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The map label for this gene is fabB [H]

Identifier: 120612817

GI number: 120612817

Start: 4632041

End: 4633267

Strand: Reverse

Name: fabB [H]

Synonym: Aave_4180

Alternate gene names: 120612817

Gene position: 4633267-4632041 (Counterclockwise)

Preceding gene: 120612818

Following gene: 120612815

Centisome position: 86.56

GC content: 69.36

Gene sequence:

>1227_bases
ATGAGCATGAGAAAGCGTGTCGTCATCACCGGCGCGGGCATCGTTTCCTGCATCGGCAACGACCTCGCCACCGTGGAGGC
CTCGCTGCGCGAGAGCCGCCCGGGCATCCGTGCCATGCCGAAGTTCACCGAACTGGGCATGCGCAGCCAGGTGGCTGGCG
TGCCCGACATCGACCTGGAAGCGCGCATCGACCGCAAGCAGCTGCGCTTCATGGGCGATGCCGCGGCCTATGCCCACATC
GCCCTGGAAGACGCCATTGCCCAGTCGGGCCTGGCGCCGGACCAGGTCTCGCACCCGCGCACCGGCCTCATCATGGGTTC
GGGCGGAGGCTCGCCCGAGAACCAGATCGAGTCCGCCGACATCCTGCGCTCCAAGGGCATCCGCCGCGTGGGGCCCTACC
AGGTCACGCGCTGCATGAGCTCGACCGTCTCGGCCTGCCTCTCGACGAACTTCGGCATCAAGGGCATCAACTATTCGATC
ACCTCGGCCTGCAGCACGTCCGCGCACTGCATCGGCGCGGCGGCCCAGCAGATCGCCTGGGGCATGCAGGACGTGATGTT
CGCCGGCGGCGGCGAAGAGGTCACCTGGGGCATGGGGCTGCTGTTCGACGCCATGGGCGCGATGTCCAGCAAGTACAACG
ACACGCCCGAGAAAGCCTCGCGCGCCTACGACGCGAACCGCGACGGCTTCGTGCTGTCGGGCGGCGGCGGTGCCGTGGTG
CTCGAAAGCCTGGAGCATGCCCAGGCGCGCGGCGCCACCATCCTCGGCGAGGTGATCGGGTTCGGCGCCACGTCCGACGG
CGCCGACATGGTCGCGCCCTCGGGCGACGGTGCCATCGCGTGCATGCGCCAGGCCATCGAGGGCCTGGACGCGCCCATCG
ACTACATCAATACCCACGGAACCTCCACCCCCGTGGGCGACGTGCCGGAACTGCGCGCCATCCGCGCGGTCTTCGGCGAC
GCGGTGCCGCCGTTCTCCTCCACCAAGTCGCTCACCGGCCACTCGCTGGGCGCCACCGGGGTGCAGGAGGCGATCTACTG
CCTCATCATGCTGCAGAAGGGCTTCATCGCCGGCTCCGCCAATGTCGAGACGCCCGACCCCGCCGTGGAAGGCATGCCCC
TGGCGACCGCCACGCGCGAGGCACCGCTGCGTACCGCGCTGTCCAACAGCTTCGGCTTCGGCGGCACGAATGCCAGCCTG
GTGCTGCGGCGCTGGGACGGTCAGTAG

Upstream 100 bases:

>100_bases
CCGACGGCCAGGAAATCTATGTGGCCTCCGATCTGCGCGTGGGCCTGTTCAAGAAGGAAGACGCCGCGGCGGCTGCGCCG
GCGCGGGAGGAGGCGGGGGC

Downstream 100 bases:

>100_bases
TTCTCGTTGACGTCGCGGAACGGGCCGAACTTCGCCCGGCGGTAGGCCTGCGGCTGGCCGGGGAAATGCTCCGGGATCGC
GAAGCCCTGCGGTCGCAGGG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSMRKRVVITGAGIVSCIGNDLATVEASLRESRPGIRAMPKFTELGMRSQVAGVPDIDLEARIDRKQLRFMGDAAAYAHI
ALEDAIAQSGLAPDQVSHPRTGLIMGSGGGSPENQIESADILRSKGIRRVGPYQVTRCMSSTVSACLSTNFGIKGINYSI
TSACSTSAHCIGAAAQQIAWGMQDVMFAGGGEEVTWGMGLLFDAMGAMSSKYNDTPEKASRAYDANRDGFVLSGGGGAVV
LESLEHAQARGATILGEVIGFGATSDGADMVAPSGDGAIACMRQAIEGLDAPIDYINTHGTSTPVGDVPELRAIRAVFGD
AVPPFSSTKSLTGHSLGATGVQEAIYCLIMLQKGFIAGSANVETPDPAVEGMPLATATREAPLRTALSNSFGFGGTNASL
VLRRWDGQ

Sequences:

>Translated_408_residues
MSMRKRVVITGAGIVSCIGNDLATVEASLRESRPGIRAMPKFTELGMRSQVAGVPDIDLEARIDRKQLRFMGDAAAYAHI
ALEDAIAQSGLAPDQVSHPRTGLIMGSGGGSPENQIESADILRSKGIRRVGPYQVTRCMSSTVSACLSTNFGIKGINYSI
TSACSTSAHCIGAAAQQIAWGMQDVMFAGGGEEVTWGMGLLFDAMGAMSSKYNDTPEKASRAYDANRDGFVLSGGGGAVV
LESLEHAQARGATILGEVIGFGATSDGADMVAPSGDGAIACMRQAIEGLDAPIDYINTHGTSTPVGDVPELRAIRAVFGD
AVPPFSSTKSLTGHSLGATGVQEAIYCLIMLQKGFIAGSANVETPDPAVEGMPLATATREAPLRTALSNSFGFGGTNASL
VLRRWDGQ
>Mature_407_residues
SMRKRVVITGAGIVSCIGNDLATVEASLRESRPGIRAMPKFTELGMRSQVAGVPDIDLEARIDRKQLRFMGDAAAYAHIA
LEDAIAQSGLAPDQVSHPRTGLIMGSGGGSPENQIESADILRSKGIRRVGPYQVTRCMSSTVSACLSTNFGIKGINYSIT
SACSTSAHCIGAAAQQIAWGMQDVMFAGGGEEVTWGMGLLFDAMGAMSSKYNDTPEKASRAYDANRDGFVLSGGGGAVVL
ESLEHAQARGATILGEVIGFGATSDGADMVAPSGDGAIACMRQAIEGLDAPIDYINTHGTSTPVGDVPELRAIRAVFGDA
VPPFSSTKSLTGHSLGATGVQEAIYCLIMLQKGFIAGSANVETPDPAVEGMPLATATREAPLRTALSNSFGFGGTNASLV
LRRWDGQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=424, Percent_Identity=33.7264150943396, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=29.5522388059701, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI223972627, Length=164, Percent_Identity=37.8048780487805, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788663, Length=402, Percent_Identity=61.4427860696517, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=38.6473429951691, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=34.7087378640777, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=38.6100386100386, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=402, Percent_Identity=27.363184079602, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=24.9299719887955, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=452, Percent_Identity=29.4247787610619, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=36.9928400954654, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19920632, Length=380, Percent_Identity=28.9473684210526, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI221330659, Length=380, Percent_Identity=28.9473684210526, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24581345, Length=380, Percent_Identity=25.5263157894737, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42369; Mature: 42237

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMRKRVVITGAGIVSCIGNDLATVEASLRESRPGIRAMPKFTELGMRSQVAGVPDIDLE
CCCCCEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHCCHHHCCCCCCCCHH
ARIDRKQLRFMGDAAAYAHIALEDAIAQSGLAPDQVSHPRTGLIMGSGGGSPENQIESAD
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHH
ILRSKGIRRVGPYQVTRCMSSTVSACLSTNFGIKGINYSITSACSTSAHCIGAAAQQIAW
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCHHHHHHHHHHHHH
GMQDVMFAGGGEEVTWGMGLLFDAMGAMSSKYNDTPEKASRAYDANRDGFVLSGGGGAVV
HHHHHHEECCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCCHH
LESLEHAQARGATILGEVIGFGATSDGADMVAPSGDGAIACMRQAIEGLDAPIDYINTHG
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCHHHHHCCC
TSTPVGDVPELRAIRAVFGDAVPPFSSTKSLTGHSLGATGVQEAIYCLIMLQKGFIAGSA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCC
NVETPDPAVEGMPLATATREAPLRTALSNSFGFGGTNASLVLRRWDGQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
SMRKRVVITGAGIVSCIGNDLATVEASLRESRPGIRAMPKFTELGMRSQVAGVPDIDLE
CCCCEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHCCHHHCCCCCCCCHH
ARIDRKQLRFMGDAAAYAHIALEDAIAQSGLAPDQVSHPRTGLIMGSGGGSPENQIESAD
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHH
ILRSKGIRRVGPYQVTRCMSSTVSACLSTNFGIKGINYSITSACSTSAHCIGAAAQQIAW
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCHHHHHHHHHHHHH
GMQDVMFAGGGEEVTWGMGLLFDAMGAMSSKYNDTPEKASRAYDANRDGFVLSGGGGAVV
HHHHHHEECCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCCHH
LESLEHAQARGATILGEVIGFGATSDGADMVAPSGDGAIACMRQAIEGLDAPIDYINTHG
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCHHHHHCCC
TSTPVGDVPELRAIRAVFGDAVPPFSSTKSLTGHSLGATGVQEAIYCLIMLQKGFIAGSA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCC
NVETPDPAVEGMPLATATREAPLRTALSNSFGFGGTNASLVLRRWDGQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]