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The map label for this gene is hisI

Identifier: 121637513

GI number: 121637513

Start: 1810900

End: 1811247

Strand: Direct

Name: hisI

Synonym: BCG_1644

Alternate gene names: 121637513

Gene position: 1810900-1811247 (Clockwise)

Preceding gene: 121637512

Following gene: 121637514

Centisome position: 41.4

GC content: 62.07

Gene sequence:

>348_bases
ATGACACTCGACCCAAAGATCGCGGCGCGGTTGAAGCGTAATGCCGACGGACTGGTTACCGCCGTCGTCCAGGAGCGGGG
CAGCGGTGACGTGCTGATGGTTGCCTGGATGAACGACGAGGCCTTGGCCCGTACCCTGCAAACCCGTGAGGCCACTTACT
ATTCGCGATCCCGTGCCGAACAATGGGTCAAGGGCGCGACGTCCGGCCACACCCAGCACGTTCACTCGGTGCGCCTGGAT
TGTGACGGCGACGCCGTATTGTTGACGGTTGACCAGGTCGGCGGTGCCTGCCATACCGGCGATCACAGTTGCTTCGATGC
CGCGGTGTTGTTAGAACCCGACGACTAA

Upstream 100 bases:

>100_bases
CGGGGGCCGATGCAGTGTTGGCGGCCAGCGTCTTTCACTTCCGGGAGCTGACGATCGGTCAGGTGAAGGCGGCCCTGGCC
GCGGAAGGAATCACCGTGCG

Downstream 100 bases:

>100_bases
CCCGCCGCGGAAAGACTGGGGCTAGCGGCTCGCGGCGCAACAGATTGCAGTGGTCGCCCGCGAGGCAAGAGTGCCCATCG
ACACGCCGCCGAGCGAGCGC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 115; Mature: 114

Protein sequence:

>115_residues
MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLD
CDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD

Sequences:

>Translated_115_residues
MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLD
CDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD
>Mature_114_residues
TLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLDC
DGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=43.4782608695652, Blast_Score=92, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=37.3626373626374, Blast_Score=64, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_MYCBO (P0A5B4)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855285.1
- ProteinModelPortal:   P0A5B4
- SMR:   P0A5B4
- EnsemblBacteria:   EBMYCT00000014796
- GeneID:   1092540
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1632
- GeneTree:   EBGT00050000017128
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   MBOV233413:MB1632-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 12465; Mature: 12334

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAE
CCCCHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
QWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD
HHHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
TLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAE
CCCHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
QWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD
HHHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972