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The map label for this gene is ispA [C]

Identifier: 121610223

GI number: 121610223

Start: 3660477

End: 3661421

Strand: Direct

Name: ispA [C]

Synonym: Veis_3282

Alternate gene names: 121610223

Gene position: 3660477-3661421 (Clockwise)

Preceding gene: 121610222

Following gene: 121610224

Centisome position: 65.76

GC content: 72.49

Gene sequence:

>945_bases
ATGAGCGCCGCTTCCACGCTATCGGCTGCGGCGGCTCCGCTGGACCTGGGCGGCTGGCAGCAAAACCACCTGGCCCAGGT
GGAGCAGGCGCTGTCGCAATGGGTGGGCCATGGCGCGCCCGCCGGGCTGGGCGAGGCCATGCGCTATGCCGTGCTCGATG
GCGGCAAGCGCCTGCGGCCGCTGCTGGTGCTGGCCGCGTATCAGGCGGTCTGCAGCGGCCAGCCTGCACCCTGCGCCTGG
CACGATGCGGCGGCGCTGCGTGCCGCCTGCGCCGTGGAACTGATCCACGCCTATTCGCTGGTGCATGACGATCTGCCCTG
CATGGACAACGATGTGCTGCGCCGTGGCAAGCCCACGGCGCATGTGCGGTTCGGCCCGGCCCGGGCCCTGCTCGCAGGCG
ACGCGCTGCAAGCCTTTGCGTTCGAGTTGCTCACGCCCGAGGACATGCCCATCCCCGCCGCCACGCAGGCCGCGCTGTGC
CGCCTGCTGGCGCGTGCGGCGGGCTCGACCGGCATGGCCGGCGGCCAGGCGATCGATCTGGCCAGCGTCGGCCTGCGGCT
CACCGAAGGGCAGTTGCGCCAGATGCACCGCCTCAAGACCGGCGCGCTGCTGCAGGCCAGCGTGCTGATGGGCGCCGTGT
GCGGCCAGGCCGCGCCTGCGGCCTATCGGGCGCTGTCCGACTATGGTGCGGCGCTGGGGCTGGCGTTCCAGGTGGTGGAT
GACATCCTCGACGTGGTGGCCGATTCGGCCACGCTGGGCAAGACGGCCGGCAAGGATGCCATCGCCGCCAAGCCCACCTA
TGTATCGCTGCTGGGCCTGGAACGGGCCCAGGCCCAGGCCCGGGAACTGCTGGCCGGCGCGCATGCGGCCCGGCTCCGCA
GCGACCTGCCCGACACCCGTGCGCTGGCCGCGCTGGCCGACATGGTACTGTCCCGCCCCTCTTGA

Upstream 100 bases:

>100_bases
GCGGCGCCAGTTTGCTGTCCTTTTGCCGCCAGCGTCTGGATGCGGTGCAGGAGCAGATCAAGGTGCTCGATGATGGCCCG
CTGCAACCTTGGGTCCAGCA

Downstream 100 bases:

>100_bases
CGTTCTTCTCGACGCCCCTGTCTGACCGGCCTCTGGTGCTGATATTTCCTGCACCGGTAGCTATCAAAAAATAGTAAATG
CCAAGCACATCCTTTCCCCT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSAASTLSAAAAPLDLGGWQQNHLAQVEQALSQWVGHGAPAGLGEAMRYAVLDGGKRLRPLLVLAAYQAVCSGQPAPCAW
HDAAALRAACAVELIHAYSLVHDDLPCMDNDVLRRGKPTAHVRFGPARALLAGDALQAFAFELLTPEDMPIPAATQAALC
RLLARAAGSTGMAGGQAIDLASVGLRLTEGQLRQMHRLKTGALLQASVLMGAVCGQAAPAAYRALSDYGAALGLAFQVVD
DILDVVADSATLGKTAGKDAIAAKPTYVSLLGLERAQAQARELLAGAHAARLRSDLPDTRALAALADMVLSRPS

Sequences:

>Translated_314_residues
MSAASTLSAAAAPLDLGGWQQNHLAQVEQALSQWVGHGAPAGLGEAMRYAVLDGGKRLRPLLVLAAYQAVCSGQPAPCAW
HDAAALRAACAVELIHAYSLVHDDLPCMDNDVLRRGKPTAHVRFGPARALLAGDALQAFAFELLTPEDMPIPAATQAALC
RLLARAAGSTGMAGGQAIDLASVGLRLTEGQLRQMHRLKTGALLQASVLMGAVCGQAAPAAYRALSDYGAALGLAFQVVD
DILDVVADSATLGKTAGKDAIAAKPTYVSLLGLERAQAQARELLAGAHAARLRSDLPDTRALAALADMVLSRPS
>Mature_313_residues
SAASTLSAAAAPLDLGGWQQNHLAQVEQALSQWVGHGAPAGLGEAMRYAVLDGGKRLRPLLVLAAYQAVCSGQPAPCAWH
DAAALRAACAVELIHAYSLVHDDLPCMDNDVLRRGKPTAHVRFGPARALLAGDALQAFAFELLTPEDMPIPAATQAALCR
LLARAAGSTGMAGGQAIDLASVGLRLTEGQLRQMHRLKTGALLQASVLMGAVCGQAAPAAYRALSDYGAALGLAFQVVDD
ILDVVADSATLGKTAGKDAIAAKPTYVSLLGLERAQAQARELLAGAHAARLRSDLPDTRALAALADMVLSRPS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=300, Percent_Identity=46, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1789578, Length=219, Percent_Identity=32.8767123287671, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=241, Percent_Identity=26.5560165975104, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651612, Length=217, Percent_Identity=29.4930875576037, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32418; Mature: 32286

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAASTLSAAAAPLDLGGWQQNHLAQVEQALSQWVGHGAPAGLGEAMRYAVLDGGKRLRP
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHH
LLVLAAYQAVCSGQPAPCAWHDAAALRAACAVELIHAYSLVHDDLPCMDNDVLRRGKPTA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCE
HVRFGPARALLAGDALQAFAFELLTPEDMPIPAATQAALCRLLARAAGSTGMAGGQAIDL
EEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
ASVGLRLTEGQLRQMHRLKTGALLQASVLMGAVCGQAAPAAYRALSDYGAALGLAFQVVD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
DILDVVADSATLGKTAGKDAIAAKPTYVSLLGLERAQAQARELLAGAHAARLRSDLPDTR
HHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALAALADMVLSRPS
HHHHHHHHHHCCCC
>Mature Secondary Structure 
SAASTLSAAAAPLDLGGWQQNHLAQVEQALSQWVGHGAPAGLGEAMRYAVLDGGKRLRP
CCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHH
LLVLAAYQAVCSGQPAPCAWHDAAALRAACAVELIHAYSLVHDDLPCMDNDVLRRGKPTA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCE
HVRFGPARALLAGDALQAFAFELLTPEDMPIPAATQAALCRLLARAAGSTGMAGGQAIDL
EEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
ASVGLRLTEGQLRQMHRLKTGALLQASVLMGAVCGQAAPAAYRALSDYGAALGLAFQVVD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
DILDVVADSATLGKTAGKDAIAAKPTYVSLLGLERAQAQARELLAGAHAARLRSDLPDTR
HHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALAALADMVLSRPS
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]