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The map label for this gene is phhA [H]

Identifier: 120612829

GI number: 120612829

Start: 4645048

End: 4645926

Strand: Direct

Name: phhA [H]

Synonym: Aave_4193

Alternate gene names: 120612829

Gene position: 4645048-4645926 (Clockwise)

Preceding gene: 120612828

Following gene: 120612831

Centisome position: 86.78

GC content: 67.92

Gene sequence:

>879_bases
ATGGGCATTCCCGCGCATTGCATAACCAGGAGACATGCCATGGGACAAGCCCCCGTCGTTTACGGCCAATCCGACCGCCC
CCCGCGCGGCGACTATGCCCGCGCCGGCAGCGACTACACCTGCGCGCAGGACTATGCGGCCTACACGCCGCAGGACCACG
ACACCTACCGGCGCCTGTACGCCCGCCAGTCGGCGCTGCTGCCGGGCCGCGCGAGCGAGGCCTTCATCGCCGCCCTGCCC
TCGCTGGGCGCGAGCGACCGCATCCCGCGCTTCGACGAGATCAACGAGCGGCTGCAGCGCGCCACGGGCTGGGAGATCGT
GGGCGTCCCGGGCCTGATTCCCGAGGTGCCCTTTTTCACGCTGCTGGCGAACCGCAAGTTTCCGGTGACGGACTGGATCC
GCACGCCCGAGGAGTTCGACTACATCGTGGAGCCGGACATCTTCCACGACCTGTTCGGGCACGTGCCGCTGCTCTTCAAC
CCGGTGTTCGCCGACTATGTGCAGCGCTACGGCCAGGGGGGCCTGAAGGCGCACGGGCTGGGTGCCTGCGAGATGTTGTC
GCGCCTGTACTGGTACACGATCGAATTCGGCCTGATCCGCGAACGCGGTGCGCTGCGTGCCTACGGGGCGGGCATCCTCA
GCTCCTCCGGCGAACTGGAATATTCGGTGAACAGCCCCGAGCCGCAGCGCCTGCCGCTGCAGCTGGAACGCACCATGCGC
ACGCGCTACAAGATCGACACCTACCAGCAGACGTATTTCGTGATCGACAGCTTCGAGCAGCTGTTCGCGATGACGGAGCC
GGACTTCGGGCCGGTGTACGAGCGCCTGCGCGGGCAGGCCGAGTTCGCCGCGGACGAGCGCGAGGCCGTGGCGGCCTGA

Upstream 100 bases:

>100_bases
GAAACCTTCGGCCAGTTCGTGCGCGCGGAGCACGCGAAGTACGGCTTCCTGATCAAGGCCGCGAAGATCAAGATGGACTG
ACAGCGCGGGGCGCCCTGGC

Downstream 100 bases:

>100_bases
GGGGCGCCGGAGGACCGCGCAGGGCCGGGAAGGGCCGGCCTGCGTTGGAAGGCGCCCTGCCGGATGACTTCGTGCGCCGG
CAATACGTTTCGGGTGGCGC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MGIPAHCITRRHAMGQAPVVYGQSDRPPRGDYARAGSDYTCAQDYAAYTPQDHDTYRRLYARQSALLPGRASEAFIAALP
SLGASDRIPRFDEINERLQRATGWEIVGVPGLIPEVPFFTLLANRKFPVTDWIRTPEEFDYIVEPDIFHDLFGHVPLLFN
PVFADYVQRYGQGGLKAHGLGACEMLSRLYWYTIEFGLIRERGALRAYGAGILSSSGELEYSVNSPEPQRLPLQLERTMR
TRYKIDTYQQTYFVIDSFEQLFAMTEPDFGPVYERLRGQAEFAADEREAVAA

Sequences:

>Translated_292_residues
MGIPAHCITRRHAMGQAPVVYGQSDRPPRGDYARAGSDYTCAQDYAAYTPQDHDTYRRLYARQSALLPGRASEAFIAALP
SLGASDRIPRFDEINERLQRATGWEIVGVPGLIPEVPFFTLLANRKFPVTDWIRTPEEFDYIVEPDIFHDLFGHVPLLFN
PVFADYVQRYGQGGLKAHGLGACEMLSRLYWYTIEFGLIRERGALRAYGAGILSSSGELEYSVNSPEPQRLPLQLERTMR
TRYKIDTYQQTYFVIDSFEQLFAMTEPDFGPVYERLRGQAEFAADEREAVAA
>Mature_291_residues
GIPAHCITRRHAMGQAPVVYGQSDRPPRGDYARAGSDYTCAQDYAAYTPQDHDTYRRLYARQSALLPGRASEAFIAALPS
LGASDRIPRFDEINERLQRATGWEIVGVPGLIPEVPFFTLLANRKFPVTDWIRTPEEFDYIVEPDIFHDLFGHVPLLFNP
VFADYVQRYGQGGLKAHGLGACEMLSRLYWYTIEFGLIRERGALRAYGAGILSSSGELEYSVNSPEPQRLPLQLERTMRT
RYKIDTYQQTYFVIDSFEQLFAMTEPDFGPVYERLRGQAEFAADEREAVAA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=240, Percent_Identity=34.1666666666667, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI4759248, Length=217, Percent_Identity=34.1013824884793, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI88900503, Length=251, Percent_Identity=35.0597609561753, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI88900505, Length=251, Percent_Identity=35.0597609561753, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI88900501, Length=251, Percent_Identity=35.0597609561753, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI31795563, Length=218, Percent_Identity=33.9449541284404, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17531391, Length=217, Percent_Identity=37.3271889400922, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71980736, Length=224, Percent_Identity=34.375, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI115532103, Length=231, Percent_Identity=29.4372294372294, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115533973, Length=231, Percent_Identity=29.4372294372294, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71980731, Length=152, Percent_Identity=31.5789473684211, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24660393, Length=220, Percent_Identity=36.3636363636364, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62472054, Length=220, Percent_Identity=36.3636363636364, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17136774, Length=217, Percent_Identity=34.1013824884793, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136776, Length=217, Percent_Identity=34.1013824884793, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24654994, Length=219, Percent_Identity=32.4200913242009, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33123; Mature: 32992

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIPAHCITRRHAMGQAPVVYGQSDRPPRGDYARAGSDYTCAQDYAAYTPQDHDTYRRLY
CCCCHHHHHHHHHCCCCCEEECCCCCCCCCCHHHCCCCCCHHHHHHHCCCCCHHHHHHHH
ARQSALLPGRASEAFIAALPSLGASDRIPRFDEINERLQRATGWEIVGVPGLIPEVPFFT
HHHHHCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCHHH
LLANRKFPVTDWIRTPEEFDYIVEPDIFHDLFGHVPLLFNPVFADYVQRYGQGGLKAHGL
HHCCCCCCHHHHHCCHHHCCEEECCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GACEMLSRLYWYTIEFGLIRERGALRAYGAGILSSSGELEYSVNSPEPQRLPLQLERTMR
CHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHCCCCCCEEEECCCCCCCCCCHHHHHHHH
TRYKIDTYQQTYFVIDSFEQLFAMTEPDFGPVYERLRGQAEFAADEREAVAA
HHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHCCCCHHHHCC
>Mature Secondary Structure 
GIPAHCITRRHAMGQAPVVYGQSDRPPRGDYARAGSDYTCAQDYAAYTPQDHDTYRRLY
CCCHHHHHHHHHCCCCCEEECCCCCCCCCCHHHCCCCCCHHHHHHHCCCCCHHHHHHHH
ARQSALLPGRASEAFIAALPSLGASDRIPRFDEINERLQRATGWEIVGVPGLIPEVPFFT
HHHHHCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCHHH
LLANRKFPVTDWIRTPEEFDYIVEPDIFHDLFGHVPLLFNPVFADYVQRYGQGGLKAHGL
HHCCCCCCHHHHHCCHHHCCEEECCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GACEMLSRLYWYTIEFGLIRERGALRAYGAGILSSSGELEYSVNSPEPQRLPLQLERTMR
CHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHCCCCCCEEEECCCCCCCCCCHHHHHHHH
TRYKIDTYQQTYFVIDSFEQLFAMTEPDFGPVYERLRGQAEFAADEREAVAA
HHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]