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The map label for this gene is dxs

Identifier: 121610224

GI number: 121610224

Start: 3661499

End: 3663394

Strand: Direct

Name: dxs

Synonym: Veis_3283

Alternate gene names: 121610224

Gene position: 3661499-3663394 (Clockwise)

Preceding gene: 121610223

Following gene: 121610225

Centisome position: 65.77

GC content: 67.25

Gene sequence:

>1896_bases
ATGCCAAGCACATCCTTTCCCCTGCTGGAAACCATCGACGACCCGGCGCAACTGCGCCAGCTCGCGCGCGCGCAGCTCAA
GGTGCTGGCTGCGGAGCTGCGCGGCTTCGTGCTGGAGAGCGTCTCGCGCACCGGCGGCCACCTGAGCTCCAACCTGGGCA
CGGTGGAACTGACGGTGGCGCTGCACCATGTATTCCAGACGCCGCATGACCGCCTGGTATGGGACGTGGGCCACCAGACC
TATGCGCACAAGATACTGACCGGCCGGCGTGAGCGCATGCACACGCTGCGCCAGCAAGGCGGCATCTCGGGCTTTCCGCA
GCGCGGCGAGAGCGTGTACGACACCTTCGGCACGGCGCATTCGAGCACCAGCATCTCGGCCGCGCTGGGCATGGCGCTGG
CGGCCAAGCGCAAGGGCGAGAGCCGCCACACCGTGGCCATCATCGGCGACGGCGCGATGAGCGCCGGCATGGCCTTCGAG
GCGCTGAACAACGCCGGCGTGGCCGACTGCAACCTGCTGGTGGTGCTCAACGACAACGACATGAGCATCAGCCCCCCGGT
GGGCGCGCTCAACCGCTACCTGGCCCAGCTCATGAGCGGGCGGTTCTACGCAGCGGCCAAGAACATGGGCAAGACCGTGC
TGCGGCCCATGCCCCCGTTGCTGGAATTTGCCAAGCGCTTCGAGCAACAGGCCAAGGGCCTGGTCGTGCCCGCCACATTG
TTCGAGAAATTCGGCTTCAACTACATCGGGCCGATCGACGGGCATGACCTCGATTCACTGATCCCCACGCTGGACAACAT
CAAGGGCCTCCAAGGCCCGCAATTCCTGCATGTGGTGACCAAAAAAGGCCAGGGCTACAAGCTCGCCGAGGCCGACCCGG
TGGCCTACCACGGCCCGGCCCGGTTCGACCCCGCCGTGGGCCTGGTCAAAAGCAGCACCGCGCCCCGGCTGACCTTCACC
CAGGTGTTTGGCCAGTGGCTGTGCGACATGGCCGCGCACGATGAACGCCTGGTGGGCATCACGCCCGCGATGCGCGAAGG
CTCGGGCATGGTCGAATTCGAGCAGCGCTTTCCCGACCGGTACTACGACGTGGGCATCGCCGAGCAGCATGCCGTGACCT
TTGCCGCCGGCATGGCCTGCGAGGGCGCCAAGCCCGTGGTGGCGATCTACTCGACCTTCCTGCAGCGCGGCTACGACCAA
CTGATCCACGACGTGGCCCTGCAAAACCTGCCGGTGGTATTTGCGCTCGACCGCGCCGGCCTGGTCGGGGCCGATGGCGC
CACCCATGCCGGCGCCTACGACATCGCGTTCCTGCGCTGCATTCCGAACATGGGCCTGGCCTGCCCCGCCGACGAGCGCG
AATGCCGCCAACTGCTGAGCAGCGCCTATGCCCAAAACCACCCCGTGGCCGTGCGCTACCCGCGCGGCAGTGGTGCCGGA
GTGGCGCCACTGGCCGGGCTGGACGGCCTGCCCTTTGGCAAAGGCGAAATCCGCCGCGAACGCCAGCGCCAAGACAGCAA
CGCACCGCGCATTGCCATCCTGGCGTTCGGCAGCTTGCTGTATCCGGCGCTGGAAGCGGCCGATGCGCTCGATGCCACCG
TGGTCAACATGCGCTGGGCCAAGCCCCTCGATGACGCCTTGCTGCGCCAAGTGGCCGAAGGCCACGATGCCCTGGTCACG
CTGGAAGAAGGCGCCATCATGGGCGGCGCCGGCAGCGCAGTGACCGAAACGCTCAACGCCGCAGGCATCTTGCGCCCGGT
GCTGCAACTGGGCCTGGCGGACATCTTCATCGAACATGGCGACCCGGCCAAACTGCTGGCCATGCAGGGACTGAACGCAG
CCGGCATCCGCGCGGCAATTGCTGCGCGCTTTCCGGCCATCGACGTGGCCCGATGA

Upstream 100 bases:

>100_bases
TGGTACTGTCCCGCCCCTCTTGACGTTCTTCTCGACGCCCCTGTCTGACCGGCCTCTGGTGCTGATATTTCCTGCACCGG
TAGCTATCAAAAAATAGTAA

Downstream 100 bases:

>100_bases
TGCGGCCCTGGTGGCGGACGATACCGAGGGGGCCCCGATGGCACGGGAAAACCCGCAAAAAGCGCCACCGGCATGTTTCT
ACAATGGCCCCGGGGCCGGA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MPSTSFPLLETIDDPAQLRQLARAQLKVLAAELRGFVLESVSRTGGHLSSNLGTVELTVALHHVFQTPHDRLVWDVGHQT
YAHKILTGRRERMHTLRQQGGISGFPQRGESVYDTFGTAHSSTSISAALGMALAAKRKGESRHTVAIIGDGAMSAGMAFE
ALNNAGVADCNLLVVLNDNDMSISPPVGALNRYLAQLMSGRFYAAAKNMGKTVLRPMPPLLEFAKRFEQQAKGLVVPATL
FEKFGFNYIGPIDGHDLDSLIPTLDNIKGLQGPQFLHVVTKKGQGYKLAEADPVAYHGPARFDPAVGLVKSSTAPRLTFT
QVFGQWLCDMAAHDERLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRGYDQ
LIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAFLRCIPNMGLACPADERECRQLLSSAYAQNHPVAVRYPRGSGAG
VAPLAGLDGLPFGKGEIRRERQRQDSNAPRIAILAFGSLLYPALEAADALDATVVNMRWAKPLDDALLRQVAEGHDALVT
LEEGAIMGGAGSAVTETLNAAGILRPVLQLGLADIFIEHGDPAKLLAMQGLNAAGIRAAIAARFPAIDVAR

Sequences:

>Translated_631_residues
MPSTSFPLLETIDDPAQLRQLARAQLKVLAAELRGFVLESVSRTGGHLSSNLGTVELTVALHHVFQTPHDRLVWDVGHQT
YAHKILTGRRERMHTLRQQGGISGFPQRGESVYDTFGTAHSSTSISAALGMALAAKRKGESRHTVAIIGDGAMSAGMAFE
ALNNAGVADCNLLVVLNDNDMSISPPVGALNRYLAQLMSGRFYAAAKNMGKTVLRPMPPLLEFAKRFEQQAKGLVVPATL
FEKFGFNYIGPIDGHDLDSLIPTLDNIKGLQGPQFLHVVTKKGQGYKLAEADPVAYHGPARFDPAVGLVKSSTAPRLTFT
QVFGQWLCDMAAHDERLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRGYDQ
LIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAFLRCIPNMGLACPADERECRQLLSSAYAQNHPVAVRYPRGSGAG
VAPLAGLDGLPFGKGEIRRERQRQDSNAPRIAILAFGSLLYPALEAADALDATVVNMRWAKPLDDALLRQVAEGHDALVT
LEEGAIMGGAGSAVTETLNAAGILRPVLQLGLADIFIEHGDPAKLLAMQGLNAAGIRAAIAARFPAIDVAR
>Mature_630_residues
PSTSFPLLETIDDPAQLRQLARAQLKVLAAELRGFVLESVSRTGGHLSSNLGTVELTVALHHVFQTPHDRLVWDVGHQTY
AHKILTGRRERMHTLRQQGGISGFPQRGESVYDTFGTAHSSTSISAALGMALAAKRKGESRHTVAIIGDGAMSAGMAFEA
LNNAGVADCNLLVVLNDNDMSISPPVGALNRYLAQLMSGRFYAAAKNMGKTVLRPMPPLLEFAKRFEQQAKGLVVPATLF
EKFGFNYIGPIDGHDLDSLIPTLDNIKGLQGPQFLHVVTKKGQGYKLAEADPVAYHGPARFDPAVGLVKSSTAPRLTFTQ
VFGQWLCDMAAHDERLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRGYDQL
IHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAFLRCIPNMGLACPADERECRQLLSSAYAQNHPVAVRYPRGSGAGV
APLAGLDGLPFGKGEIRRERQRQDSNAPRIAILAFGSLLYPALEAADALDATVVNMRWAKPLDDALLRQVAEGHDALVTL
EEGAIMGGAGSAVTETLNAAGILRPVLQLGLADIFIEHGDPAKLLAMQGLNAAGIRAAIAARFPAIDVAR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=676, Percent_Identity=22.0414201183432, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4507521, Length=676, Percent_Identity=22.0414201183432, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI225637459, Length=434, Percent_Identity=25.1152073732719, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI225637463, Length=434, Percent_Identity=25.1152073732719, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI225637461, Length=434, Percent_Identity=25.1152073732719, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786622, Length=619, Percent_Identity=56.2197092084006, Blast_Score=726, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=426, Percent_Identity=25.3521126760563, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24666278, Length=645, Percent_Identity=25.8914728682171, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45551847, Length=640, Percent_Identity=24.21875, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550715, Length=640, Percent_Identity=24.21875, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645119, Length=597, Percent_Identity=23.9530988274707, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_VEREI (A1WN06)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_998031.1
- ProteinModelPortal:   A1WN06
- SMR:   A1WN06
- STRING:   A1WN06
- GeneID:   4694154
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_3283
- NMPDR:   fig|391735.5.peg.3044
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   A1WN06
- ProtClustDB:   PRK05444
- BioCyc:   VEIS391735:VEIS_3283-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67577; Mature: 67446

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTSFPLLETIDDPAQLRQLARAQLKVLAAELRGFVLESVSRTGGHLSSNLGTVELTVA
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHH
LHHVFQTPHDRLVWDVGHQTYAHKILTGRRERMHTLRQQGGISGFPQRGESVYDTFGTAH
HHHHHHCCCHHEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCC
SSTSISAALGMALAAKRKGESRHTVAIIGDGAMSAGMAFEALNNAGVADCNLLVVLNDND
CCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCC
MSISPPVGALNRYLAQLMSGRFYAAAKNMGKTVLRPMPPLLEFAKRFEQQAKGLVVPATL
CCCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCEEEHHHH
FEKFGFNYIGPIDGHDLDSLIPTLDNIKGLQGPQFLHVVTKKGQGYKLAEADPVAYHGPA
HHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEECCCCCCEECCCC
RFDPAVGLVKSSTAPRLTFTQVFGQWLCDMAAHDERLVGITPAMREGSGMVEFEQRFPDR
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCHHHHHCCHH
YYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDRAG
HHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
LVGADGATHAGAYDIAFLRCIPNMGLACPADERECRQLLSSAYAQNHPVAVRYPRGSGAG
EECCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
VAPLAGLDGLPFGKGEIRRERQRQDSNAPRIAILAFGSLLYPALEAADALDATVVNMRWA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHEEEECC
KPLDDALLRQVAEGHDALVTLEEGAIMGGAGSAVTETLNAAGILRPVLQLGLADIFIEHG
CCHHHHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECC
DPAKLLAMQGLNAAGIRAAIAARFPAIDVAR
CCHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PSTSFPLLETIDDPAQLRQLARAQLKVLAAELRGFVLESVSRTGGHLSSNLGTVELTVA
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHH
LHHVFQTPHDRLVWDVGHQTYAHKILTGRRERMHTLRQQGGISGFPQRGESVYDTFGTAH
HHHHHHCCCHHEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCC
SSTSISAALGMALAAKRKGESRHTVAIIGDGAMSAGMAFEALNNAGVADCNLLVVLNDND
CCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCC
MSISPPVGALNRYLAQLMSGRFYAAAKNMGKTVLRPMPPLLEFAKRFEQQAKGLVVPATL
CCCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCEEEHHHH
FEKFGFNYIGPIDGHDLDSLIPTLDNIKGLQGPQFLHVVTKKGQGYKLAEADPVAYHGPA
HHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEECCCCCCEECCCC
RFDPAVGLVKSSTAPRLTFTQVFGQWLCDMAAHDERLVGITPAMREGSGMVEFEQRFPDR
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCHHHHHCCHH
YYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDRAG
HHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
LVGADGATHAGAYDIAFLRCIPNMGLACPADERECRQLLSSAYAQNHPVAVRYPRGSGAG
EECCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
VAPLAGLDGLPFGKGEIRRERQRQDSNAPRIAILAFGSLLYPALEAADALDATVVNMRWA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHEEEECC
KPLDDALLRQVAEGHDALVTLEEGAIMGGAGSAVTETLNAAGILRPVLQLGLADIFIEHG
CCHHHHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECC
DPAKLLAMQGLNAAGIRAAIAARFPAIDVAR
CCHHHHHHCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA