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The map label for this gene is hisB [H]

Identifier: 123965549

GI number: 123965549

Start: 290512

End: 291117

Strand: Reverse

Name: hisB [H]

Synonym: P9515_03141

Alternate gene names: 123965549

Gene position: 291117-290512 (Counterclockwise)

Preceding gene: 123965550

Following gene: 123965548

Centisome position: 17.08

GC content: 33.5

Gene sequence:

>606_bases
ATGTCATCCTCAAGACAAGCTGAAATTAAAAGAAAAACAAATGAAACAGATATTAGTATTTTTATTAATATAGATGGCAA
CGGAATTTCAGAAATTGATACAGGGATACCCTTCTTAGATCATATGCTTCATCAAATATCAAGTCACGGATTATTTGATT
TAAAAATAAGAGCTATAGGAGATACACACATTGATGATCATCATACAAATGAGGATGTCGGAATTGCCCTTGGTAAAGCA
TTTACCAAAGCCCTTGGAGAAAGAAAGGGGATAAACAGATTTGGGCATTTTTTTGCACCTTTAGATGAGGCTTTAGTTCA
AGTGACCTTAGATTGTTCAGGAAGGCCTCATTTATCTTATGGTCTCAAATTGAAAGCACCAAGAATAGGAAATTATGATA
CTGAATTAGTAAGAGAATTTTTTATAGCTTTTGTTAACAGTAGTGGAATAACCCTTCATATCAACCAAATAGAAGGGAGA
AATTCTCATCATATAGTTGAGGCATGTTTTAAAGCCTTTTCAAGATCAATGAGAATGGCTACTGAAATAGATTTAAGGAG
ATCCGGAACTATCCCTAGTAGTAAAGGAATGCTAGAAATTGATTAG

Upstream 100 bases:

>100_bases
TCTTTTGAGTGATCTTGCAAGTGGTATATCAGGCCAAACTATTTATGTTGATGCAGGTTATTGCATTAATGGAATGTAAA
TTAAAATTTTAAAAACTAAA

Downstream 100 bases:

>100_bases
CTATACAATTTAAGTATTTTTTTTAATAAGCCACAATTTTATAGATTTTTGGCGAAAATAAATAAAAATAAAACTTTAAA
GTGACTTATATTCAAGACAA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSSSRQAEIKRKTNETDISIFINIDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIGDTHIDDHHTNEDVGIALGKA
FTKALGERKGINRFGHFFAPLDEALVQVTLDCSGRPHLSYGLKLKAPRIGNYDTELVREFFIAFVNSSGITLHINQIEGR
NSHHIVEACFKAFSRSMRMATEIDLRRSGTIPSSKGMLEID

Sequences:

>Translated_201_residues
MSSSRQAEIKRKTNETDISIFINIDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIGDTHIDDHHTNEDVGIALGKA
FTKALGERKGINRFGHFFAPLDEALVQVTLDCSGRPHLSYGLKLKAPRIGNYDTELVREFFIAFVNSSGITLHINQIEGR
NSHHIVEACFKAFSRSMRMATEIDLRRSGTIPSSKGMLEID
>Mature_200_residues
SSSRQAEIKRKTNETDISIFINIDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIGDTHIDDHHTNEDVGIALGKAF
TKALGERKGINRFGHFFAPLDEALVQVTLDCSGRPHLSYGLKLKAPRIGNYDTELVREFFIAFVNSSGITLHINQIEGRN
SHHIVEACFKAFSRSMRMATEIDLRRSGTIPSSKGMLEID

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=46.9072164948454, Blast_Score=182, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=39.5454545454545, Blast_Score=166, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22403; Mature: 22272

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSRQAEIKRKTNETDISIFINIDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIG
CCCCCCHHHHHCCCCCEEEEEEEECCCCCCHHHCCCHHHHHHHHHHHCCCEEEEEEEEEC
DTHIDDHHTNEDVGIALGKAFTKALGERKGINRFGHFFAPLDEALVQVTLDCSGRPHLSY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHEEEEECCCCCCCCEE
GLKLKAPRIGNYDTELVREFFIAFVNSSGITLHINQIEGRNSHHIVEACFKAFSRSMRMA
CEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TEIDLRRSGTIPSSKGMLEID
HHHHHHCCCCCCCCCCCEEEC
>Mature Secondary Structure 
SSSRQAEIKRKTNETDISIFINIDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIG
CCCCCHHHHHCCCCCEEEEEEEECCCCCCHHHCCCHHHHHHHHHHHCCCEEEEEEEEEC
DTHIDDHHTNEDVGIALGKAFTKALGERKGINRFGHFFAPLDEALVQVTLDCSGRPHLSY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHEEEEECCCCCCCCEE
GLKLKAPRIGNYDTELVREFFIAFVNSSGITLHINQIEGRNSHHIVEACFKAFSRSMRMA
CEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TEIDLRRSGTIPSSKGMLEID
HHHHHHCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA