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The map label for this gene is mdtD [H]

Identifier: 120612685

GI number: 120612685

Start: 4499501

End: 4500949

Strand: Reverse

Name: mdtD [H]

Synonym: Aave_4048

Alternate gene names: 120612685

Gene position: 4500949-4499501 (Counterclockwise)

Preceding gene: 120612686

Following gene: 120612682

Centisome position: 84.09

GC content: 70.46

Gene sequence:

>1449_bases
ATGTCCTCCAGCTCCGCAGCCGAGATATCCCCTCCGCCAGGTCCTGCCCCGGACCGCCGCATCCTGCTGTGGATCGTCGC
GGTGGGCTTCTTCATGCAGACGCTGGACGCGACGATCGTCAACACGGCCCTGCCGGCGATGGCTGCCAGCCTGGGCGAAA
GCCCGCTGCGCATGCAGTCGGTGATCGTCGCGTATTCGCTCACCATGGCCATGCTGATCCCCGCCTCGGGCTGGCTGGCC
GACCGCTTCGGCACGCGCACGGTGTTCCTGTTCGCCATCGCCGTTTTCTCGCTCGGCTCGCTGGCCTGCGCGGCATCGCG
GCACTTGGGGGAGCTGGTCGCGGCGCGCGTGCTGCAGGGACTGGGCGGCGCGCTGCTGCTGCCCGTGGGGCGCCTGGCGG
TGCTGCGCACGTTCCCCCGGGGCGAATTCCTGGAGGCGATGAGCTTCGTCGCCATTCCGGGGCTGATCGGTCCTTTGCTG
GGGCCCACCCTGGGGGGCTGGCTGGTGCAGAGCGCATCGTGGCACTGGGTGTTCCTCATCAACCTGCCGGTGGGCCTGAT
CGGCATGCTCGCGACGGCCCGCTTCATGCCCGTGCTGCGGGCCGAGCGGCCCGATCCCTTCGATACCGCGGGCTACGTGC
TGCTGGCTTTCGGCATGGTGGCCATATCGCTGGCCATCGAGGCGGCGGGCGTGGCGGGCCGCGGCGGGGCGGCGGCCCTG
GGCGTCGGCGGGCTCGTGGCGCTGGTCGTGTACTGGCTGCATGCGGCGCGCCACGAACGGCCGCTGTACTCGCCGCACCT
GTTCCGTGTGCGGACCCTGTCCGTCGGGCTGCTGGGCAATCTGTTCTGCCGCCTGGGCAGCGGGGCGATGCCGTTCCTGA
TACCTGTGTCGCTGCAACTGCTGCTGGGGTACTCGCCGCTGCATGCCGGCATGATGATGCTGCCCGCAGCCCTCGCGGGC
ATGGCCGTCAAGCGCGTGGCGACGCCGCTGATCCGCCGCTGCGGCTACCGCAACGTCCTGGTCGCCAACACCGCCATGCT
GGGGATGCTGATGGCCAGCTTCGCGCTGCGCGAACCCGGCTGGCCGCTGGCGTGGCAGGTGCTGCAGCTGGCGGCCTTCG
GTGCCGTCAATTCCCTGCAGTTCTCGGCGATGAACACCATCACCCTCAAGGACCTGGACGGTGCCAGCGCCAGCAGCGGC
AACGGCCTGCTGTCGATGGTGCAGATGCTGGCCATGAGCCTGGGCGTGGCGGTGGCCGGCGCGGTGCTTTCGGAATGGAG
CCAGGCGTACGGCGGTCCGGAGGTGCCCGGCGCGGTGCTGCACGCCTTCCAGTCCACCTTCCTGACGGTGGGCTTCATCA
CCATCGCCTCGGCTGCCGTGTTCTGGCAACTGCCCCTGGAGGCGCGGACGCCGCCCCGCGAAGGGCCCGAGGTCTCGGGC
CAGGGATGA

Upstream 100 bases:

>100_bases
CCTGCGGCTGCGGATCGAGCTTCTCGGTCTGACCGCCTCCGTGTGAGAGCAAGCCGCCCGAGGGCGGCTTTTTTGTTCCT
GCAGAAGCCGTCTCTCCCCC

Downstream 100 bases:

>100_bases
GGGCGGGGCGCCGAGGCCCTGCCGTCAGGCCGGGTGGATGGCGCCGAGCACGCGTGGGCCCGCGGCACCGGTCACCCGGG
GCAGGTTGCCCGGCAGCCCG

Product: major facilitator superfamily transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSSSSAAEISPPPGPAPDRRILLWIVAVGFFMQTLDATIVNTALPAMAASLGESPLRMQSVIVAYSLTMAMLIPASGWLA
DRFGTRTVFLFAIAVFSLGSLACAASRHLGELVAARVLQGLGGALLLPVGRLAVLRTFPRGEFLEAMSFVAIPGLIGPLL
GPTLGGWLVQSASWHWVFLINLPVGLIGMLATARFMPVLRAERPDPFDTAGYVLLAFGMVAISLAIEAAGVAGRGGAAAL
GVGGLVALVVYWLHAARHERPLYSPHLFRVRTLSVGLLGNLFCRLGSGAMPFLIPVSLQLLLGYSPLHAGMMMLPAALAG
MAVKRVATPLIRRCGYRNVLVANTAMLGMLMASFALREPGWPLAWQVLQLAAFGAVNSLQFSAMNTITLKDLDGASASSG
NGLLSMVQMLAMSLGVAVAGAVLSEWSQAYGGPEVPGAVLHAFQSTFLTVGFITIASAAVFWQLPLEARTPPREGPEVSG
QG

Sequences:

>Translated_482_residues
MSSSSAAEISPPPGPAPDRRILLWIVAVGFFMQTLDATIVNTALPAMAASLGESPLRMQSVIVAYSLTMAMLIPASGWLA
DRFGTRTVFLFAIAVFSLGSLACAASRHLGELVAARVLQGLGGALLLPVGRLAVLRTFPRGEFLEAMSFVAIPGLIGPLL
GPTLGGWLVQSASWHWVFLINLPVGLIGMLATARFMPVLRAERPDPFDTAGYVLLAFGMVAISLAIEAAGVAGRGGAAAL
GVGGLVALVVYWLHAARHERPLYSPHLFRVRTLSVGLLGNLFCRLGSGAMPFLIPVSLQLLLGYSPLHAGMMMLPAALAG
MAVKRVATPLIRRCGYRNVLVANTAMLGMLMASFALREPGWPLAWQVLQLAAFGAVNSLQFSAMNTITLKDLDGASASSG
NGLLSMVQMLAMSLGVAVAGAVLSEWSQAYGGPEVPGAVLHAFQSTFLTVGFITIASAAVFWQLPLEARTPPREGPEVSG
QG
>Mature_481_residues
SSSSAAEISPPPGPAPDRRILLWIVAVGFFMQTLDATIVNTALPAMAASLGESPLRMQSVIVAYSLTMAMLIPASGWLAD
RFGTRTVFLFAIAVFSLGSLACAASRHLGELVAARVLQGLGGALLLPVGRLAVLRTFPRGEFLEAMSFVAIPGLIGPLLG
PTLGGWLVQSASWHWVFLINLPVGLIGMLATARFMPVLRAERPDPFDTAGYVLLAFGMVAISLAIEAAGVAGRGGAAALG
VGGLVALVVYWLHAARHERPLYSPHLFRVRTLSVGLLGNLFCRLGSGAMPFLIPVSLQLLLGYSPLHAGMMMLPAALAGM
AVKRVATPLIRRCGYRNVLVANTAMLGMLMASFALREPGWPLAWQVLQLAAFGAVNSLQFSAMNTITLKDLDGASASSGN
GLLSMVQMLAMSLGVAVAGAVLSEWSQAYGGPEVPGAVLHAFQSTFLTVGFITIASAAVFWQLPLEARTPPREGPEVSGQ
G

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=440, Percent_Identity=50, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1788392, Length=463, Percent_Identity=49.6760259179266, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1789042, Length=406, Percent_Identity=27.5862068965517, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081983, Length=429, Percent_Identity=29.3706293706294, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788710, Length=331, Percent_Identity=29.607250755287, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788509, Length=136, Percent_Identity=33.0882352941176, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=129, Percent_Identity=34.1085271317829, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321663, Length=154, Percent_Identity=32.4675324675325, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50510; Mature: 50378

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSSAAEISPPPGPAPDRRILLWIVAVGFFMQTLDATIVNTALPAMAASLGESPLRMQS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VIVAYSLTMAMLIPASGWLADRFGTRTVFLFAIAVFSLGSLACAASRHLGELVAARVLQG
HHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGGALLLPVGRLAVLRTFPRGEFLEAMSFVAIPGLIGPLLGPTLGGWLVQSASWHWVFLI
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
NLPVGLIGMLATARFMPVLRAERPDPFDTAGYVLLAFGMVAISLAIEAAGVAGRGGAAAL
ECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
GVGGLVALVVYWLHAARHERPLYSPHLFRVRTLSVGLLGNLFCRLGSGAMPFLIPVSLQL
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LLGYSPLHAGMMMLPAALAGMAVKRVATPLIRRCGYRNVLVANTAMLGMLMASFALREPG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
WPLAWQVLQLAAFGAVNSLQFSAMNTITLKDLDGASASSGNGLLSMVQMLAMSLGVAVAG
CHHHHHHHHHHHHCCCCCCEEHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AVLSEWSQAYGGPEVPGAVLHAFQSTFLTVGFITIASAAVFWQLPLEARTPPREGPEVSG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCC
QG
CC
>Mature Secondary Structure 
SSSSAAEISPPPGPAPDRRILLWIVAVGFFMQTLDATIVNTALPAMAASLGESPLRMQS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VIVAYSLTMAMLIPASGWLADRFGTRTVFLFAIAVFSLGSLACAASRHLGELVAARVLQG
HHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGGALLLPVGRLAVLRTFPRGEFLEAMSFVAIPGLIGPLLGPTLGGWLVQSASWHWVFLI
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
NLPVGLIGMLATARFMPVLRAERPDPFDTAGYVLLAFGMVAISLAIEAAGVAGRGGAAAL
ECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
GVGGLVALVVYWLHAARHERPLYSPHLFRVRTLSVGLLGNLFCRLGSGAMPFLIPVSLQL
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LLGYSPLHAGMMMLPAALAGMAVKRVATPLIRRCGYRNVLVANTAMLGMLMASFALREPG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
WPLAWQVLQLAAFGAVNSLQFSAMNTITLKDLDGASASSGNGLLSMVQMLAMSLGVAVAG
CHHHHHHHHHHHHCCCCCCEEHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AVLSEWSQAYGGPEVPGAVLHAFQSTFLTVGFITIASAAVFWQLPLEARTPPREGPEVSG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCC
QG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA