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The map label for this gene is glyA [H]

Identifier: 123965526

GI number: 123965526

Start: 267329

End: 268600

Strand: Reverse

Name: glyA [H]

Synonym: P9515_02911

Alternate gene names: 123965526

Gene position: 268600-267329 (Counterclockwise)

Preceding gene: 123965529

Following gene: 123965525

Centisome position: 15.76

GC content: 34.43

Gene sequence:

>1272_bases
ATGAATATTCTTCAAAATCTCAAAAAAAGTGATCCAATCATATCAAACTTAATTAATTCCGAAAAAAATAGACAAGAAAC
TCATCTTGAATTAATAGCTAGTGAGAATTTCGCATCAATGGCCGTAATGCAAGCTCAGGGATCAGTCTTAACAAATAAAT
ACGCTGAAGGTCTTCCTCAAAAAAGATATTACGGTGGTTGTGAATTTGTTGATGAAATCGAAGAACTAGCAATCGAGAGA
GCCAAGCAACTTTTTGATGCAGACTGGGCGAATGTTCAACCCCATAGTGGAGCACAAGCAAATGCAGCTGTGTTTTTAAG
TTTACTTAATCCAGGAGACACAATTTTAGGAATGGATTTATCTCATGGTGGACATTTAACCCACGGATCTCCTGTGAATA
TGAGTGGAAAGTGGTTCAATGCTGTGCACTATGGAGTTGATAAAGAAACTAATAAATTAAATTTTAATGTAATAAGAGAT
ATTGCTTTAGCTACAAAACCGAAACTCATTATCTGTGGATATTCTGCTTATCCAAGAACAATTGATTTCAAATCTTTCAG
AAGTATTGCTGATGAAGTTGGAGCTTTTTTAATGGCTGACATCGCTCATATTGCAGGACTAGTAGCTAGTAAACTTCATC
CGAATCCAATTCCATATTGCGATGTGGTAACTACTACAACTCATAAGACCTTGAGAGGTCCAAGAGGAGGATTGATTTTA
TGTAAAGATAAAGAATTTGGGAAAAAGTTTGATAAATCTGTTTTCCCAGGAACTCAAGGTGGGCCTTTAGAACATATTAT
CGCAGCTAAGGCAGTTGCCTTTGGAGAAGCTTTACAGCCCAACTTTGTTAATTACTCAAAACAGGTTATCAAAAATGCAA
AAGTTCTTTCTTCAACCTTAATCAACAGAGGAATAGATATTGTTAGTGGAGGTACGGATAATCATATTGTTTTGCTTGAC
TTAAGAAGTATTAATATGACAGGAAAAGTTGCTGATTTACTTGTAAGTGAAGTAAATATTACAGCAAATAAAAATACTGT
TCCGTTTGATCCTGAATCTCCTTTTGTCACAAGTGGGTTGAGATTAGGAACTGCAGCATTAACTACTCGAGGTTTTAATG
ATGAAGCTTTTATTGAAGTTGGTGAAATTATTGCTGATAGATTACTAAATCCAGATGATTTATTAATTGAAAAAGAATGT
AAGGAAAGGGTATTAAGTTTATGTAATAGTTTTCCTCTTTATGAAGCCAAACTTGAATCATCGATCAAATGA

Upstream 100 bases:

>100_bases
GAGTTCGAATCTCTCCAGGCGCGTAAAAAATTATGAAATATTTTTTTTATATTTTGTTTTAAAAAATCGTCTATATTTAA
TCTATAGTTTCCCTGTTTGA

Downstream 100 bases:

>100_bases
ACCTAATTGTAAAGGGGTTGAAATTCTTTCAATAGGAACTGAATTACTTTTAGGAAATATAGTCAACACTAATGCTCAGT
GGATTTCTGAGGAACTATCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNILQNLKKSDPIISNLINSEKNRQETHLELIASENFASMAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIER
AKQLFDADWANVQPHSGAQANAAVFLSLLNPGDTILGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVDKETNKLNFNVIRD
IALATKPKLIICGYSAYPRTIDFKSFRSIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CKDKEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPNFVNYSKQVIKNAKVLSSTLINRGIDIVSGGTDNHIVLLD
LRSINMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNDEAFIEVGEIIADRLLNPDDLLIEKEC
KERVLSLCNSFPLYEAKLESSIK

Sequences:

>Translated_423_residues
MNILQNLKKSDPIISNLINSEKNRQETHLELIASENFASMAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIER
AKQLFDADWANVQPHSGAQANAAVFLSLLNPGDTILGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVDKETNKLNFNVIRD
IALATKPKLIICGYSAYPRTIDFKSFRSIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CKDKEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPNFVNYSKQVIKNAKVLSSTLINRGIDIVSGGTDNHIVLLD
LRSINMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNDEAFIEVGEIIADRLLNPDDLLIEKEC
KERVLSLCNSFPLYEAKLESSIK
>Mature_423_residues
MNILQNLKKSDPIISNLINSEKNRQETHLELIASENFASMAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIER
AKQLFDADWANVQPHSGAQANAAVFLSLLNPGDTILGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVDKETNKLNFNVIRD
IALATKPKLIICGYSAYPRTIDFKSFRSIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CKDKEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPNFVNYSKQVIKNAKVLSSTLINRGIDIVSGGTDNHIVLLD
LRSINMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNDEAFIEVGEIIADRLLNPDDLLIEKEC
KERVLSLCNSFPLYEAKLESSIK

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=403, Percent_Identity=47.6426799007444, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI261862350, Length=403, Percent_Identity=47.6426799007444, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI261862348, Length=403, Percent_Identity=47.6426799007444, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI19923315, Length=403, Percent_Identity=47.6426799007444, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI261862346, Length=398, Percent_Identity=48.4924623115578, Blast_Score=344, Evalue=8e-95,
Organism=Homo sapiens, GI22547186, Length=405, Percent_Identity=46.4197530864198, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI22547189, Length=391, Percent_Identity=45.0127877237852, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=55.9610705596107, Blast_Score=457, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI25144732, Length=404, Percent_Identity=44.8019801980198, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI25144729, Length=404, Percent_Identity=44.8019801980198, Blast_Score=345, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=43.142144638404, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323087, Length=405, Percent_Identity=41.2345679012346, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=46.2121212121212, Blast_Score=356, Evalue=1e-98,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=46.2121212121212, Blast_Score=355, Evalue=2e-98,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46196; Mature: 46196

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILQNLKKSDPIISNLINSEKNRQETHLELIASENFASMAVMQAQGSVLTNKYAEGLPQ
CCHHHHHHHCCHHHHHHHCCCCCCHHHHHHEEECCCHHHHHHHHHCCCHHHHHHHHCCCC
KRYYGGCEFVDEIEELAIERAKQLFDADWANVQPHSGAQANAAVFLSLLNPGDTILGMDL
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
SHGGHLTHGSPVNMSGKWFNAVHYGVDKETNKLNFNVIRDIALATKPKLIICGYSAYPRT
CCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCEEHHHHHHHHHHCCCCEEEECCCCCCCC
IDFKSFRSIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHCCCCCCEEE
CKDKEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPNFVNYSKQVIKNAKVLSSTL
ECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
INRGIDIVSGGTDNHIVLLDLRSINMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGL
HHCCCEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFNDEAFIEVGEIIADRLLNPDDLLIEKECKERVLSLCNSFPLYEAKLES
HHCHHHHEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SIK
CCC
>Mature Secondary Structure
MNILQNLKKSDPIISNLINSEKNRQETHLELIASENFASMAVMQAQGSVLTNKYAEGLPQ
CCHHHHHHHCCHHHHHHHCCCCCCHHHHHHEEECCCHHHHHHHHHCCCHHHHHHHHCCCC
KRYYGGCEFVDEIEELAIERAKQLFDADWANVQPHSGAQANAAVFLSLLNPGDTILGMDL
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
SHGGHLTHGSPVNMSGKWFNAVHYGVDKETNKLNFNVIRDIALATKPKLIICGYSAYPRT
CCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCEEHHHHHHHHHHCCCCEEEECCCCCCCC
IDFKSFRSIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHCCCCCCEEE
CKDKEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPNFVNYSKQVIKNAKVLSSTL
ECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
INRGIDIVSGGTDNHIVLLDLRSINMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGL
HHCCCEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFNDEAFIEVGEIIADRLLNPDDLLIEKECKERVLSLCNSFPLYEAKLES
HHCHHHHEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SIK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA