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The map label for this gene is argH

Identifier: 121637567

GI number: 121637567

Start: 1877906

End: 1879318

Strand: Direct

Name: argH

Synonym: BCG_1698

Alternate gene names: 121637567

Gene position: 1877906-1879318 (Clockwise)

Preceding gene: 121637566

Following gene: 121637568

Centisome position: 42.93

GC content: 71.13

Gene sequence:

>1413_bases
GTGAGCACCAACGAGGGGTCGCTGTGGGGCGGGCGGTTCGCCGGCGGCCCGTCCGACGCGCTGGCCGCGCTGAGCAAGTC
CACCCACTTCGACTGGGTGCTGGCCCCCTACGACCTCACCGCGTCGCGGGCGCACACCATGGTGCTGTTTCGGGCCGGGC
TGCTCACCGAGGAGCAACGCGACGGGCTGCTCGCCGGCCTGGACAGCCTCGCCCAAGACGTCGCCGACGGCAGCTTCGGC
CCGCTGGTCACCGACGAGGACGTGCATGCCGCGCTGGAGCGGGGCCTGATCGACCGGGTCGGACCGGACCTGGGCGGCCG
GCTGCGGGCCGGGCGCTCGCGCAACGACCAGGTGGCCGCGCTGTTTCGGATGTGGCTGCGCGACGCGGTGCGCCGGGTCG
CCACCGGTGTGCTCGACGTGGTCGGTGCGCTGGCAGAGCAGGCCGCCGCACACCCGAGCGCCATCATGCCCGGCAAAACC
CACCTGCAGTCCGCCCAGCCGATCCTGCTGGCACACCATCTGCTCGCGCACGCCCACCCCCTGCTGCGCGACCTGGACCG
CATCGTCGACTTCGACAAACGCGCGGCGGTGTCCCCGTACGGCTCGGGCGCCTTGGCCGGCTCGTCGCTGGGCCTGGATC
CCGACGCGATCGCCGCGGACCTCGGTTTCTCGGCTGCCGCGGACAACTCCGTCGACGCGACCGCCGCCCGCGACTTCGCC
GCCGAGGCGGCGTTCGTGTTCGCCATGATCGCCGTCGACCTGTCCCGGCTGGCTGAGGACATCATCGTCTGGAGCTCGAC
GGAATTCGGCTACGTCACGTTGCATGACTCGTGGTCCACCGGTAGCTCGATCATGCCGCAGAAGAAGAATCCGGACATCG
CCGAGCTGGCCCGCGGCAAGTCCGGGCGGCTGATCGGAAACCTGGCCGGGCTGCTGGCCACCCTGAAAGCCCAGCCCCTG
GCCTACAACCGCGACCTGCAGGAAGACAAGGAGCCGGTGTTCGATTCGGTGGCCCAGCTGGAGCTGCTGCTGCCGGCGAT
GGCCGGGCTGGTGGCCAGCCTGACCTTCAATGTCCAGCGGATGGCGGAGCTGGCCCCGGCCGGCTATACGTTGGCCACCG
ATCTCGCCGAATGGCTTGTGCGGCAAGGTGTTCCGTTTAGGTCCGCGCATGAGGCCGCGGGTGCGGCGGTGCGTGCGGCC
GAACAGCGCGGCGTGGGGCTGCAGGAACTCACCGACGACGAGCTGGCCGCCATCAGCCCCGAGCTGACCCCGCAAGTCCG
CGAGGTGCTGACCATCGAAGGCTCGGTGTCGGCCCGCGATTGCCGGGGTGGCACCGCGCCGGGCCGGGTTGCCGAGCAAC
TGAACGCCATTGGTGAAGCCGCCGAGCGGCTGCGCCGCCAGCTGGTGCGCTGA

Upstream 100 bases:

>100_bases
GCCCGCCGGGATCTGCGGTGACGGTTCTCCCGCGAGCAGACGCAGAATCGCACCGCCACGCCCGTCGGCGTGCGATTCTG
CGTCTGCTCGCCACAGAAAA

Downstream 100 bases:

>100_bases
GGGGGCCTCGAAACTTTGCCGGCCAGTTCCAGGCGGGCTAAACTTCGGGCTCTAGGCGACCCGGTTGAACCATTCGGCCT
CGATGTGCGTGTCAAAGGGG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLFRAGLLTEEQRDGLLAGLDSLAQDVADGSFG
PLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAAHPSAIMPGKT
HLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFA
AEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPL
AYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAA
EQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRVAEQLNAIGEAAERLRRQLVR

Sequences:

>Translated_470_residues
MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLFRAGLLTEEQRDGLLAGLDSLAQDVADGSFG
PLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAAHPSAIMPGKT
HLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFA
AEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPL
AYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAA
EQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRVAEQLNAIGEAAERLRRQLVR
>Mature_469_residues
STNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLFRAGLLTEEQRDGLLAGLDSLAQDVADGSFGP
LVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAAHPSAIMPGKTH
LQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFAA
EAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLA
YNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAAE
QRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRVAEQLNAIGEAAERLRRQLVR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=43.2314410480349, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=43.2314410480349, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=40.8296943231441, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=40.3930131004367, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI1790398, Length=459, Percent_Identity=41.8300653594771, Blast_Score=323, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=39.6514161220044, Blast_Score=327, Evalue=3e-90,
Organism=Drosophila melanogaster, GI221473854, Length=461, Percent_Identity=40.997830802603, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI78706858, Length=461, Percent_Identity=40.997830802603, Blast_Score=342, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_MYCBO (P0A4Z1)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855339.1
- ProteinModelPortal:   P0A4Z1
- SMR:   P0A4Z1
- EnsemblBacteria:   EBMYCT00000015229
- GeneID:   1092631
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1687
- GeneTree:   EBGT00050000016253
- HOGENOM:   HBG539632
- OMA:   MPGRTHL
- ProtClustDB:   PRK00855
- BioCyc:   MBOV233413:MB1687-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 49775; Mature: 49644

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLFRAGLLTEEQR
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHH
DGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAA
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LFRMWLRDAVRRVATGVLDVVGALAEQAAAHPSAIMPGKTHLQSAQPILLAHHLLAHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
LLRDLDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFA
HHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
AEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVQR
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAAEQRGVGLQELTDDELAAISP
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHCCC
ELTPQVREVLTIEGSVSARDCRGGTAPGRVAEQLNAIGEAAERLRRQLVR
CCCHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972