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The map label for this gene is purM [H]

Identifier: 121636733

GI number: 121636733

Start: 934147

End: 935241

Strand: Direct

Name: purM [H]

Synonym: BCG_0861

Alternate gene names: 121636733

Gene position: 934147-935241 (Clockwise)

Preceding gene: 121636732

Following gene: 121636736

Centisome position: 21.35

GC content: 65.11

Gene sequence:

>1095_bases
ATGACGGATCTCGCAAAAGGCCCCGGAAAAGACCCGGGTAGTCGGGGTATCACCTACGCGTCGGCCGGGGTCGACATCGA
AGCCGGTGACCGCGCCATCGACCTGTTCAAGCCGCTCGCTTCGAAGGCCACCAGACCCGAAGTGCGCGGCGGGCTGGGGG
GATTCGCCGGACTGTTCACTCTCCGCGGCGACTACCGCGAACCGGTGCTGGCGGCCTCCAGCGACGGCGTCGGCACCAAA
CTCGCGATCGCTCAGGCGATGGATAAGCACGACACGGTGGGCCTGGACCTGGTGGCGATGGTGGTCGATGACTTGGTGGT
TTGCGGCGCCGAGCCGCTGTTCCTGTTGGATTACATCGCCGTCGGTCGGATCGTGCCGGAGCGACTCAGCGCGATCGTCG
CCGGTATCGCCGATGGGTGCATGCGTGCCGGCTGTGCGCTGCTTGGCGGCGAGACCGCAGAACATCCGGGCCTGATCGAG
CCCGATCACTACGATATCTCTGCCACCGGCGTCGGCGTCGTCGAGGCGGACAATGTGCTGGGTCCCGACCGGGTCAAACC
CGGCGACGTCATCATCGCGATGGGCTCGTCGGGTCTGCATTCCAATGGGTACTCGCTGGTCCGCAAGGTGTTGCTGGAGA
TCGACCGGATGAATCTGGCCGGTCATGTGGAGGAGTTCGGTCGCACCTTGGGCGAAGAGTTATTGGAGCCGACTCGCATC
TACGCCAAAGACTGTTTGGCCTTGGCCGCCGAAACCCGTGTCCGGACGTTTTGCCACGTCACCGGCGGCGGGCTCGCCGG
CAACCTGCAACGGGTCATCCCGCATGGCCTCATCGCCGAGGTCGACCGCGGCACCTGGACACCCGCGCCGGTATTCACCA
TGATTGCCCAGCGCGGCCGGGTCAGGCGCACAGAGATGGAGAAGACGTTCAACATGGGTGTCGGCATGATCGCCGTCGTT
GCCCCCGAAGACACGACGCGCGCCCTGGCCGTCCTGACCGCGCGGCACCTGGACTGCTGGGTATTGGGAACCGTCTGCAA
AGGCGGAAAACAAGGCCCGCGGGCAAAACTGGTTGGGCAGCACCCGAGATTCTAA

Upstream 100 bases:

>100_bases
CGCCAATGCGGCCCGCGGAGCCGCGCTGGGCGAACTCGCCGCCGACGACGAAGTCCCCGTTGGGCGCTGACAAAACGCAC
GCGCGGTAGCCTTTATCGCG

Downstream 100 bases:

>100_bases
GAACCAGACCTAACCGGGTCTAATGAGGTCAACGCCACGCCGATGGGAACCGAATCGGCACCGTGCGGGGGGCAGCTCCG
TGGTGCTAGCGCCGCCAGTC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MTDLAKGPGKDPGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLAASSDGVGTK
LAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIE
PDHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRI
YAKDCLALAAETRVRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVV
APEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQHPRF

Sequences:

>Translated_364_residues
MTDLAKGPGKDPGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLAASSDGVGTK
LAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIE
PDHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRI
YAKDCLALAAETRVRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVV
APEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQHPRF
>Mature_363_residues
TDLAKGPGKDPGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLAASSDGVGTKL
AIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEP
DHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRIY
AKDCLALAAETRVRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVVA
PEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQHPRF

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=44.5086705202312, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=44.5086705202312, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=44.5086705202312, Blast_Score=291, Evalue=7e-79,
Organism=Escherichia coli, GI1788845, Length=329, Percent_Identity=47.112462006079, Blast_Score=298, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17567511, Length=368, Percent_Identity=32.0652173913043, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=42.6900584795322, Blast_Score=263, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24582400, Length=271, Percent_Identity=38.0073800738007, Blast_Score=191, Evalue=5e-49,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38394; Mature: 38263

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLAKGPGKDPGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFT
CCCCCCCCCCCCCCCCCEEEECCCEECCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHHHE
LRGDYREPVLAASSDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIA
ECCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
VGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVGVVEADNVL
HHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCEEEECCCEEEECCCCC
GPDRVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRI
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YAKDCLALAAETRVRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGR
HHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHCCCHHHHCCCCCCCCCHHHHHHHHHCCC
VRRTEMEKTFNMGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQ
HHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCC
HPRF
CCCC
>Mature Secondary Structure 
TDLAKGPGKDPGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFT
CCCCCCCCCCCCCCCCEEEECCCEECCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHHHE
LRGDYREPVLAASSDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIA
ECCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
VGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVGVVEADNVL
HHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCEEEECCCEEEECCCCC
GPDRVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRI
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YAKDCLALAAETRVRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGR
HHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHCCCHHHHCCCCCCCCCHHHHHHHHHCCC
VRRTEMEKTFNMGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQ
HHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCC
HPRF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA