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The map label for this gene is pepB

Identifier: 121638094

GI number: 121638094

Start: 2456982

End: 2458529

Strand: Direct

Name: pepB

Synonym: BCG_2229

Alternate gene names: 121638094

Gene position: 2456982-2458529 (Clockwise)

Preceding gene: 121638093

Following gene: 121638096

Centisome position: 56.17

GC content: 67.44

Gene sequence:

>1548_bases
GTGACCACCGAACCGGGTTACCTATCCCCCTCCGTCGCCGTCGCGACCTCGATGCCGAAACGTGGTGTCGGCGCTGCGGT
GTTGATCGTGCCGGTCGTCTCGACCGGCGAAGAGGATCGGCCCGGCGCGGTCGTTGCCTCGGCCGAGCCCTTCCTGCGCG
CCGACACGGTTGCCGAAATCGAGGCGGGCCTGCGAGCGCTGGACGCCACCGGCGCCAGTGACCAGGTGCACCGGCTGGCG
GTGCCGTCGTTGCCGGTGGGCAGCGTCCTGACGGTCGGCCTGGGCAAACCGCGGCGCGAATGGCCGGCCGATACCATCCG
CTGCGCCGCCGGCGTGGCCGCGCGTGCGCTCAACAGTTCGGAGGCAGTGATCACCACGCTAGCCGAATTACCTGGCGACG
GCATCTGCTCGGCCACCGTCGAGGGGCTGATCCTGGGCAGCTACCGATTCAGCGCCTTCCGCAGCGACAAGACCGCGCCC
AAAGACGCCGGACTCCGCAAAATCACCGTGCTCTGCTGTGCAAAGGACGCCAAGAAGCGCGCGTTGCACGGTGCGGCCGT
CGCGACCGCGGTGGCCACCGCCCGGGACTTGGTCAACACTCCCCCAAGCCACCTGTTTCCCGCCGAGTTGGCTAAGCGCG
CAAAGACTTTGAGCGAATCCGTCGGCCTCGACGTGGAAGTTATCGACGAAAAGGCGCTGAAGAAGGCCGGCTATGGCGGG
GTGATTGGTGTCGGCCAGGGCTCGTCGCGGCCGCCGCGACTGGTGCGGTTGATTCATCGGGGATCGCGGCTGGCCAAGAA
CCCCCAAAAGGCCAAGAAGGTGGCCTTGGTTGGCAAGGGGATCACCTTCGATACCGGCGGCATCTCGATCAAGCCGGCAG
CGTCGATGCACCACATGACCTCGGACATGGGCGGAGCGGCCGCGGTGATCGCCACTGTCACGCTGGCTGCCCGGCTGCGA
CTGCCGATTGACGTGATCGCCACGGTGCCGATGGCCGAGAACATGCCGTCGGCGACGGCGCAGCGCCCGGGCGACGTGCT
GACCCAATACGGTGGGACCACCGTCGAGGTGCTCAACACCGACGCGGAGGGCCGGTTGATCCTGGCCGACGCCATCGTCC
GGGCATGTGAGGACAAGCCGGACTATCTGATCGAGACATCCACGTTGACCGGTGCGCAAACGGTGGCGCTGGGGACGCGC
ATACCGGGTGTGATGGGCAGCGACGAGTTCCGCGACCGGGTCGCCGCGATCTCGCAGCGGGTGGGCGAGAACGGCTGGCC
GATGCCGCTGCCCGATGACCTCAAGGATGACTTGAAATCCACGGTGGCCGACCTGGCCAATGTGAGTGGCCAGCGTTTCG
CAGGCATGCTGGTGGCCGGGGTTTTCCTGCGTGAGTTCGTCGCCGAATCGGTGGATTGGGCGCACATCGACGTGGCCGGC
CCGGCCTACAACACCGGCAGCGCCTGGGGTTACACGCCCAAGGGCGCCACCGGTGTGCCCACCCGCACCATGTTCGCGGT
GCTCGAGGACATCGCGAAGAACGGGTAG

Upstream 100 bases:

>100_bases
GGTTTGACGCCCCGGTGATGGCCTTCGAACTGCACGACAACCCTCGTGCGAGGGATGCTGACACGCCAAGCCCCGCCGCC
AGTGATTAGGGTGGTTGCCC

Downstream 100 bases:

>100_bases
GCGGCCGCCCGGACCCAAAGCACTTCACGAGTAGCGGTTAGATCACCCGCAGCCGCGCGGTACTGCGCAGCGCCTGCGGC
AGCACCCGGGAGATGCCGTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEIEAGLRALDATGASDQVHRLA
VPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAP
KDAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAELAKRAKTLSESVGLDVEVIDEKALKKAGYGG
VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLR
LPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTR
IPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG
PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG

Sequences:

>Translated_515_residues
MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEIEAGLRALDATGASDQVHRLA
VPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAP
KDAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAELAKRAKTLSESVGLDVEVIDEKALKKAGYGG
VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLR
LPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTR
IPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG
PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG
>Mature_514_residues
TTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEIEAGLRALDATGASDQVHRLAV
PSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPK
DAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAELAKRAKTLSESVGLDVEVIDEKALKKAGYGGV
IGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLRL
PIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRI
PGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAGP
AYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=433, Percent_Identity=35.1039260969977, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI47155554, Length=338, Percent_Identity=31.9526627218935, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1790710, Length=456, Percent_Identity=37.280701754386, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI87082123, Length=390, Percent_Identity=35.3846153846154, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=347, Percent_Identity=33.1412103746398, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=223, Percent_Identity=26.0089686098655, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24661038, Length=334, Percent_Identity=30.8383233532934, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21355725, Length=453, Percent_Identity=28.9183222958057, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI221379063, Length=306, Percent_Identity=33.9869281045752, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221379062, Length=306, Percent_Identity=33.9869281045752, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21357381, Length=306, Percent_Identity=33.9869281045752, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24662227, Length=418, Percent_Identity=27.7511961722488, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20129969, Length=421, Percent_Identity=28.7410926365796, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21355645, Length=423, Percent_Identity=28.6052009456265, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24662223, Length=423, Percent_Identity=28.6052009456265, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI161077148, Length=427, Percent_Identity=27.8688524590164, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20130057, Length=427, Percent_Identity=27.8688524590164, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20129963, Length=422, Percent_Identity=27.9620853080569, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI19922386, Length=438, Percent_Identity=26.4840182648402, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646701, Length=216, Percent_Identity=32.8703703703704, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646703, Length=216, Percent_Identity=32.8703703703704, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358201, Length=216, Percent_Identity=32.8703703703704, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_MYCBO (Q7VEN5)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855885.1
- ProteinModelPortal:   Q7VEN5
- SMR:   Q7VEN5
- EnsemblBacteria:   EBMYCT00000017470
- GeneID:   1091360
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2236
- GeneTree:   EBGT00050000016870
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- ProtClustDB:   PRK00913
- BioCyc:   MBOV233413:MB2236-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53448; Mature: 53317

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 291-291 ACT_SITE 365-365

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEI
CCCCCCCCCCCHHHECCCCCCCCCEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHH
EAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSS
HHHHHHHCCCCCCCCHHEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
EAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDAGLRKITVLCCAKDAKKR
HHHHHHHHHCCCCCCHHHHHHHEEEECHHHHHHCCCCCCCCCCCCEEEEEEEECCHHHHH
ALHGAAVATAVATARDLVNTPPSHLFPAELAKRAKTLSESVGLDVEVIDEKALKKAGYGG
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCCC
VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMT
EEEECCCCCCCHHHHHHHHHCHHHHCCHHHHHEEEEEECCEEECCCCEEECCCHHHHHHH
SDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNT
HCCCCHHHHHHHHHHHHHHCCCHHHEEECCCCCCCCCCHHCCCHHHHHHCCCCEEEEEEC
DAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRIPGVMGSDEFRDRVAAISQR
CCCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHH
VGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEI
CCCCCCCCCCHHHECCCCCCCCCEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHH
EAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSS
HHHHHHHCCCCCCCCHHEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
EAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDAGLRKITVLCCAKDAKKR
HHHHHHHHHCCCCCCHHHHHHHEEEECHHHHHHCCCCCCCCCCCCEEEEEEEECCHHHHH
ALHGAAVATAVATARDLVNTPPSHLFPAELAKRAKTLSESVGLDVEVIDEKALKKAGYGG
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCCC
VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMT
EEEECCCCCCCHHHHHHHHHCHHHHCCHHHHHEEEEEECCEEECCCCEEECCCHHHHHHH
SDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNT
HCCCCHHHHHHHHHHHHHHCCCHHHEEECCCCCCCCCCHHCCCHHHHHHCCCCEEEEEEC
DAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRIPGVMGSDEFRDRVAAISQR
CCCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHH
VGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972