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The map label for this gene is 121638093

Identifier: 121638093

GI number: 121638093

Start: 2455834

End: 2456970

Strand: Direct

Name: 121638093

Synonym: BCG_2228

Alternate gene names: NA

Gene position: 2455834-2456970 (Clockwise)

Preceding gene: 121638090

Following gene: 121638094

Centisome position: 56.14

GC content: 67.28

Gene sequence:

>1137_bases
GTGTACGATTCCTTGGACTTCGACGCCCTCGAGGCCGCCGGAATTGCCAACCCACGCGAGCGGGCCGGCTTGCTCACCTA
CCTGGATGAGCTTGGCTTCACGGTCGAAGAGATGGTGCAAGCCGAACGCCGCGGCCGGTTGTTCGGGCTGGCCGGTGACG
TCCTGCTATGGTCCGGGCCCCCGATCTACACCCTGGCGACCGCGGCTGACGAACTGGGGTTGTCAGCCGACGACGTCGCA
CGCGCGTGGAGTTTGCTCGGCCTCACCGTCGCGGGTCCCGACGTTCCCACGCTGAGCCAGGCCGACGTCGACGCCCTGGC
GACCTGGGTCGCACTGAAGGCGCTGGTGGGTGAGGACGGCGCATTCGGCCTGCTGCGAGTGCTCGGCACTGCCATGGCCC
GACTCGCCGAGGCCGAGTCGACCATGATCCGCGCCGGGTCACCGAACATCCAAATGACGCACACCCACGACGAACTTGCC
ACGGCACGGGCCTATCGCGCGGCTGCGGAGTTCGTCCCCCGGATCGGTGCGCTGATCGACACCGTCCACCGTCACCACCT
GGCCAGCGCACGAACCTACTTTGAAGGCGTCATTGGCGACACGTCGGCAAGCGTGACGTGCGGTATCGGCTTTGCGGATC
TGTCCAGCTTCACCGCGTTGACCCAGGCGCTCACCCCCGCGCAGTTGCAGGACCTGCTCACCGAATTCGACGCCGCCGTC
ACCGACGTGGTGCATGCCGACGGTGGCCGGTTGGTGAAGTTCATCGGCGACGCCGTGATGTGGGTGAGCTCGTCGCCCGA
ACGACTGGTGCGGGCGGCGGTGGATCTCGTCGATCATCCGGGTGCGCGCGCGGCCGAACTGCAGGTCCGTGCCGGTCTTG
CCTATGGCACGGTGCTGGCCCTTAACGGTGACTACTTCGGCAACCCGGTCAACCTGGCTGCGCGCCTGGTGGCGGCCGCA
GCGCCAGGGCAGATCCTGGCCGCAGCGCAACTCCGCGACATGTTGCCAGACTGGCCTGCCCTCGCCCATGGCCCATTGAC
GCTCAAGGGGTTTGACGCCCCGGTGATGGCCTTCGAACTGCACGACAACCCTCGTGCGAGGGATGCTGACACGCCAAGCC
CCGCCGCCAGTGATTAG

Upstream 100 bases:

>100_bases
AGCTCGCGATGGCGGTCTTCCAGCGGTCCGTGTATCAGCTCTGGCACATCGCTCACGGCGTCCCACCCTAATGGGCGTCC
CTGCTGGCACACTTAGGCAG

Downstream 100 bases:

>100_bases
GGTGGTTGCCCGTGACCACCGAACCGGGTTACCTATCCCCCTCCGTCGCCGTCGCGACCTCGATGCCGAAACGTGGTGTC
GGCGCTGCGGTGTTGATCGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVA
RAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELA
TARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV
TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAA
APGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHDNPRARDADTPSPAASD

Sequences:

>Translated_378_residues
MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVA
RAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELA
TARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV
TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAA
APGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHDNPRARDADTPSPAASD
>Mature_378_residues
MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVA
RAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELA
TARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV
TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAA
APGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHDNPRARDADTPSPAASD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2212_MYCTU (P64265)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   E70786
- RefSeq:   NP_216728.1
- RefSeq:   NP_336740.1
- ProteinModelPortal:   P64265
- SMR:   P64265
- EnsemblBacteria:   EBMYCT00000002338
- EnsemblBacteria:   EBMYCT00000070730
- GeneID:   887979
- GeneID:   924157
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2268
- KEGG:   mtu:Rv2212
- TIGR:   MT2268
- TubercuList:   Rv2212
- GeneTree:   EBGT00050000014811
- HOGENOM:   HBG565223
- OMA:   VGDEVMF
- ProtClustDB:   CLSK791701
- InterPro:   IPR001054
- Gene3D:   G3DSA:3.30.70.1230
- SMART:   SM00044

Pfam domain/function: PF00211 Guanylate_cyc; SSF55073 A/G_cyclase

EC number: NA

Molecular weight: Translated: 39775; Mature: 39775

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS50125 GUANYLATE_CYCLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCEEEECCC
PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG
CCEEEEHHHHHHCCCHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID
HHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV
HHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA
HHHHCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEE
LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL
ECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEE
HDNPRARDADTPSPAASD
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCEEEECCC
PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG
CCEEEEHHHHHHCCCHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID
HHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV
HHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA
HHHHCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEE
LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL
ECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEE
HDNPRARDADTPSPAASD
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036