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The map label for this gene is 121637248

Identifier: 121637248

GI number: 121637248

Start: 1505713

End: 1507338

Strand: Reverse

Name: 121637248

Synonym: BCG_1379c

Alternate gene names: NA

Gene position: 1507338-1505713 (Counterclockwise)

Preceding gene: 121637249

Following gene: 121637247

Centisome position: 34.46

GC content: 66.11

Gene sequence:

>1626_bases
ATGTCGGCCAAGAAGAGCACGGCGCAACGCTTGGGTCGGGTGCTGGAGACGGTGACCCGGCAGAGCGGCCGGCTGCCAGA
AACTCCCGCGTACGGCTCCTGGCTGCTTGGGCGGGTTTCGGAAAGCCAACGGCGCCGACGGGTACGGATCCAGGTCATGC
TGACCGCGCTGGTCGTGACCGCGAACCTGCTCGGCATCGGGGTTGCCCTGCTATTGGTGACGATCGCCATCCCCGAACCG
AGCATCGTTCGCGACACGCCACGGTGGCTCACGTTCGGGGTGGTACCGGGCTATGTCCTGCTAGCCCTCGCTTTGGGTAG
CTACGCACTGACCAGGCAGACCGTGCAAGCCCTGCGCTGGGCGATCGAAGGACGGAAACCGACTCGTGAGGAGGAGCGCC
GCACCTTCCTGGCCCCCTGGCGAGTCGCCGTGGGCCACCTCATGTTCTGGGGTGTTGGCACGGCGCTCTTGACGACACTC
TACGGCCTGATCAACAACGCGTTCATCCCGCGATTCCTGTTCGCGGTCAGCTTTTGCGGCGTATTGGTCGCAACCGCAAC
CTATCTGCATACCGAGTTCGCATTGCGCCCGTTCGCCGCCCAGGCGCTCGAGGCCGGGCCGCCGCCACGCCGGTTGGCGC
CGGGAATCCTGGGCCGGACCATGGTGGTGTGGCTGCTCGGTTCGGGAGTACCCGTCGTCGGCATCGCCCTGATGGCGATG
TTCGAAATGGTGCTGCTCAATCTCACTCGGATGCAGTTCGCGACGGGCGTGCTGATCATCTCGATGGTCACATTGGTGTT
CGGGTTCATCCTGATGTGGATCCTGGCCTGGCTGACGGCGACCCCGGTGCGGGTGGTGCGTGCGGCGCTGCGGCGCGTCG
AGCGGGGCGAGCTACGGACCAACCTGGTGGTCTTCGACGGCACCGAACTCGGCGAGCTGCAGCGTGGTTTCAACGCGATG
GTCGCCGGACTGCGGGAGCGCGAACGAGTGCGCGATCTGTTCGGCCGCCACGTCGGACGCGAAGTCGCCGCCGCCGCCGA
GCGTGAACGTTCGAAACTGGGCGGCGAAGAACGCCACGTCGCCGTCGTGTTCATCGACATCGTCGGCTCGACGCAATTGG
TGACCAGCCGGCCGCCGGCCGACGTCGTCAAGCTGCTCAACAAGTTCTTCGCGATTGTCGTCGACGAGGTCGACCGCCAC
CACGGATTGGTCAACAAGTTCGAGGGGGACGCGTCGCTAACCATCTTCGGCGCCCCGAACCGGCTTCCCTGTCCCGAAGA
CAAGGCACTGGCCGCCGCGCGGGCGATAGCCGATCGGCTGGTCAACGAAATGCCCGAGTGCCAGGCCGGGATCGGCGTGG
CGGCGGGGCAGGTCATTGCCGGCAACGTGGGTGCCCGAGAACGGTTCGAGTACACCGTGATCGGGGAGCCGGTCAACGAG
GCGGCCCGATTGTGCGAACTGGCCAAATCGCGTCCCGGCAAGTTGCTGGCTTCGGCACAGGCCGTGGACGCCGCAAGCGA
AGAGGAGCGCGCCCGTTGGTCTTTGGGTAGGCATGTGAAACTTCGTGGGCACGACCAACCGGTCCGGCTGGCCAAGCCGG
TCGGGCTGACCAAGCCGCGTAGGTAA

Upstream 100 bases:

>100_bases
GCAGCCGACTCGGCTGGCCGTGCCCACCTAAGCCGGGCAAACAACACGAGCGCGCCAACCGGTCGCACCCGACTCTTCGA
CAAACTAGTCTGACGCCACA

Downstream 100 bases:

>100_bases
CCTGCCCGAACCCACGACGACCCCATCACAATGTCGTTTTTCCGCCAGTCATGTCGGTGGGCGGGTGTAATTGTTGAAGG
GTGCACGACGACTTCGAACG

Product: putative adenylate cyclase

Products: 3',5'-cyclic AMP; diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEP
SIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTL
YGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM
FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAM
VAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRH
HGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE
AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR

Sequences:

>Translated_541_residues
MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEP
SIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTL
YGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM
FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAM
VAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRH
HGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE
AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR
>Mature_540_residues
SAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPS
IVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLY
GLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMF
EMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMV
AGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHH
GLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEA
ARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1318_MYCTU (P63527)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   B70769
- RefSeq:   NP_215834.1
- RefSeq:   NP_335807.1
- ProteinModelPortal:   P63527
- SMR:   P63527
- EnsemblBacteria:   EBMYCT00000001882
- EnsemblBacteria:   EBMYCT00000070870
- GeneID:   886910
- GeneID:   924688
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1359
- KEGG:   mtu:Rv1318c
- TIGR:   MT1359
- TubercuList:   Rv1318c
- GeneTree:   EBGT00050000015402
- HOGENOM:   HBG571123
- OMA:   TMFIPRF
- ProtClustDB:   CLSK791097
- GO:   GO:0005829
- InterPro:   IPR001054
- InterPro:   IPR003660
- Gene3D:   G3DSA:3.30.70.1230
- SMART:   SM00044
- SMART:   SM00304

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP; SSF55073 A/G_cyclase

EC number: 4.6.1.1

Molecular weight: Translated: 59333; Mature: 59201

Theoretical pI: Translated: 11.23; Mature: 11.23

Prosite motif: PS50125 GUANYLATE_CYCLASE_2; PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1453aee0)-; HASH(0x124e19f4)-; HASH(0x15aa80b8)-; HASH(0x124fb974)-; HASH(0x12c49960)-; HASH(0x15705ad8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHH
FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHE
NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN
EEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCC
RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCHHCCCEEECCCCCCCCEEEEEECCCHHH
AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR
HHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCCCHHCCCCCCCCCC
R
H
>Mature Secondary Structure 
SAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHH
FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHE
NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN
EEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCC
RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCHHCCCEEECCCCCCCCEEEEEECCCHHH
AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR
HHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCCCHHCCCCCCCCCC
R
H

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP

Specific reaction: ATP = 3',5'-cyclic AMP + diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036