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The map label for this gene is pgk

Identifier: 121637367

GI number: 121637367

Start: 1639137

End: 1640375

Strand: Direct

Name: pgk

Synonym: BCG_1498

Alternate gene names: 121637367

Gene position: 1639137-1640375 (Clockwise)

Preceding gene: 121637366

Following gene: 121637368

Centisome position: 37.47

GC content: 64.57

Gene sequence:

>1239_bases
ATGAGCGTTGCAAACCTCAAGGATCTACTCGCCGAAGGTGTTTCGGGGCGTGGAGTGCTGGTGCGCTCCGATCTCAACGT
TCCGCTCGACGAGGACGGCACCATTACCGATGCGGGCCGCATCATCGCGTCGGCGCCGACGTTGAAGGCGTTGCTCGACG
CCGACGCCAAGGTGGTGGTTGCCGCGCACTTGGGACGTCCCAAGGACGGGCCGGACCCGACACTGTCGCTGGCGCCGGTC
GCCGTGGCGCTGGGTGAGCAACTCGGCCGGCACGTCCAGCTGGCTGGAGACGTTGTCGGCGCCGATGCGCTGGCCCGCGC
CGAGGGGCTCACCGGCGGCGACATCCTGCTGCTGGAGAACATCCGCTTCGACAAACGCGAAACCAGCAAGAACGATGACG
ACCGGCGGGCACTGGCCAAGCAGCTGGTCGAACTGGTCGGAACGGGAGGCGTTTTCGTCTCCGACGGCTTTGGGGTGGTG
CACCGCAAGCAAGCCTCGGTCTATGACATCGCAACCCTGTTGCCGCACTACGCCGGCACGCTGGTCGCCGACGAGATGCG
GGTACTGGAGCAGTTGACCAGCTCGACCCAGCGGCCCTATGCGGTAGTGCTCGGCGGATCAAAGGTGTCCGACAAGCTGG
GTGTCATCGAGTCGCTGGCGACCAAGGCGGACAGCATTGTGATTGGCGGCGGAATGTGCTTCACATTCCTTGCTGCACAG
GGATTTTCGGTTGGCACATCGCTGCTGGAAGACGACATGATCGAAGTCTGTCGCGGGCTGCTGGAAACCTATCACGACGT
GTTGCGGCTGCCCGTGGATCTAGTGGTCACGGAGAAGTTCGCCGCCGACTCGCCGCCCCAGACGGTCGACGTCGGCGCTG
TGCCCAATGGCTTGATGGGCCTGGATATCGGGCCGGGATCGATCAAACGGTTCAGCACGCTGCTGTCCAACGCCGGGACC
ATCTTCTGGAACGGGCCGATGGGAGTATTCGAGTTCCCGGCTTATGCGGCCGGCACCAGAGGCGTCGCCGAGGCGATCGT
CGCCGCCACCGGCAAAGGGGCGTTTAGTGTGGTCGGCGGCGGTGACTCCGCGGCCGCAGTGCGCGCGATGAACATCCCCG
AGGGCGCCTTCTCACACATATCCACCGGCGGCGGTGCCTCGCTGGAATACCTTGAGGGCAAGACGCTTCCCGGCATCGAG
GTACTGAGCCGTGAGCAGCCAACCGGAGGAGTTTTGTGA

Upstream 100 bases:

>100_bases
TCGACGACCAGGCCAAGGTGGTGTCGTGGTACGACAACGAGTGGGGCTACTCCAACCGCCTGGTTGATCTGGTCACGCTG
GTCGGCAAGTCGCTCTAGCC

Downstream 100 bases:

>100_bases
GCCGCAAGCCGCTGATAGCCGGCAACTGGAAGATGAACCTCAACCACTACGAGGCGATCGCGCTGGTGCAAAAGATCGCG
TTCTCGTTGCCGGACAAGTA

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVVAAHLGRPKDGPDPTLSLAPV
AVALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLENIRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVV
HRKQASVYDIATLLPHYAGTLVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQ
GFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMGLDIGPGSIKRFSTLLSNAGT
IFWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGGGDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIE
VLSREQPTGGVL

Sequences:

>Translated_412_residues
MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVVAAHLGRPKDGPDPTLSLAPV
AVALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLENIRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVV
HRKQASVYDIATLLPHYAGTLVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQ
GFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMGLDIGPGSIKRFSTLLSNAGT
IFWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGGGDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIE
VLSREQPTGGVL
>Mature_411_residues
SVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVVAAHLGRPKDGPDPTLSLAPVA
VALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLENIRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVH
RKQASVYDIATLLPHYAGTLVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQG
FSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMGLDIGPGSIKRFSTLLSNAGTI
FWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGGGDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIEV
LSREQPTGGVL

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family

Homologues:

Organism=Homo sapiens, GI4505763, Length=420, Percent_Identity=38.3333333333333, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI31543397, Length=411, Percent_Identity=39.9026763990268, Blast_Score=263, Evalue=2e-70,
Organism=Escherichia coli, GI1789294, Length=406, Percent_Identity=41.6256157635468, Blast_Score=261, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI17508823, Length=408, Percent_Identity=40.1960784313725, Blast_Score=278, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6319857, Length=405, Percent_Identity=38.5185185185185, Blast_Score=255, Evalue=8e-69,
Organism=Drosophila melanogaster, GI17136394, Length=418, Percent_Identity=38.9952153110048, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24581203, Length=413, Percent_Identity=36.0774818401937, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): PGK_MYCBO (P65701)

Other databases:

- EMBL:   BX248338
- RefSeq:   NP_855124.1
- ProteinModelPortal:   P65701
- SMR:   P65701
- EnsemblBacteria:   EBMYCT00000018047
- GeneID:   1092329
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1472
- GeneTree:   EBGT00050000017271
- HOGENOM:   HBG453500
- OMA:   NCAIILP
- ProtClustDB:   PRK00073
- BioCyc:   MBOV233413:MB1472-MONOMER
- BRENDA:   2.7.2.3
- GO:   GO:0005737
- GO:   GO:0006096
- HAMAP:   MF_00145
- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824
- Gene3D:   G3DSA:3.40.50.1270
- Gene3D:   G3DSA:3.40.50.1260
- PANTHER:   PTHR11406
- PIRSF:   PIRSF000724
- PRINTS:   PR00477

Pfam domain/function: PF00162 PGK; SSF53748 PGK

EC number: =2.7.2.3

Molecular weight: Translated: 42513; Mature: 42382

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: BINDING 40-40 BINDING 122-122 BINDING 162-162 BINDING 212-212 BINDING 300-300 BINDING 331-331

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVV
CCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECCCHHEECCHHHHHHHCCCCEEEE
AAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLEN
EEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCHHCHHHHHHHCCCCCCCEEEEEC
IRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVHRKQASVYDIATLLPHYAGT
CCCCCHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHH
LVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQ
HHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHC
GFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHCCCCCCCEEECCCCCCCCEE
LDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGG
EECCCCHHHHHHHHHHCCCEEEECCCCCHHCCCCHHCCCHHHHHHHHHHCCCCCEEEEEC
GDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIEVLSREQPTGGVL
CCCCCEEEEECCCCHHHHHCCCCCCCEEEEECCCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure 
SVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVV
CCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECCCHHEECCHHHHHHHCCCCEEEE
AAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLEN
EEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCHHCHHHHHHHCCCCCCCEEEEEC
IRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVHRKQASVYDIATLLPHYAGT
CCCCCHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHH
LVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQ
HHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHC
GFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHCCCCCCCEEECCCCCCCCEE
LDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGG
EECCCCHHHHHHHHHHCCCEEEECCCCCHHCCCCHHCCCHHHHHHHHHHCCCCCEEEEEC
GDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIEVLSREQPTGGVL
CCCCCEEEEECCCCHHHHHCCCCCCCEEEEECCCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972