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The map label for this gene is pcaR [H]

Identifier: 120612586

GI number: 120612586

Start: 4372564

End: 4373367

Strand: Direct

Name: pcaR [H]

Synonym: Aave_3947

Alternate gene names: 120612586

Gene position: 4372564-4373367 (Clockwise)

Preceding gene: 120612575

Following gene: 120612587

Centisome position: 81.69

GC content: 69.03

Gene sequence:

>804_bases
ATGAGCGATACCCCCACGGATATTGGTAAAAACCCTAGGCCGGGCGACAGCTACGTGCAGTCGTTCGCCCGCGGGCTGGA
AGTGATCCGTTCCTTCAGCGCCGCCGCGCCGCAGCAGACGTTGAGCGAAGTAGCGGCCTCATCGGGCCTCACGCGTGCGG
GGGCGCGCCGCATCCTGCTCACGCTGCAGACGCTGGGCTACGTGGAAAGCGACGGGCGGCTGTTCCGCCTCACGCCGCGC
ATCATGGACCTGGGTTTCGCCTACCTCTCGTCCATGCCCATCTGGGATCTCGCGGAGCCCTCCATGGAAGCGCTGGCCGG
CGAGGTGCGCGAATCGTGCTCGGCCGCCGTGCTGGACGGGCACGACATCGTCTATGTGCTGCGCATCCACACCCACAAGA
TCATGAGCACCAACCTGGGCGTGGGCTCGCGCCTGCCCGCGTTCTGGACGTCCATGGGCCGCATGCTGCTGGCCGGCCTG
CCCGACGAGCGCGTCATCGCGCTCATGAACGACCTGCCACGCAAGCGCTTCACGCCGCGCACCGTGGTCGAGGACGCGGA
ACTGCTCGCCCGTGTGCAGACCGCCCGCGCGCAGGGCTGGTGCCTGATCGACCAGGAACTGGAGGAAGGGCTGATCTCTG
TCGCCGCCCCGCTGCGCGACCGCGCCGGCCGCACGGTGGCCGCGCTCAACATCAGCGGACAGGCCAACCGCACCAGCGCG
AAGGTGATGCAGCGCGACCTGCTGCCCGTACTGCTGCGCACGGCCGACACCATCTCTGGGCTGCTGGGCACGCGGCGCGG
CTGA

Upstream 100 bases:

>100_bases
GGCCCCGCGAGCGGGAGGCAACCGGCTGCCCGGTTGCGAAATTTTGTTCGCGTAAAGAACAAATGTTCGTACAATGAATT
AATTCTAGAACCAACGGCTT

Downstream 100 bases:

>100_bases
GGCCGCGCCCCCCGCGCGGCCCCCTTCAGCCCGACAGTTCCGTAACACAATCCCGGCCCCGGTGGGCCTGCGCCGGCCGG
CGGCTTCGCATTCCGCGCGA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSDTPTDIGKNPRPGDSYVQSFARGLEVIRSFSAAAPQQTLSEVAASSGLTRAGARRILLTLQTLGYVESDGRLFRLTPR
IMDLGFAYLSSMPIWDLAEPSMEALAGEVRESCSAAVLDGHDIVYVLRIHTHKIMSTNLGVGSRLPAFWTSMGRMLLAGL
PDERVIALMNDLPRKRFTPRTVVEDAELLARVQTARAQGWCLIDQELEEGLISVAAPLRDRAGRTVAALNISGQANRTSA
KVMQRDLLPVLLRTADTISGLLGTRRG

Sequences:

>Translated_267_residues
MSDTPTDIGKNPRPGDSYVQSFARGLEVIRSFSAAAPQQTLSEVAASSGLTRAGARRILLTLQTLGYVESDGRLFRLTPR
IMDLGFAYLSSMPIWDLAEPSMEALAGEVRESCSAAVLDGHDIVYVLRIHTHKIMSTNLGVGSRLPAFWTSMGRMLLAGL
PDERVIALMNDLPRKRFTPRTVVEDAELLARVQTARAQGWCLIDQELEEGLISVAAPLRDRAGRTVAALNISGQANRTSA
KVMQRDLLPVLLRTADTISGLLGTRRG
>Mature_266_residues
SDTPTDIGKNPRPGDSYVQSFARGLEVIRSFSAAAPQQTLSEVAASSGLTRAGARRILLTLQTLGYVESDGRLFRLTPRI
MDLGFAYLSSMPIWDLAEPSMEALAGEVRESCSAAVLDGHDIVYVLRIHTHKIMSTNLGVGSRLPAFWTSMGRMLLAGLP
DERVIALMNDLPRKRFTPRTVVEDAELLARVQTARAQGWCLIDQELEEGLISVAAPLRDRAGRTVAALNISGQANRTSAK
VMQRDLLPVLLRTADTISGLLGTRRG

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=225, Percent_Identity=29.3333333333333, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1786468, Length=222, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI87082359, Length=243, Percent_Identity=26.7489711934156, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786715, Length=240, Percent_Identity=25, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789999, Length=259, Percent_Identity=29.7297297297297, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29057; Mature: 28926

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTPTDIGKNPRPGDSYVQSFARGLEVIRSFSAAAPQQTLSEVAASSGLTRAGARRILL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
TLQTLGYVESDGRLFRLTPRIMDLGFAYLSSMPIWDLAEPSMEALAGEVRESCSAAVLDG
HHHHHCEECCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCEEEECC
HDIVYVLRIHTHKIMSTNLGVGSRLPAFWTSMGRMLLAGLPDERVIALMNDLPRKRFTPR
CCEEEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHCCCCH
TVVEDAELLARVQTARAQGWCLIDQELEEGLISVAAPLRDRAGRTVAALNISGQANRTSA
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHH
KVMQRDLLPVLLRTADTISGLLGTRRG
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDTPTDIGKNPRPGDSYVQSFARGLEVIRSFSAAAPQQTLSEVAASSGLTRAGARRILL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
TLQTLGYVESDGRLFRLTPRIMDLGFAYLSSMPIWDLAEPSMEALAGEVRESCSAAVLDG
HHHHHCEECCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCEEEECC
HDIVYVLRIHTHKIMSTNLGVGSRLPAFWTSMGRMLLAGLPDERVIALMNDLPRKRFTPR
CCEEEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHCCCCH
TVVEDAELLARVQTARAQGWCLIDQELEEGLISVAAPLRDRAGRTVAALNISGQANRTSA
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHH
KVMQRDLLPVLLRTADTISGLLGTRRG
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]