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The map label for this gene is degS [H]

Identifier: 120612866

GI number: 120612866

Start: 4686650

End: 4688086

Strand: Reverse

Name: degS [H]

Synonym: Aave_4230

Alternate gene names: 120612866

Gene position: 4688086-4686650 (Counterclockwise)

Preceding gene: 120612871

Following gene: 120612865

Centisome position: 87.58

GC content: 73.76

Gene sequence:

>1437_bases
ATGGGAACAGGCAAGGACGTATTTCGCGGAGCCCCGCCGGACGGCGCGTCCGCGGCCGGCGCGGCGGACCCCGCGGCCCG
CCTGCGCACGAAGATCGTGGCGCTGGCGGTCGTGCCGCTGCTCGTCACCCTGGCGCTGGTGACGGCCCTGGTGCGCCACC
AGGCGCAGGACCTCGCGCGGCGCGAGCGCGCCCTGGTGGAGCAGTCGTACCTGCAGCAGCGCCGCAGCGAGCTGCGCAGC
TACGTGGACCTGGCGGTGAGCACCGTGCGGCCGCTCTACGAGGCGGACGGCGACGACCCGAAGGCGCGGGAAGAGGCGAT
GCGCCGCCTGGCCGCGCTGGATTACGGCAGCGACGGCTACTTCTTCGTCTACGACATGCAGGGCCGCTCCCTCATGCACT
CGCGCCAGCCGGAACTGGTGGGCAGGATGCTGTGGGACCTGCGCGATCCCCAGGGGCGGCCGACCATCCAGCAGCTCATC
GCGCAGGCGCAGGCCGGCGGCGGCTTCGTGGAGTATTCCTGGCCCAAGCCTTCCCTCGGCGGGCAGCTCGCGCCGAAACT
GGGCTACGTGATCGCCCTGCCGCACTGGAACTGGATGGTGGGCACGGGGCTGTACCTGGACGACATCGAGGCCACGCAGG
CCGGCCTGGAGCGCCAGGTGGGCTCCAACGTGGGCACCACGATGTGGTGGATCGCGGGGTTCGCCGCCCTGGGCTTCGCG
GCGATCAGCGCCTGCGGGCTGCTGCTCAACCTCAGCGAGCACCGCCTGTCGGAGGCCCGCCTGCGCCTGCTCGCGCGCCG
TGTGGTGCAGTCGCAGGAGGAGGAGCGCGGCCACCTGGCGCGCGAACTGCACGACGGCACCAGCCAGACCCTGGTCTCCG
CCAAGCTGCTCATCGAGTCGGCGGTGGAGGAGATCGAGCGCGAGCGCCCGGCGCCGGCCACCCTCGGCACCGCGCTCCAG
CACCTCAACGAGGCCCTGGGCGAGGTGCGGCGCCTGTCGCACGAGCTGCGCCCGGCGCTGCTGGACACCCTGGGCCTGCC
CGCCGCGCTGGAGCACCTGGCCCGCGCCTTCGGCGAACATGGCCCGGTGGCGGCCTCCGCCGACGTGGCCCAGCCGCCGG
GTCCGCTGCCGCAGGACGTCACCACCGCGCTGTTCCGCGTCGCCCAGGAGGCGCTCACCAATGTGCGCAAGCATGCGCAG
GCGCGGCAGGTGCACGTGACGCTGGAATGCGTGGGCGGCGGCGTGCAGCTGGAGGTGCGCGACGACGGGCGGGGCTTCGA
TCCCGCGGCGCTGCAGCACGATCCGCGGCGCGGCATCGGCCTGCGCAACATGCACGAGCGCATGGCGGCCATCGGCGGCC
GGCTGCAGGTGCGTTCGGGCGCGGGCGGCACGCGCGTGGTGGCCGAGGTGCCCGCGGATAGGATGGAGCCCGCATGA

Upstream 100 bases:

>100_bases
CCGCTTCCGCTCGGCGCCGCCGTGCGGCGGCGCCCGTTCAAGGGGCGGGGGACCGCCGATTTTACGGCGGGAACGCATTT
CCGGGACGGATGGAAGGCGC

Downstream 100 bases:

>100_bases
CCGCTGCTGCCATCGCTCCGCTGGAGCGCCCCGTCCGCCTGTTCCTCGTCGATGACCATGCCCTGGTGCGCGACGGCCTG
CGCGCGCGCCTGGGCAGCCT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MGTGKDVFRGAPPDGASAAGAADPAARLRTKIVALAVVPLLVTLALVTALVRHQAQDLARRERALVEQSYLQQRRSELRS
YVDLAVSTVRPLYEADGDDPKAREEAMRRLAALDYGSDGYFFVYDMQGRSLMHSRQPELVGRMLWDLRDPQGRPTIQQLI
AQAQAGGGFVEYSWPKPSLGGQLAPKLGYVIALPHWNWMVGTGLYLDDIEATQAGLERQVGSNVGTTMWWIAGFAALGFA
AISACGLLLNLSEHRLSEARLRLLARRVVQSQEEERGHLARELHDGTSQTLVSAKLLIESAVEEIERERPAPATLGTALQ
HLNEALGEVRRLSHELRPALLDTLGLPAALEHLARAFGEHGPVAASADVAQPPGPLPQDVTTALFRVAQEALTNVRKHAQ
ARQVHVTLECVGGGVQLEVRDDGRGFDPAALQHDPRRGIGLRNMHERMAAIGGRLQVRSGAGGTRVVAEVPADRMEPA

Sequences:

>Translated_478_residues
MGTGKDVFRGAPPDGASAAGAADPAARLRTKIVALAVVPLLVTLALVTALVRHQAQDLARRERALVEQSYLQQRRSELRS
YVDLAVSTVRPLYEADGDDPKAREEAMRRLAALDYGSDGYFFVYDMQGRSLMHSRQPELVGRMLWDLRDPQGRPTIQQLI
AQAQAGGGFVEYSWPKPSLGGQLAPKLGYVIALPHWNWMVGTGLYLDDIEATQAGLERQVGSNVGTTMWWIAGFAALGFA
AISACGLLLNLSEHRLSEARLRLLARRVVQSQEEERGHLARELHDGTSQTLVSAKLLIESAVEEIERERPAPATLGTALQ
HLNEALGEVRRLSHELRPALLDTLGLPAALEHLARAFGEHGPVAASADVAQPPGPLPQDVTTALFRVAQEALTNVRKHAQ
ARQVHVTLECVGGGVQLEVRDDGRGFDPAALQHDPRRGIGLRNMHERMAAIGGRLQVRSGAGGTRVVAEVPADRMEPA
>Mature_477_residues
GTGKDVFRGAPPDGASAAGAADPAARLRTKIVALAVVPLLVTLALVTALVRHQAQDLARRERALVEQSYLQQRRSELRSY
VDLAVSTVRPLYEADGDDPKAREEAMRRLAALDYGSDGYFFVYDMQGRSLMHSRQPELVGRMLWDLRDPQGRPTIQQLIA
QAQAGGGFVEYSWPKPSLGGQLAPKLGYVIALPHWNWMVGTGLYLDDIEATQAGLERQVGSNVGTTMWWIAGFAALGFAA
ISACGLLLNLSEHRLSEARLRLLARRVVQSQEEERGHLARELHDGTSQTLVSAKLLIESAVEEIERERPAPATLGTALQH
LNEALGEVRRLSHELRPALLDTLGLPAALEHLARAFGEHGPVAASADVAQPPGPLPQDVTTALFRVAQEALTNVRKHAQA
RQVHVTLECVGGGVQLEVRDDGRGFDPAALQHDPRRGIGLRNMHERMAAIGGRLQVRSGAGGTRVVAEVPADRMEPA

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=201, Percent_Identity=31.3432835820896, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082311, Length=237, Percent_Identity=32.4894514767932, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788812, Length=200, Percent_Identity=29, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51866; Mature: 51735

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTGKDVFRGAPPDGASAAGAADPAARLRTKIVALAVVPLLVTLALVTALVRHQAQDLAR
CCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RERALVEQSYLQQRRSELRSYVDLAVSTVRPLYEADGDDPKAREEAMRRLAALDYGSDGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCE
FFVYDMQGRSLMHSRQPELVGRMLWDLRDPQGRPTIQQLIAQAQAGGGFVEYSWPKPSLG
EEEEECCCCHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCC
GQLAPKLGYVIALPHWNWMVGTGLYLDDIEATQAGLERQVGSNVGTTMWWIAGFAALGFA
CCCCCCCCEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AISACGLLLNLSEHRLSEARLRLLARRVVQSQEEERGHLARELHDGTSQTLVSAKLLIES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AVEEIERERPAPATLGTALQHLNEALGEVRRLSHELRPALLDTLGLPAALEHLARAFGEH
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
GPVAASADVAQPPGPLPQDVTTALFRVAQEALTNVRKHAQARQVHVTLECVGGGVQLEVR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEC
DDGRGFDPAALQHDPRRGIGLRNMHERMAAIGGRLQVRSGAGGTRVVAEVPADRMEPA
CCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
GTGKDVFRGAPPDGASAAGAADPAARLRTKIVALAVVPLLVTLALVTALVRHQAQDLAR
CCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RERALVEQSYLQQRRSELRSYVDLAVSTVRPLYEADGDDPKAREEAMRRLAALDYGSDGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCE
FFVYDMQGRSLMHSRQPELVGRMLWDLRDPQGRPTIQQLIAQAQAGGGFVEYSWPKPSLG
EEEEECCCCHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCC
GQLAPKLGYVIALPHWNWMVGTGLYLDDIEATQAGLERQVGSNVGTTMWWIAGFAALGFA
CCCCCCCCEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AISACGLLLNLSEHRLSEARLRLLARRVVQSQEEERGHLARELHDGTSQTLVSAKLLIES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AVEEIERERPAPATLGTALQHLNEALGEVRRLSHELRPALLDTLGLPAALEHLARAFGEH
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
GPVAASADVAQPPGPLPQDVTTALFRVAQEALTNVRKHAQARQVHVTLECVGGGVQLEVR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEC
DDGRGFDPAALQHDPRRGIGLRNMHERMAAIGGRLQVRSGAGGTRVVAEVPADRMEPA
CCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]