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The map label for this gene is 121637249

Identifier: 121637249

GI number: 121637249

Start: 1507408

End: 1509015

Strand: Reverse

Name: 121637249

Synonym: BCG_1380c

Alternate gene names: NA

Gene position: 1509015-1507408 (Counterclockwise)

Preceding gene: 121637250

Following gene: 121637248

Centisome position: 34.5

GC content: 64.3

Gene sequence:

>1608_bases
ATGCCGGCGAAAAAGACCATGGCGCAACGCCTGGGCCAGGCACTCGAGACGATGACCCGTCAGTGCGGCCAGCTGCCCGA
GACCCCGGCGTATGGCTCCTGGTTGCTTGGGCGGGTGTCAGAAAGCCCGTCGCGTCGCTGGGTACGCATCAAGCGCATCG
TGACCGTCTATATCATGACGGCGAACCTGACCGGGATCGTGGTCGCGCTGCTAGTGGTGACCTTCGCTTTTCCGGTGCCT
AGCATCTACACCGACGCCCCATGGTGGGTCACCTTCGGGGTCGCACCGGCCTATGCGACGCTCGCACTGGCCATCGGCAC
CTACTGGATAACCACGCGAATCGTCAGAGCGTCCATACGGTGGGCGATCGAGGAACGCGCGCCGAGCCAGGCCGACGGGC
GCAACACCTTGCTGCTCCCGTTTCGAGTGGCAGCCGTCCACCTCATTCTGTGGGATATCGGCGGGGCGTTGTTGGCCACG
CTCTACGGGCTGGCCAACCGCGTATTCGTCACCATAATTTTGTTCTCGGTGACTATCTGCGGCGTTTTGGTAGCCACCAA
TTGCTACTTGTTCACCGAGTTCGCGCTGCGACCCGTAGCCGCTAAAGCACTCGAAGCGGGACGACCGCCACGACGGTTTG
CACCGGGCATCATGGGCCGAACGATGACGGTGTGGTCGCTAGGTTCAGGCGTGCCTGTGACCGGCATCGCCACGACAGCG
CTCTACGTCCTATTGGTGCACAATCTGACCGAAACGCAGCTCGCGTCGGCGGTGTTGATCCTGTCGATAACCACGTTGAT
CTTCGGGTTTCTCGTGATGTGGATTCTTGCTTGGCTGACGGCGGCGCCGGTGCGAGTGGTGCGCGCTGCGCTCAAGCGTG
TCGAGCAGGGGGATCTGCGAGGGGATCTGGTGGTGTTCGACGGCACCGAACTCGGTGAGCTGCAGCGTGGTTTCAACGCG
ATGGTCAACGGCCTGCGCGAGCGCGAACGCGTGCGCGACCTTTTCGGCCGCCACGTCGGACGCGAAGTCGCCGCCGCCGC
CGAGCGTGAACGACCACAGCTAGGCGGCGAAGACCGCCACGCCGCCGTCGTCTTCGTCGACATCGTCGGCTCCACCCAGC
TGGTGGACAACCAACCTGCCGCCCACGTGGTCAAGCTCCTCAACCGGTTTTTCGCGATCGTCGTCAACGAGGTCGACCGT
CACCACGGACTGATCAACAAGTTCGCAGGCGACGCCGCCCTGGCCATCTTCGGAGCCCCGAACCGCCTCGACCGTCCCGA
AGACGCCGCGCTGGCCGCCGCCCGGGCCATAGCCGATCGGCTGGCCAACGAGATGCCCGAGGTCCAAGCCGGCATCGGGG
TGGCGGCAGGCCAGATCGTCGCCGGCAATGTCGGCGCCAAGCAAAGATTCGAATACACAGTGGTCGGCAAGCCGGTCAAC
CAGGCGGCCCGATTGTGCGAACTGGCCAAATCACACCCCGCGCGATTGCTAGCATCCTCGGACACACTGCACGCTGCCAG
CGAAACCGAGCGTGCCCATTGGTCTTTGGGCGAGACGGTGACGCTGCGCGGACATGAGCAGCCGACTCGGCTGGCCGTGC
CCACCTAA

Upstream 100 bases:

>100_bases
GCCTGCTCAGTCGGCCGACATAGTCGGCGGTGCACTGGGCGATCACCAGACCCACACGATTTACCGTGGGGCGCATCCGA
CAGATTAGGCTGACGCCACC

Downstream 100 bases:

>100_bases
GCCGGGCAAACAACACGAGCGCGCCAACCGGTCGCACCCGACTCTTCGACAAACTAGTCTGACGCCACAATGTCGGCCAA
GAAGAGCACGGCGCAACGCT

Product: putative adenylate cyclase

Products: 3',5'-cyclic AMP; diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVP
SIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLAT
LYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA
LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNA
MVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDR
HHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN
QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT

Sequences:

>Translated_535_residues
MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVP
SIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLAT
LYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA
LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNA
MVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDR
HHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN
QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT
>Mature_534_residues
PAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPS
IYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATL
YGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTAL
YVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAM
VNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRH
HGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQ
AARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1319_MYCTU (P0A4Y2)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   C70769
- RefSeq:   NP_215835.1
- RefSeq:   NP_335809.1
- ProteinModelPortal:   P0A4Y2
- SMR:   P0A4Y2
- EnsemblBacteria:   EBMYCT00000002013
- EnsemblBacteria:   EBMYCT00000072857
- GeneID:   886911
- GeneID:   924697
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1361
- KEGG:   mtu:Rv1319c
- TIGR:   MT1361
- TubercuList:   Rv1319c
- GeneTree:   EBGT00050000015402
- HOGENOM:   HBG571123
- OMA:   RPPNRAV
- ProtClustDB:   CLSK791097
- InterPro:   IPR001054
- InterPro:   IPR003660
- Gene3D:   G3DSA:3.30.70.1230
- SMART:   SM00044
- SMART:   SM00304

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP; SSF55073 A/G_cyclase

EC number: 4.6.1.1

Molecular weight: Translated: 58098; Mature: 57967

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS50125 GUANYLATE_CYCLASE_2; PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x141bcea0)-; HASH(0x15a6d8d0)-; HASH(0x12875244)-; HASH(0x155c9bb0)-; HASH(0x14d830e8)-; HASH(0x15ab503c)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHEEHHHH
ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC
HHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEECCCCCCCHHHHHHH
LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP
EEEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEECCCCCCCCEEEEEECCCHH
QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT
HHHHHHHHHHCCCHHEEECCCCHHCCHHCCHHHCCCCCEEEEECCCCCCCCCCCH
>Mature Secondary Structure 
PAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHEEHHHH
ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC
HHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEECCCCCCCHHHHHHH
LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP
EEEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEECCCCCCCCEEEEEECCCHH
QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT
HHHHHHHHHHCCCHHEEECCCCHHCCHHCCHHHCCCCCEEEEECCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP

Specific reaction: ATP = 3',5'-cyclic AMP + diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036