGCTACACCCACTTACAGCGTGCCCAGCCGCTTTGCTTGGCCCATCATCTTTTGGCTTATATCGAGATGATCCAAAGGGA
TAGAGATCGGCTTAAAGATGTTCGCGGACGAGTCAATATTTCGCCGCTTGGTGCGGCTGCCCTTGCAGGAACATCAGTGC
CTATTGATCGCCAAAATACAGCAGCAGCACTTGGCTTTGAGTGTATTTACGCGAATAGTCTGGATGCGGTAAGTGATCGC
GATTTTGCTGTTGAGTACACAGCGGCGGCTTCGTTGGTCATGGTCCATCTCAGTCGCCTGGCGGAGGAGGTGATTTTCTG
GGCGTCTGAGGAATTTGCATTTGTGCGTCTCAGCGACCGTTGTGCCACTGGCAGCAGCTTGATGCCTCAGAAGAAGAATC
CTGATGTGCCTGAATTGGTACGAGGCAAATGTGGTCGTGTGTTTGGTCACCTTCAGGGTCTCCTGACCATGATTAAGGGA
TTGCCATTGGCTTACAACAAGGATTTTCAGGAGGATAAGGAAGCTCTCTTTGACACCGTTCGCACTACTAAAGATTGTGT
GGAAGCCATGTCGATTTTGATGGAGCAAGGGTTGGAGTTTTGTTCGGAACGCTTGGCAGCTGCCGTTGAATCCGATTTTT
CCAATGCCACTGATGTGGCTGACTACCTGGTTGCTAAAGGAGTGCCCTTTCGGGAGGCCTACCAATTGGTGGGTGCGGTT
GTGAAGCGTTGTTTAGACGAAGGGATTTTGCTTTGTGATCTAAGCCTTGAACAATGGCAGGAATTTCACTCCGCTATTGC
TGAGGATTTGCATGAAGCATTGGCTCCAAAGCGGGTTGTGGCTGTGCGGATTAGTGAAGGTGGCACTGGTTTTGATCGAG
TTGAGGAGCAATTGCGTCACTGGCGTAGCCGCCTTGATTCCGGAGTGTCATGA

Upstream 100 bases:

>100_bases
AAGATGATGCCTCAATGGTGGTTTTGAAAGTGCCAGAGGAGGTAACGCTGCCTTCTGTGTCCCTGGCCTGACAAGCTGTT
GACTCGCTGCTCATGAAGGG

Downstream 100 bases:

>100_bases
TCGAAATGCCTCGGCGGGTCTACGCTGATAGCGCCAAAGGTGGATTGATTCATTCCCGAATCATGAACTAATGGCTATAC
CTGGCCAATTGGTCCACTAC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MAGGVTGGSAEGWSKRFEEGLHPVIERFNASISFDITLLQEDLDGSIAHARMLGECGVISLEEAAQLEGGLEKIRSEAAA
GEFQPGLVDEDVHFAVERRLIALLGPVGKKLHTGRSRNDQVGTDLRLWLRRRLDDLDCELERFQNALLTQAESHRQTLIP
GYTHLQRAQPLCLAHHLLAYIEMIQRDRDRLKDVRGRVNISPLGAAALAGTSVPIDRQNTAAALGFECIYANSLDAVSDR
DFAVEYTAAASLVMVHLSRLAEEVIFWASEEFAFVRLSDRCATGSSLMPQKKNPDVPELVRGKCGRVFGHLQGLLTMIKG
LPLAYNKDFQEDKEALFDTVRTTKDCVEAMSILMEQGLEFCSERLAAAVESDFSNATDVADYLVAKGVPFREAYQLVGAV
VKRCLDEGILLCDLSLEQWQEFHSAIAEDLHEALAPKRVVAVRISEGGTGFDRVEEQLRHWRSRLDSGVS

Sequences:

>Translated_470_residues
MAGGVTGGSAEGWSKRFEEGLHPVIERFNASISFDITLLQEDLDGSIAHARMLGECGVISLEEAAQLEGGLEKIRSEAAA
GEFQPGLVDEDVHFAVERRLIALLGPVGKKLHTGRSRNDQVGTDLRLWLRRRLDDLDCELERFQNALLTQAESHRQTLIP
GYTHLQRAQPLCLAHHLLAYIEMIQRDRDRLKDVRGRVNISPLGAAALAGTSVPIDRQNTAAALGFECIYANSLDAVSDR
DFAVEYTAAASLVMVHLSRLAEEVIFWASEEFAFVRLSDRCATGSSLMPQKKNPDVPELVRGKCGRVFGHLQGLLTMIKG
LPLAYNKDFQEDKEALFDTVRTTKDCVEAMSILMEQGLEFCSERLAAAVESDFSNATDVADYLVAKGVPFREAYQLVGAV
VKRCLDEGILLCDLSLEQWQEFHSAIAEDLHEALAPKRVVAVRISEGGTGFDRVEEQLRHWRSRLDSGVS
>Mature_469_residues
AGGVTGGSAEGWSKRFEEGLHPVIERFNASISFDITLLQEDLDGSIAHARMLGECGVISLEEAAQLEGGLEKIRSEAAAG
EFQPGLVDEDVHFAVERRLIALLGPVGKKLHTGRSRNDQVGTDLRLWLRRRLDDLDCELERFQNALLTQAESHRQTLIPG
YTHLQRAQPLCLAHHLLAYIEMIQRDRDRLKDVRGRVNISPLGAAALAGTSVPIDRQNTAAALGFECIYANSLDAVSDRD
FAVEYTAAASLVMVHLSRLAEEVIFWASEEFAFVRLSDRCATGSSLMPQKKNPDVPELVRGKCGRVFGHLQGLLTMIKGL
PLAYNKDFQEDKEALFDTVRTTKDCVEAMSILMEQGLEFCSERLAAAVESDFSNATDVADYLVAKGVPFREAYQLVGAVV
KRCLDEGILLCDLSLEQWQEFHSAIAEDLHEALAPKRVVAVRISEGGTGFDRVEEQLRHWRSRLDSGVS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=43.7908496732026, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=43.7908496732026, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=41.1764705882353, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=41.3943355119826, Blast_Score=331, Evalue=8e-91,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=47.136563876652, Blast_Score=405, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=469, Percent_Identity=43.2835820895522, Blast_Score=346, Evalue=4e-96,
Organism=Drosophila melanogaster, GI221473854, Length=449, Percent_Identity=41.6481069042316, Blast_Score=334, Evalue=8e-92,
Organism=Drosophila melanogaster, GI78706858, Length=449, Percent_Identity=41.6481069042316, Blast_Score=334, Evalue=8e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_PROM3 (A2C5K9)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016034.1
- ProteinModelPortal:   A2C5K9
- SMR:   A2C5K9
- STRING:   A2C5K9
- GeneID:   4776025
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_00121
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51975; Mature: 51843

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGVTGGSAEGWSKRFEEGLHPVIERFNASISFDITLLQEDLDGSIAHARMLGECGVIS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCHHHHHHHHHCCCCEE
LEEAAQLEGGLEKIRSEAAAGEFQPGLVDEDVHFAVERRLIALLGPVGKKLHTGRSRNDQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VGTDLRLWLRRRLDDLDCELERFQNALLTQAESHRQTLIPGYTHLQRAQPLCLAHHLLAY
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHH
IEMIQRDRDRLKDVRGRVNISPLGAAALAGTSVPIDRQNTAAALGFECIYANSLDAVSDR
HHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCC
DFAVEYTAAASLVMVHLSRLAEEVIFWASEEFAFVRLSDRCATGSSLMPQKKNPDVPELV
CCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHH
RGKCGRVFGHLQGLLTMIKGLPLAYNKDFQEDKEALFDTVRTTKDCVEAMSILMEQGLEF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSERLAAAVESDFSNATDVADYLVAKGVPFREAYQLVGAVVKRCLDEGILLCDLSLEQWQ
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHH
EFHSAIAEDLHEALAPKRVVAVRISEGGTGFDRVEEQLRHWRSRLDSGVS
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AGGVTGGSAEGWSKRFEEGLHPVIERFNASISFDITLLQEDLDGSIAHARMLGECGVIS
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCHHHHHHHHHCCCCEE
LEEAAQLEGGLEKIRSEAAAGEFQPGLVDEDVHFAVERRLIALLGPVGKKLHTGRSRNDQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VGTDLRLWLRRRLDDLDCELERFQNALLTQAESHRQTLIPGYTHLQRAQPLCLAHHLLAY
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHH
IEMIQRDRDRLKDVRGRVNISPLGAAALAGTSVPIDRQNTAAALGFECIYANSLDAVSDR
HHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCC
DFAVEYTAAASLVMVHLSRLAEEVIFWASEEFAFVRLSDRCATGSSLMPQKKNPDVPELV
CCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHH
RGKCGRVFGHLQGLLTMIKGLPLAYNKDFQEDKEALFDTVRTTKDCVEAMSILMEQGLEF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSERLAAAVESDFSNATDVADYLVAKGVPFREAYQLVGAVVKRCLDEGILLCDLSLEQWQ
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHH
EFHSAIAEDLHEALAPKRVVAVRISEGGTGFDRVEEQLRHWRSRLDSGVS
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA