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The map label for this gene is 121637888

Identifier: 121637888

GI number: 121637888

Start: 2228133

End: 2229629

Strand: Reverse

Name: 121637888

Synonym: BCG_2021c

Alternate gene names: NA

Gene position: 2229629-2228133 (Counterclockwise)

Preceding gene: 121637889

Following gene: 121637887

Centisome position: 50.97

GC content: 64.73

Gene sequence:

>1497_bases
ATGGACTCACCGACCAACGACGGCACGTGTGACGCCCATCCTGTGACAGATGAGCCTTTCATCGATGTGCGCGAAACCCA
CACCGCAGTGGTTGTGTTGGCCGGCGACCGGGCGTTCAAGGCGAAAAAGCCTGTGGTGACGGATTTCTGCGACTTCCGCA
CGGCGGAACAGCGTGAGCGCGCCTGTATCCGGGAATTCGAGTTGAATAGTCGGCTGGCCGCGCAGAGCTACTTGGGCATT
GCCCATCTCAGCGATCCAAGCGGCGGGCACGCCGAACCGGTCGTCGTCATGCGGCGTTACCGCGACAAGCAGCGGCTGGC
GTCGATGGTGACCGCCGGCCTGCCGGTCGAGGGTGCCCTGGACGCGATCGCTGAGGTGTTGGCCCGGTTTCACCAGCGCG
CACAGCGTAACCGGTGCATCGATACTCAAGGCGAGGTCGGTGCGGTGGCGCGGCGTTGGCACGAAAACCTGGCCGAACTT
CGCCACCACGCGGACAAAGTGGTCTCCGGGGATGTGATTCGGCGGATTGAACACATGGTCGACGAATTCGTTTCCGGGCG
CGAGGTTTTGTTCGCCGGCCGGATCAAAGAAGGTTGTATTGTAGACGGCCACGCGGATCTACTGGCCGATGACATCTTCT
TGGTGGATGGCGAACCGGCGCTGCTGGATTGCTTGGAGTTCGAAGACGAGCTTCGCTACCTCGACCGCATCGACGACGCC
GCCTTTTTGGCCATGGATCTGGAGTTCTTGGGCCGCAAAGATCTTGGGGACTACTTCCTGGCCGGCTATGCGGTGCGTTC
GGGTGATACCGCCCCGGCGTCGCTGCGCGACTTCTACATTGCTTATCGCGCGGTGGTGCGCGCGAAAGTCGAGTGCGTGC
GATTCTCCCAGGGCAAACCGGAGGCCGCTGCGGACGCCGTGCGCCACCTGATCATCGCCACCCAACACCTACAGCACGCT
ACGGTCCGGTTGGCGCTGGTCGGTGGCAATCCGGGCACCGGCAAGTCGACCCTGGCCCGCGGGGTCGCCGAACTGGTGGG
GGCGCAGGTGATCTCAACCGACGATGTGCGCCGGCGGCTACGCGATTGCGGAGTAATCACCGGGGAGCCCGGCGTTTTGG
ACTCCGGGCTCTACAGTCGTGCCAACGTTGTGGCGGTCTACCAGGAGGCGCTGCGCAAAGCCCGCCTGCTCTTGGGTAGT
GGGCACTCAGTGATCCTCGACGGTACCTGGGGTGATCCGCAGATGCGCGCCTGCGCCCGGCGTCTCGCGGCGGACACGCA
CTCGGCGATTGTCGAATTCAGGTGTTCGGCGACGGTTGACGTGATGGCCGACAGAATCGTTGCTAGAGCCGGGGGCAACT
CCGACGCCACCGCCGAGATCGCGGCGGCCTTGGCCGCCCGGCAAGCGGACTGGGACACCGGGCACCGGATCGACACGGCG
GGGCCGCGTGAGCGCTCCGTGGGACAGGCCTACCACATCTGGCGCAGCGCGATCTGA

Upstream 100 bases:

>100_bases
CGGCATGCTTCTGGGGTCGGTCAGTAACGCGGTCTTACACGCCGCGCGGGTGCCAGTGATCGTGGCACGGCAGTCGTGAC
TACTTGGCTTGGCTACCGCC

Downstream 100 bases:

>100_bases
GAACGCCGAAAGGAAAACCGATGCCAACCATCACTGTCAGCAGCACATCGTCGCTGTGTGGTCAAGCGCTCTCGGGCAAC
CCGACTTTCGCCGAGCATCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGI
AHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAEL
RHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDA
AFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHA
TVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGS
GHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTA
GPRERSVGQAYHIWRSAI

Sequences:

>Translated_498_residues
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGI
AHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAEL
RHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDA
AFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHA
TVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGS
GHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTA
GPRERSVGQAYHIWRSAI
>Mature_498_residues
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGI
AHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAEL
RHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDA
AFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHA
TVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGS
GHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTA
GPRERSVGQAYHIWRSAI

Specific function: Some isolated peptides of this protein are able to bind to human U937 monocytoblastic and A549 epithelial cell lines

COG id: COG2187

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Secreted, cell wall

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2004_MYCTU (P0A5F9)

Other databases:

- EMBL:   U62548
- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   B70759
- RefSeq:   NP_216520.1
- RefSeq:   NP_336523.1
- ProteinModelPortal:   P0A5F9
- SMR:   P0A5F9
- EnsemblBacteria:   EBMYCT00000001316
- EnsemblBacteria:   EBMYCT00000072885
- GeneID:   888817
- GeneID:   923377
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2060
- KEGG:   mtu:Rv2004c
- TIGR:   MT2060
- TubercuList:   Rv2004c
- GeneTree:   EBGT00050000015587
- HOGENOM:   HBG481271
- OMA:   YVRAKVT
- ProtClustDB:   CLSK871993
- InterPro:   IPR011009
- InterPro:   IPR010488

Pfam domain/function: PF06414 Zeta_toxin; SSF56112 Kinase_like

EC number: NA

Molecular weight: Translated: 54423; Mature: 54423

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRER
CCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCCCCCHHHHHHCCCHHHHHH
ACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGAL
HHHHHHHCCCHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDA
HHHHCCCEEEEECCCCCCCEECCCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCH
AFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKP
HHHHHHHHHHCCCCCCHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRL
HHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCCHHHHHHHHHHHHCCHHCCHHHHHHHH
RDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACAR
HHCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
RLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTA
HHHCCHHHHHHHEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
GPRERSVGQAYHIWRSAI
CCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRER
CCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCCCCCHHHHHHCCCHHHHHH
ACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGAL
HHHHHHHCCCHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDA
HHHHCCCEEEEECCCCCCCEECCCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCH
AFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKP
HHHHHHHHHHCCCCCCHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRL
HHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCCHHHHHHHHHHHHCCHHCCHHHHHHHH
RDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACAR
HHCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
RLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTA
HHHCCHHHHHHHEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
GPRERSVGQAYHIWRSAI
CCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036