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The map label for this gene is ahcY [H]

Identifier: 120612697

GI number: 120612697

Start: 4510367

End: 4511794

Strand: Reverse

Name: ahcY [H]

Synonym: Aave_4060

Alternate gene names: 120612697

Gene position: 4511794-4510367 (Counterclockwise)

Preceding gene: 120612705

Following gene: 120612696

Centisome position: 84.29

GC content: 64.92

Gene sequence:

>1428_bases
ATGAGCGCAGTTCTCAAGCCCCAGGCCGACCTGGCCATTGCCGACATTTCCCTGGCCGACTGGGGCCGCAAGGAAATCAA
GATCGCCGAAACCGAGATGCCCGGCCTGATGGCCATCCGCGAGGAATTCGCGGCGGCGCAGCCCCTCAAGGGCGCGCGCA
TCACCGGCTCGCTGCACATGACCATCCAGACGGCCGTGCTGATCGAGACGCTGAAGGCCCTGGGCGCCGACGTGCGCTGG
GCCTCGTGCAACATATTCTCCACGCAGGACCACGCCGCCGCCGCCATCGCCGCGGGCGGCACGCCGGTGTTCGCCATAAA
GGGCGAATCGCTGGAAGACTACTGGGACTACACCCACCGCATCTTCGACTTCGGCGCCAAGGGTACGCCGGGCGAAGGCC
CGAACATGATCCTGGACGACGGCGGCGACGCCACGCTGCTGATGCACCTGGGCCAGCGCGCCGAGAAGGATCTGTCCGTG
GTGGCCAACCCCACGAGCGAAGAAGAGCGCATCCTGTTCGCCGCCATCAAGGCCAAGATCGCGCAGGATCCGACCTGGTA
CACCCGCAAGTCGGCCGAGATCATCGGCGTGACGGAAGAAACGACGACCGGCGTGCACCGTCTGAACGAGATGTCCGCCA
AGGGCACGCTGCTGTTCCGCGCGATCAACGTGAACGACTCGGTCACGAAGTCGAAGTTCGACAACCTCTACGGCTGCCGC
GAATCGCTGGTGGACGGCATCAAGCGCGCCACCGACGTGATGATCGCCGGCAAGGTGGCCCTGGTGGCCGGCTACGGCGA
CGTGGGCAAGGGCTGCGCCCAGGCCCTGGCCGCCCTGCGCGCCCAGGTGTGGGTGACCGAGATCGACCCCATCAACGCCC
TGCAGGCCGCGATGGAAGGCTACAAGGTCGTGACGATGGAATACGCCGCCGACAAGGCCGACATCTTCGTGACCACCACC
GGCAACAAGGACGTGATCCGCCACGAGCACATGGTGGCCATGAAGAACGAGGCCATCGTCTGCAACATCGGCCACTTCGA
CAACGAGATCGACGTCGCCTCGATCGAGAAGTACCGGTGGGAAGAGGTGAAGCCGCAGGTGGACCACGTGATCTTCCCGG
ACGGCAAGCGCATCACCCTGCTGGCCAAGGGCCGCCTGGTGAACCTGGGCTGCGCCACGGGCCATCCGAGCTTCGTGATG
TCGTCCTCCTTCGCCAACCAGACCATCGCGCAGATCGAACTGTTCACCAAGCCCGACGCCTACCAGGCCGGCAAGGTCTA
TGTGCTGCCCAAGGTGCTGGACGAGAAGGTCGCACGCCTGCACCTGAAGAAGGTCGGCGCCCAGCTCACCGAGCTGACCG
ATGCGCAGGCCGCCTATATCGGCGTGAAGAAGGAAGGCCCTTACAAGGCCGACACGTATAGGTACTGA

Upstream 100 bases:

>100_bases
CGGGTCATCATTTTGCAACGACGCTCGCCCACGCTGTCCGGTGCGGTGAGCGAGCCATTGGCCGAACGCGTGGTTTTTGA
ACTCTTCAACGGAGAAAACC

Downstream 100 bases:

>100_bases
CATCCCCCTGAGGCGCCAGTGGCCCGGCGGAGCCGGTTCCACGGCGTCTGCTGGCGTGGGGGCGTGCGGGTGCCTGGCGA
ACAGCAAGCGCTGAGGACCG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSAVLKPQADLAIADISLADWGRKEIKIAETEMPGLMAIREEFAAAQPLKGARITGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAAGGTPVFAIKGESLEDYWDYTHRIFDFGAKGTPGEGPNMILDDGGDATLLMHLGQRAEKDLSV
VANPTSEEERILFAAIKAKIAQDPTWYTRKSAEIIGVTEETTTGVHRLNEMSAKGTLLFRAINVNDSVTKSKFDNLYGCR
ESLVDGIKRATDVMIAGKVALVAGYGDVGKGCAQALAALRAQVWVTEIDPINALQAAMEGYKVVTMEYAADKADIFVTTT
GNKDVIRHEHMVAMKNEAIVCNIGHFDNEIDVASIEKYRWEEVKPQVDHVIFPDGKRITLLAKGRLVNLGCATGHPSFVM
SSSFANQTIAQIELFTKPDAYQAGKVYVLPKVLDEKVARLHLKKVGAQLTELTDAQAAYIGVKKEGPYKADTYRY

Sequences:

>Translated_475_residues
MSAVLKPQADLAIADISLADWGRKEIKIAETEMPGLMAIREEFAAAQPLKGARITGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAAGGTPVFAIKGESLEDYWDYTHRIFDFGAKGTPGEGPNMILDDGGDATLLMHLGQRAEKDLSV
VANPTSEEERILFAAIKAKIAQDPTWYTRKSAEIIGVTEETTTGVHRLNEMSAKGTLLFRAINVNDSVTKSKFDNLYGCR
ESLVDGIKRATDVMIAGKVALVAGYGDVGKGCAQALAALRAQVWVTEIDPINALQAAMEGYKVVTMEYAADKADIFVTTT
GNKDVIRHEHMVAMKNEAIVCNIGHFDNEIDVASIEKYRWEEVKPQVDHVIFPDGKRITLLAKGRLVNLGCATGHPSFVM
SSSFANQTIAQIELFTKPDAYQAGKVYVLPKVLDEKVARLHLKKVGAQLTELTDAQAAYIGVKKEGPYKADTYRY
>Mature_474_residues
SAVLKPQADLAIADISLADWGRKEIKIAETEMPGLMAIREEFAAAQPLKGARITGSLHMTIQTAVLIETLKALGADVRWA
SCNIFSTQDHAAAAIAAGGTPVFAIKGESLEDYWDYTHRIFDFGAKGTPGEGPNMILDDGGDATLLMHLGQRAEKDLSVV
ANPTSEEERILFAAIKAKIAQDPTWYTRKSAEIIGVTEETTTGVHRLNEMSAKGTLLFRAINVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKVALVAGYGDVGKGCAQALAALRAQVWVTEIDPINALQAAMEGYKVVTMEYAADKADIFVTTTG
NKDVIRHEHMVAMKNEAIVCNIGHFDNEIDVASIEKYRWEEVKPQVDHVIFPDGKRITLLAKGRLVNLGCATGHPSFVMS
SSFANQTIAQIELFTKPDAYQAGKVYVLPKVLDEKVARLHLKKVGAQLTELTDAQAAYIGVKKEGPYKADTYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=466, Percent_Identity=59.2274678111588, Blast_Score=510, Evalue=1e-145,
Organism=Homo sapiens, GI239937451, Length=446, Percent_Identity=58.9686098654709, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI298286489, Length=472, Percent_Identity=49.5762711864407, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI195539349, Length=472, Percent_Identity=49.5762711864407, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI195539337, Length=472, Percent_Identity=49.5762711864407, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI24308043, Length=472, Percent_Identity=49.5762711864407, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI21361647, Length=472, Percent_Identity=48.0932203389831, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17506425, Length=468, Percent_Identity=59.4017094017094, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320882, Length=486, Percent_Identity=57.6131687242798, Blast_Score=509, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24642172, Length=465, Percent_Identity=60.4301075268817, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24656245, Length=473, Percent_Identity=49.0486257928118, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553387, Length=468, Percent_Identity=48.2905982905983, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45553385, Length=467, Percent_Identity=48.1798715203426, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51693; Mature: 51562

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVLKPQADLAIADISLADWGRKEIKIAETEMPGLMAIREEFAAAQPLKGARITGSLHM
CCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAIKGESLEDYWDYTHR
EHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHH
IFDFGAKGTPGEGPNMILDDGGDATLLMHLGQRAEKDLSVVANPTSEEERILFAAIKAKI
HHHCCCCCCCCCCCCEEEECCCCEEEEEHHCCCCCCCCEEEECCCCCHHHEEHEEHHHHH
AQDPTWYTRKSAEIIGVTEETTTGVHRLNEMSAKGTLLFRAINVNDSVTKSKFDNLYGCR
CCCCCCEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
ESLVDGIKRATDVMIAGKVALVAGYGDVGKGCAQALAALRAQVWVTEIDPINALQAAMEG
HHHHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHCC
YKVVTMEYAADKADIFVTTTGNKDVIRHEHMVAMKNEAIVCNIGHFDNEIDVASIEKYRW
CEEEEEEECCCCCCEEEEECCCCCHHHHHHEEEECCCEEEEEECCCCCCCCHHHHHHHHH
EEVKPQVDHVIFPDGKRITLLAKGRLVNLGCATGHPSFVMSSSFANQTIAQIELFTKPDA
HHCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCCEEECCCCCCEEEEEEEEECCCC
YQAGKVYVLPKVLDEKVARLHLKKVGAQLTELTDAQAAYIGVKKEGPYKADTYRY
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SAVLKPQADLAIADISLADWGRKEIKIAETEMPGLMAIREEFAAAQPLKGARITGSLHM
CCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAIKGESLEDYWDYTHR
EHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHH
IFDFGAKGTPGEGPNMILDDGGDATLLMHLGQRAEKDLSVVANPTSEEERILFAAIKAKI
HHHCCCCCCCCCCCCEEEECCCCEEEEEHHCCCCCCCCEEEECCCCCHHHEEHEEHHHHH
AQDPTWYTRKSAEIIGVTEETTTGVHRLNEMSAKGTLLFRAINVNDSVTKSKFDNLYGCR
CCCCCCEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
ESLVDGIKRATDVMIAGKVALVAGYGDVGKGCAQALAALRAQVWVTEIDPINALQAAMEG
HHHHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHCC
YKVVTMEYAADKADIFVTTTGNKDVIRHEHMVAMKNEAIVCNIGHFDNEIDVASIEKYRW
CEEEEEEECCCCCCEEEEECCCCCHHHHHHEEEECCCEEEEEECCCCCCCCHHHHHHHHH
EEVKPQVDHVIFPDGKRITLLAKGRLVNLGCATGHPSFVMSSSFANQTIAQIELFTKPDA
HHCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCCEEECCCCCCEEEEEEEEECCCC
YQAGKVYVLPKVLDEKVARLHLKKVGAQLTELTDAQAAYIGVKKEGPYKADTYRY
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA