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The map label for this gene is fabA [H]

Identifier: 120612818

GI number: 120612818

Start: 4633264

End: 4633806

Strand: Reverse

Name: fabA [H]

Synonym: Aave_4181

Alternate gene names: 120612818

Gene position: 4633806-4633264 (Counterclockwise)

Preceding gene: 120612819

Following gene: 120612817

Centisome position: 86.57

GC content: 66.67

Gene sequence:

>543_bases
ATGGCTGAATCCTTTTCCTATGAACAACTGATCGCCTCGGGCGAAGGCAGGCTGTTCACCCCTGACAGCGGACGACTCCC
GCTGCCGCCCATGCTGATGTTCGACCGCATCACGCACATCGACGCCGACGGCGGCGCGCACGGGCTGGGGAAGATTCGCG
CCGAACTGGACGTGCGGCCGGATCTCTGGTTCTTCGACTGCCACTTCCAGGGCGACCCGGTCATGCCGGGCTGCCTGGGC
CTGGACGCGATGTGGCAGCTCATCGGTTTCTACCTGACCTGGCTGCAACTGCCGGGCCGGGGGCGCGCACTGGGCGCGGG
CGAGGTCAAGTTCACCGGCGAGGTGGGCCCCAACGTCAAGCTCGTCACCTACGAGATCGACATCAAGCGCGTCATCAAGC
GCAAGCTGGTCATGGCGATCGGCGATGCGCGCCTGCTGGCCGACGGCCAGGAAATCTATGTGGCCTCCGATCTGCGCGTG
GGCCTGTTCAAGAAGGAAGACGCCGCGGCGGCTGCGCCGGCGCGGGAGGAGGCGGGGGCATGA

Upstream 100 bases:

>100_bases
TACGCCGCAGACTGGATAATGCGCATCCGCGGCCCTCGGCGATGCAAGGGCCGCGCACACGAAACGCGGCGCTGCGCGCC
GACCTGGAGCACGACTGACA

Downstream 100 bases:

>100_bases
GCATGAGAAAGCGTGTCGTCATCACCGGCGCGGGCATCGTTTCCTGCATCGGCAACGACCTCGCCACCGTGGAGGCCTCG
CTGCGCGAGAGCCGCCCGGG

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MAESFSYEQLIASGEGRLFTPDSGRLPLPPMLMFDRITHIDADGGAHGLGKIRAELDVRPDLWFFDCHFQGDPVMPGCLG
LDAMWQLIGFYLTWLQLPGRGRALGAGEVKFTGEVGPNVKLVTYEIDIKRVIKRKLVMAIGDARLLADGQEIYVASDLRV
GLFKKEDAAAAAPAREEAGA

Sequences:

>Translated_180_residues
MAESFSYEQLIASGEGRLFTPDSGRLPLPPMLMFDRITHIDADGGAHGLGKIRAELDVRPDLWFFDCHFQGDPVMPGCLG
LDAMWQLIGFYLTWLQLPGRGRALGAGEVKFTGEVGPNVKLVTYEIDIKRVIKRKLVMAIGDARLLADGQEIYVASDLRV
GLFKKEDAAAAAPAREEAGA
>Mature_179_residues
AESFSYEQLIASGEGRLFTPDSGRLPLPPMLMFDRITHIDADGGAHGLGKIRAELDVRPDLWFFDCHFQGDPVMPGCLGL
DAMWQLIGFYLTWLQLPGRGRALGAGEVKFTGEVGPNVKLVTYEIDIKRVIKRKLVMAIGDARLLADGQEIYVASDLRVG
LFKKEDAAAAAPAREEAGA

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP [H]

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787187, Length=166, Percent_Identity=58.433734939759, Blast_Score=205, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114 [H]

Pfam domain/function: PF07977 FabA [H]

EC number: =4.2.1.60 [H]

Molecular weight: Translated: 19676; Mature: 19545

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESFSYEQLIASGEGRLFTPDSGRLPLPPMLMFDRITHIDADGGAHGLGKIRAELDVRP
CCCCCCHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHEECCCCCCCCCEEEEEEEECCC
DLWFFDCHFQGDPVMPGCLGLDAMWQLIGFYLTWLQLPGRGRALGAGEVKFTGEVGPNVK
CEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCCCEE
LVTYEIDIKRVIKRKLVMAIGDARLLADGQEIYVASDLRVGLFKKEDAAAAAPAREEAGA
EEEEECCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEEECCCCCCCCCCHHHCCC
>Mature Secondary Structure 
AESFSYEQLIASGEGRLFTPDSGRLPLPPMLMFDRITHIDADGGAHGLGKIRAELDVRP
CCCCCHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHEECCCCCCCCCEEEEEEEECCC
DLWFFDCHFQGDPVMPGCLGLDAMWQLIGFYLTWLQLPGRGRALGAGEVKFTGEVGPNVK
CEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCCCEE
LVTYEIDIKRVIKRKLVMAIGDARLLADGQEIYVASDLRVGLFKKEDAAAAAPAREEAGA
EEEEECCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEEECCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]