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The map label for this gene is tpiA [H]

Identifier: 121637368

GI number: 121637368

Start: 1640372

End: 1641157

Strand: Direct

Name: tpiA [H]

Synonym: BCG_1499

Alternate gene names: 121637368

Gene position: 1640372-1641157 (Clockwise)

Preceding gene: 121637367

Following gene: 121637370

Centisome position: 37.5

GC content: 64.25

Gene sequence:

>786_bases
GTGAGCCGCAAGCCGCTGATAGCCGGCAACTGGAAGATGAACCTCAACCACTACGAGGCGATCGCGCTGGTGCAAAAGAT
CGCGTTCTCGTTGCCGGACAAGTATTACGACCGGGTTGACGTCGCGGTGATCCCGCCGTTTACCGACCTGCGCAGCGTGC
AAACCCTGGTCGACGGCGACAAGCTGCGGTTGACCTATGGTGCACAAGACTTGTCACCACATGACTCCGGTGCCTATACG
GGTGACGTCAGCGGCGCCTTTCTGGCCAAGTTGGGGTGCAGTTACGTTGTCGTCGGGCACTCCGAGCGGCGCACCTATCA
CAACGAGGATGACGCGCTGGTGGCCGCCAAAGCCGCCACCGCACTCAAGCATGGCTTGACCCCAATCGTGTGTATTGGCG
AGCACCTCGACGTCCGCGAGGCGGGAAATCATGTGGCCCACAACATCGAACAGTTGCGTGGATCGCTGGCCGGGCTATTG
GCCGAGCAGATCGGCAGCGTCGTCACCGCCTACGAACCGGTCTGGGCGATCGGCACCGGGCGGGTGGCCAGCGCCGCCGA
CGCCCAGGAGGTGTGTGCGGCGATCCGAAAAGAGTTGGCCTCGTTGGCCTCGCCGAGGATTGCCGATACGGTGCGGGTGC
TCTACGGCGGCTCGGTGAACGCCAAAAACGTCGGCGACATCGTGGCCCAGGATGACGTCGATGGTGGCCTGGTCGGCGGG
GCGTCGCTGGACGGGGAGCATTTCGCGACGCTGGCCGCGATTGCGGCCGGTGGTCCGTTGCCGTAG

Upstream 100 bases:

>100_bases
ACATATCCACCGGCGGCGGTGCCTCGCTGGAATACCTTGAGGGCAAGACGCTTCCCGGCATCGAGGTACTGAGCCGTGAG
CAGCCAACCGGAGGAGTTTT

Downstream 100 bases:

>100_bases
CGGATCGCGGGCGTGCTACACCCGTAGACCTTCGAGTAGGGCCATAAATGCGCGTTCGACCTCGACTCTGGTCCGGTCTT
TGTCCGTCGCGTCCGCGATC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYT
GDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLL
AEQIGSVVTAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGG
ASLDGEHFATLAAIAAGGPLP

Sequences:

>Translated_261_residues
MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYT
GDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLL
AEQIGSVVTAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGG
ASLDGEHFATLAAIAAGGPLP
>Mature_260_residues
SRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTG
DVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLA
EQIGSVVTAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGGA
SLDGEHFATLAAIAAGGPLP

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=248, Percent_Identity=38.7096774193548, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI226529917, Length=249, Percent_Identity=38.9558232931727, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI1790353, Length=249, Percent_Identity=41.7670682730924, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17536593, Length=244, Percent_Identity=42.2131147540984, Blast_Score=171, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320255, Length=248, Percent_Identity=40.7258064516129, Blast_Score=162, Evalue=5e-41,
Organism=Drosophila melanogaster, GI28572008, Length=247, Percent_Identity=39.6761133603239, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28572006, Length=247, Percent_Identity=39.6761133603239, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28572004, Length=247, Percent_Identity=39.6761133603239, Blast_Score=154, Evalue=5e-38,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27391; Mature: 27260

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGD
CCCCCEEECCEEECCCHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCHHHHHHHHHHCCC
KLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAAT
EEEEEECCCCCCCCCCCCEECCCCHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
ALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVTAYEPVWAIGTG
HHHHCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
RVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGG
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCCCCCEEECCCCCCCEECC
ASLDGEHFATLAAIAAGGPLP
CCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGD
CCCCEEECCEEECCCHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCHHHHHHHHHHCCC
KLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAAT
EEEEEECCCCCCCCCCCCEECCCCHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
ALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVTAYEPVWAIGTG
HHHHCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
RVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGG
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCCCCCEEECCCCCCCEECC
ASLDGEHFATLAAIAAGGPLP
CCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]