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The map label for this gene is luxQ [H]

Identifier: 120612997

GI number: 120612997

Start: 4846708

End: 4848585

Strand: Reverse

Name: luxQ [H]

Synonym: Aave_4361

Alternate gene names: 120612997

Gene position: 4848585-4846708 (Counterclockwise)

Preceding gene: 120612998

Following gene: 120612996

Centisome position: 90.58

GC content: 70.66

Gene sequence:

>1878_bases
ATGCCCATCGCTCCTGACAGCCTCTATCCCGACGCATGGCGCAGAGCGGACGGCGACGATGCCCACGCATCCGGTGCCGG
ACTCGATCTGGCGGTGCGGCGCCGGCTGCTGGACTCGCTCGCATCGCGGGGAGGAACTTCGGAAATTCCCGCCCTCGTGA
TCCCCGGTGTGTTGACCTGGCTGTACGCGCGCCATGGGACGCCTGCCGCCCACATGCTGGCGTGGTGGGGGAGCTTCCTG
GTATTCGTCTGCCTGCTCCTGTTCCTGCTGCGGCGTTTCCGCCGCGATGCGGTACTGCCCGACCAGGTGGTGGTGCCGCG
CTGGGAGCGGACCTTCCAGGCGATGGCCGCGTTGGACGGCGCGTTCTGGGCCGTGCCCATCGTGCTCACGCACGGCGCGC
CGCTGGAGTTCCGGCTGCTGACCTACCTCGTCATCTGCGCGGTACTGGCCGTGGGAACCACCTTCCTGGCGCCGCACCCC
CGGGTGTTCTTTCCATTCTTCGCGGCGATCTACGGGCCCACTCTGCTGGCCTCGGCCTGGTACTTTCCGGACCGCTGGCA
GGCCATGCTGCCGTTGACGGTGCTGTATGGCGGGGTGGTCTTGCGGCATGCGTGGGGTTCGCGGCGCTTCGTCGTGCAGC
AGGTGGAGATGGAGCGCCAGCGCTTGCAGCTGGCCCAGCGCTACCTTGCGGCGAAGGAGGAGGCCGAGCGCGCGCTGGAG
GAGAAGAACCGCTTCCTGTCCACGGCCAGCCATGACCTGCGCCAGCCGCTGCATGCGATGGGGCTGCTGGTGGAGTCGGC
GCAGCAGCGCAATGCCGACGCGGGGCTGGTGCCGGTGCTGGAGGGGATCCAGGACTGCGCCCGCTCGCTGACGTTCCTTT
TCAACGCGCTGCTGGACCTGTCCCGGCTGGAGTCCGGCGCCTATGCCGTCGTCCAGGAGGATGTCCCTCTCGCGGAGGTA
CTGCACGACGTGTCCACGGTGTTCGGCCCGGATGCGCGCCATCGCGGCCTGCGGCTGAAGGTCTATCTGCCGCGGCGCCG
GCCGGCCGTCGTGCGTGCCGATGCGGCGCTGCTGCGGCAGATGGTTTTCAACCTGGTGCAGAACGCGCTGCGCTATACGC
GCGTGGGAGGCGTGCTGATCGGTGCGCGGATGCGGCGCGGGGTCTGGCGCATCGAGGTCTGGGACACCGGCCCGGGCGTG
CCGCAGGAAGACCGGCACCGCATCTACGCCCCCTTCTACCGGAGCGAGGCCCGCTGGACCCAGGAAGTCGCGGGCCACGG
GCTGGGACTGTCGGTGGTGGCCCGGTCGGCGCGGTTGATCGATGCGGAGTCCGGTTTCGAATCCCGGCCGGGACGCGGTT
CGTGCTTCTGGCTGGTGGTGGAGGCGGCGAAGGATGGGCCGGGGAGCTCCGATGCTCCGCCGGGGCCGGCGGTGGTTCCG
GTCCCGCCGTGGCAGCGGAGACTGGGCTCGCTGTCGGGCCGTTGCCTGCTGGTCGAGGACGATCCGCAGGTGGCGCGCGC
GGTGGCAGAGCTGCTCCAGTCCTGGGGGCTGCGTGTCGCGACGGCTGCGACGGCGACGCAGGCCATGGCGCATGCGGAGT
CCGGCACGGCGCCTGACGTGGTGCTGTGCGATCAGCGCCTGGGCGGAGGTGAGAGCGGGTTCGACGTGCTGCGCGCCCTG
CTCGTACGGTTTCCCTCCGCGCGCGGAGCGCTGGTCAGCGGCGAATACGACGCCGCCCCGCTGGCGCAGGCCGAGGAGGA
CGGCTATCTCGTCTTTCGCAAGCCGCTCGCGCCGGAGGCGCTGCACTCGGTGCTGGCGCGTTGGCTGGACGAGAAGTCCC
GAGGCCCCGCCGCTGGCCGCGGATGTGCTGCCGGGTAA

Upstream 100 bases:

>100_bases
CGCCTGCACGAGCGCAGCCGCTTCGTGCGCGAGGGCGGGCGCTGGTTCTATGTGAATGGCGAGTTTCCGCGCGGCTGATA
CCGCCCGCCGATGCCAACCG

Downstream 100 bases:

>100_bases
AAAAAATCCCTCCGGTGGGGTAGGGGTGCGTCCCTGTTCTTCCGACAATGCCTTGCGTCCGCGTTTTGCGGCGCTCTCAC
GGCAGGCCGTGCCGGTCGCT

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MPIAPDSLYPDAWRRADGDDAHASGAGLDLAVRRRLLDSLASRGGTSEIPALVIPGVLTWLYARHGTPAAHMLAWWGSFL
VFVCLLLFLLRRFRRDAVLPDQVVVPRWERTFQAMAALDGAFWAVPIVLTHGAPLEFRLLTYLVICAVLAVGTTFLAPHP
RVFFPFFAAIYGPTLLASAWYFPDRWQAMLPLTVLYGGVVLRHAWGSRRFVVQQVEMERQRLQLAQRYLAAKEEAERALE
EKNRFLSTASHDLRQPLHAMGLLVESAQQRNADAGLVPVLEGIQDCARSLTFLFNALLDLSRLESGAYAVVQEDVPLAEV
LHDVSTVFGPDARHRGLRLKVYLPRRRPAVVRADAALLRQMVFNLVQNALRYTRVGGVLIGARMRRGVWRIEVWDTGPGV
PQEDRHRIYAPFYRSEARWTQEVAGHGLGLSVVARSARLIDAESGFESRPGRGSCFWLVVEAAKDGPGSSDAPPGPAVVP
VPPWQRRLGSLSGRCLLVEDDPQVARAVAELLQSWGLRVATAATATQAMAHAESGTAPDVVLCDQRLGGGESGFDVLRAL
LVRFPSARGALVSGEYDAAPLAQAEEDGYLVFRKPLAPEALHSVLARWLDEKSRGPAAGRGCAAG

Sequences:

>Translated_625_residues
MPIAPDSLYPDAWRRADGDDAHASGAGLDLAVRRRLLDSLASRGGTSEIPALVIPGVLTWLYARHGTPAAHMLAWWGSFL
VFVCLLLFLLRRFRRDAVLPDQVVVPRWERTFQAMAALDGAFWAVPIVLTHGAPLEFRLLTYLVICAVLAVGTTFLAPHP
RVFFPFFAAIYGPTLLASAWYFPDRWQAMLPLTVLYGGVVLRHAWGSRRFVVQQVEMERQRLQLAQRYLAAKEEAERALE
EKNRFLSTASHDLRQPLHAMGLLVESAQQRNADAGLVPVLEGIQDCARSLTFLFNALLDLSRLESGAYAVVQEDVPLAEV
LHDVSTVFGPDARHRGLRLKVYLPRRRPAVVRADAALLRQMVFNLVQNALRYTRVGGVLIGARMRRGVWRIEVWDTGPGV
PQEDRHRIYAPFYRSEARWTQEVAGHGLGLSVVARSARLIDAESGFESRPGRGSCFWLVVEAAKDGPGSSDAPPGPAVVP
VPPWQRRLGSLSGRCLLVEDDPQVARAVAELLQSWGLRVATAATATQAMAHAESGTAPDVVLCDQRLGGGESGFDVLRAL
LVRFPSARGALVSGEYDAAPLAQAEEDGYLVFRKPLAPEALHSVLARWLDEKSRGPAAGRGCAAG
>Mature_624_residues
PIAPDSLYPDAWRRADGDDAHASGAGLDLAVRRRLLDSLASRGGTSEIPALVIPGVLTWLYARHGTPAAHMLAWWGSFLV
FVCLLLFLLRRFRRDAVLPDQVVVPRWERTFQAMAALDGAFWAVPIVLTHGAPLEFRLLTYLVICAVLAVGTTFLAPHPR
VFFPFFAAIYGPTLLASAWYFPDRWQAMLPLTVLYGGVVLRHAWGSRRFVVQQVEMERQRLQLAQRYLAAKEEAERALEE
KNRFLSTASHDLRQPLHAMGLLVESAQQRNADAGLVPVLEGIQDCARSLTFLFNALLDLSRLESGAYAVVQEDVPLAEVL
HDVSTVFGPDARHRGLRLKVYLPRRRPAVVRADAALLRQMVFNLVQNALRYTRVGGVLIGARMRRGVWRIEVWDTGPGVP
QEDRHRIYAPFYRSEARWTQEVAGHGLGLSVVARSARLIDAESGFESRPGRGSCFWLVVEAAKDGPGSSDAPPGPAVVPV
PPWQRRLGSLSGRCLLVEDDPQVARAVAELLQSWGLRVATAATATQAMAHAESGTAPDVVLCDQRLGGGESGFDVLRALL
VRFPSARGALVSGEYDAAPLAQAEEDGYLVFRKPLAPEALHSVLARWLDEKSRGPAAGRGCAAG

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=397, Percent_Identity=28.463476070529, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI87081816, Length=352, Percent_Identity=28.6931818181818, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1789149, Length=270, Percent_Identity=28.5185185185185, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI145693157, Length=336, Percent_Identity=24.4047619047619, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1788713, Length=343, Percent_Identity=24.198250728863, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=30.7359307359307, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790346, Length=198, Percent_Identity=32.8282828282828, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=28.6885245901639, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=27.0386266094421, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=25.7510729613734, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68572; Mature: 68440

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIAPDSLYPDAWRRADGDDAHASGAGLDLAVRRRLLDSLASRGGTSEIPALVIPGVLTW
CCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LYARHGTPAAHMLAWWGSFLVFVCLLLFLLRRFRRDAVLPDQVVVPRWERTFQAMAALDG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC
AFWAVPIVLTHGAPLEFRLLTYLVICAVLAVGTTFLAPHPRVFFPFFAAIYGPTLLASAW
HHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
YFPDRWQAMLPLTVLYGGVVLRHAWGSRRFVVQQVEMERQRLQLAQRYLAAKEEAERALE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKNRFLSTASHDLRQPLHAMGLLVESAQQRNADAGLVPVLEGIQDCARSLTFLFNALLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRLESGAYAVVQEDVPLAEVLHDVSTVFGPDARHRGLRLKVYLPRRRPAVVRADAALLRQ
HHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
MVFNLVQNALRYTRVGGVLIGARMRRGVWRIEVWDTGPGVPQEDRHRIYAPFYRSEARWT
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCEECCHHHHHHHHH
QEVAGHGLGLSVVARSARLIDAESGFESRPGRGSCFWLVVEAAKDGPGSSDAPPGPAVVP
HHHHCCCCCHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEC
VPPWQRRLGSLSGRCLLVEDDPQVARAVAELLQSWGLRVATAATATQAMAHAESGTAPDV
CCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCCE
VLCDQRLGGGESGFDVLRALLVRFPSARGALVSGEYDAAPLAQAEEDGYLVFRKPLAPEA
EEECCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCEEEEECCCCHHH
LHSVLARWLDEKSRGPAAGRGCAAG
HHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PIAPDSLYPDAWRRADGDDAHASGAGLDLAVRRRLLDSLASRGGTSEIPALVIPGVLTW
CCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH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HHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA