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The map label for this gene is ctaB

Identifier: 120612538

GI number: 120612538

Start: 4322527

End: 4323435

Strand: Reverse

Name: ctaB

Synonym: Aave_3899

Alternate gene names: 120612538

Gene position: 4323435-4322527 (Counterclockwise)

Preceding gene: 120612539

Following gene: 120612537

Centisome position: 80.77

GC content: 66.78

Gene sequence:

>909_bases
ATGAGTGCCGCTTCCGCTTCCACCGCCCCCCAGGCGGTTTCGTCCCGCTTCTCGCAGTTCTACGCGCTGACCAAGCCGCG
CGTGGTCCAGCTCATCGTTTTCTGCGCATTCATCGGCATGGTGCTCGCGGTGCCCGGCCTGCCGAGCGGGGAGCAGTGGC
TGCACATGGCCATCGCCTGCTTCGGGATCTGGCTGGTCGCCGGGGCCGCGGCCGCCTTCAACTGCCTCGTGGAGCAGCAC
ATCGACGCCAGGATGAACCGCACCGCCTGGCGCCCCACGGCCAAGGGCGAACTCTCCAACGCCCAGACGCTCGCTTTCTC
GGCCCTGCTGTGCCTGGCCGGCTCGCTCGTGCTCTTCGTCTGGGTCAATGCGCTCACCATGTGGCTCACCTTCGCCACCT
TCGTGGGCTACGCGGTCATCTACACCGTCGTGCTCAAGCCGCGCACGCCGCAGAACATCGTCATCGGCGGAGCCTCCGGC
GCCATGCCGCCGGTGCTGGGCTGGGCGTCCATGACGGGCGACGTGGGGCCGGAGCCGCTGATCCTCTTCCTCATCATCTT
CCTCTGGACCCCGCCCCATTTCTGGGCGCTCGCCCTCTACCGCGTGGAGGACTACCGCAAGTCCGGCCTGCCCATGCTGC
CCGTCACCCACGGCAACGAGTTCACCCGCCTGCAGGTGCTGCTCTACACCTTCATCCTGTTCGCCGGCTGCCTGATGCCC
TTCGTGTACGGCATGAGCTCCTGGATCTACCTGGCCGCGGCGGTGGTGCTCTGCACCGGCTTCTGCGCTTATGCCTTCCG
CCTCTGGCGCAACTATTCCGACGCGCTCGCGCGCAAGACCTTCCGCTTCTCCCTCATCCACCTGAGCCTGCTTTTCGCGG
CGCTGCTGGTGGACCATTACGTGCTCTGA

Upstream 100 bases:

>100_bases
CCTGGACCCTGGCCGCCAGCCGGGCCGTGGGCGCCAGGGACAAAATGTCCACCCCCCGCGCGATTGAAACCGCCGCGGGC
GCCCCGAGAATTTCTTCGCC

Downstream 100 bases:

>100_bases
ACCGCCATGCCCATGCACAAACGCACTCTCCTTCGCAGCGCAGCGGCCTGCGCCCTGTTCGCCGGCGCGGCGGGCCTGCT
CGGGGGCTGCTCCCAGGAAA

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSAASASTAPQAVSSRFSQFYALTKPRVVQLIVFCAFIGMVLAVPGLPSGEQWLHMAIACFGIWLVAGAAAAFNCLVEQH
IDARMNRTAWRPTAKGELSNAQTLAFSALLCLAGSLVLFVWVNALTMWLTFATFVGYAVIYTVVLKPRTPQNIVIGGASG
AMPPVLGWASMTGDVGPEPLILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVLLYTFILFAGCLMP
FVYGMSSWIYLAAAVVLCTGFCAYAFRLWRNYSDALARKTFRFSLIHLSLLFAALLVDHYVL

Sequences:

>Translated_302_residues
MSAASASTAPQAVSSRFSQFYALTKPRVVQLIVFCAFIGMVLAVPGLPSGEQWLHMAIACFGIWLVAGAAAAFNCLVEQH
IDARMNRTAWRPTAKGELSNAQTLAFSALLCLAGSLVLFVWVNALTMWLTFATFVGYAVIYTVVLKPRTPQNIVIGGASG
AMPPVLGWASMTGDVGPEPLILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVLLYTFILFAGCLMP
FVYGMSSWIYLAAAVVLCTGFCAYAFRLWRNYSDALARKTFRFSLIHLSLLFAALLVDHYVL
>Mature_301_residues
SAASASTAPQAVSSRFSQFYALTKPRVVQLIVFCAFIGMVLAVPGLPSGEQWLHMAIACFGIWLVAGAAAAFNCLVEQHI
DARMNRTAWRPTAKGELSNAQTLAFSALLCLAGSLVLFVWVNALTMWLTFATFVGYAVIYTVVLKPRTPQNIVIGGASGA
MPPVLGWASMTGDVGPEPLILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVLLYTFILFAGCLMPF
VYGMSSWIYLAAAVVLCTGFCAYAFRLWRNYSDALARKTFRFSLIHLSLLFAALLVDHYVL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=261, Percent_Identity=29.5019157088123, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786631, Length=286, Percent_Identity=31.1188811188811, Blast_Score=141, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71998235, Length=223, Percent_Identity=28.6995515695067, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325085, Length=291, Percent_Identity=27.1477663230241, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19921064, Length=283, Percent_Identity=29.3286219081272, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_ACIAC (A1TU04)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972216.1
- STRING:   A1TU04
- GeneID:   4665094
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3899
- NMPDR:   fig|397945.5.peg.3329
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   A1TU04
- ProtClustDB:   PRK04375
- BioCyc:   AAVE397945:AAVE_3899-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33297; Mature: 33166

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x16d5d00c)-; HASH(0x17a5e504)-; HASH(0x17a58b18)-; HASH(0x17a5bcb4)-; HASH(0x17b1ab48)-; HASH(0x173167a8)-; HASH(0x17a5e69c)-; HASH(0x179677fc)-;

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAASASTAPQAVSSRFSQFYALTKPRVVQLIVFCAFIGMVLAVPGLPSGEQWLHMAIAC
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
FGIWLVAGAAAAFNCLVEQHIDARMNRTAWRPTAKGELSNAQTLAFSALLCLAGSLVLFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
WVNALTMWLTFATFVGYAVIYTVVLKPRTPQNIVIGGASGAMPPVLGWASMTGDVGPEPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCCHHH
ILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVLLYTFILFAGCLMP
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
FVYGMSSWIYLAAAVVLCTGFCAYAFRLWRNYSDALARKTFRFSLIHLSLLFAALLVDHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VL
CH
>Mature Secondary Structure 
SAASASTAPQAVSSRFSQFYALTKPRVVQLIVFCAFIGMVLAVPGLPSGEQWLHMAIAC
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH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CH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA