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The map label for this gene is gpmA

Identifier: 120612499

GI number: 120612499

Start: 4284275

End: 4285018

Strand: Direct

Name: gpmA

Synonym: Aave_3858

Alternate gene names: 120612499

Gene position: 4284275-4285018 (Clockwise)

Preceding gene: 120612494

Following gene: 120612500

Centisome position: 80.04

GC content: 68.28

Gene sequence:

>744_bases
ATGCACAAACTCGTCCTGATCCGCCACGGCGAATCCACCTGGAACCTCGAAAACCGCTTCACCGGCTGGACCGACGTGGA
CCTGACGCCCACCGGCATCGAACAGGCCAAGACCGCCGGCCGTCTCCTGAAGGCCGAAGGTTACGAGTTCGACCTGGCCT
TCACCAGCGTGCTCAAGCGCGCCACGCGCACGCTGTGGCACGTCCTGGACGAGATGGACCGCACCTGGCTGCCCGTGGAG
CACAGCTGGCGCCTCAACGAGCGCCACTACGGCGCCCTGCAGGGGCTCAACAAGGCCGACATGGCCAAACAGTACGGCGA
TGCGCAGGTACTCGTCTGGCGCCGCAGCTACGACACGCCCCCGCCGGCCCTGGAAGCCGGCGATCCGCGCAGCGAGCGCG
GCGACATCCGCTATGCCGGCCTCGACCCCGAGCAGATCCCCCTCACCGAGTGCCTGAAGGACACGGTGGCCCGGGTGCTG
CCCTTCTGGAACGAGCGCATCGCGCCCGCGATGCGGTCGGGCCAGCGCGTGATGGTGGCCGCCCACGGCAACTCGATCCG
GGCGCTGGTCAAGTACCTGGACGGCATCTCGGACGACGACATCGTCGGGCTGAACATTCCCAACGGCATCCCCCTGGTCT
ATGAGCTCGACGATGACCTGAAGCCGCTGCGCCACTACTACCTCGGCGACGCCGAGGCCGCGGCCAAGGCTGCCGCCGCA
GTGGCGTCCCAGGGCAAGGCCTGA

Upstream 100 bases:

>100_bases
TGTCGATGATGAAATTCACGGAAGTCCTTGGGGAAAGCAAACCGCGCAATTTTAGAATGCGGAGTTTTACCCGACCGCAT
CCACTGCTTCTCACGCCACC

Downstream 100 bases:

>100_bases
CCGAGGCCGCCTGTCGGCGGCCATGCCGGGGCGGCCTTCCGTCCCGGGAAACCCCGCGGGGTGCGCCACGATGCGCCAAA
AAGCCCCGCGGGCGCGGAAC

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MHKLVLIRHGESTWNLENRFTGWTDVDLTPTGIEQAKTAGRLLKAEGYEFDLAFTSVLKRATRTLWHVLDEMDRTWLPVE
HSWRLNERHYGALQGLNKADMAKQYGDAQVLVWRRSYDTPPPALEAGDPRSERGDIRYAGLDPEQIPLTECLKDTVARVL
PFWNERIAPAMRSGQRVMVAAHGNSIRALVKYLDGISDDDIVGLNIPNGIPLVYELDDDLKPLRHYYLGDAEAAAKAAAA
VASQGKA

Sequences:

>Translated_247_residues
MHKLVLIRHGESTWNLENRFTGWTDVDLTPTGIEQAKTAGRLLKAEGYEFDLAFTSVLKRATRTLWHVLDEMDRTWLPVE
HSWRLNERHYGALQGLNKADMAKQYGDAQVLVWRRSYDTPPPALEAGDPRSERGDIRYAGLDPEQIPLTECLKDTVARVL
PFWNERIAPAMRSGQRVMVAAHGNSIRALVKYLDGISDDDIVGLNIPNGIPLVYELDDDLKPLRHYYLGDAEAAAKAAAA
VASQGKA
>Mature_247_residues
MHKLVLIRHGESTWNLENRFTGWTDVDLTPTGIEQAKTAGRLLKAEGYEFDLAFTSVLKRATRTLWHVLDEMDRTWLPVE
HSWRLNERHYGALQGLNKADMAKQYGDAQVLVWRRSYDTPPPALEAGDPRSERGDIRYAGLDPEQIPLTECLKDTVARVL
PFWNERIAPAMRSGQRVMVAAHGNSIRALVKYLDGISDDDIVGLNIPNGIPLVYELDDDLKPLRHYYLGDAEAAAKAAAA
VASQGKA

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=249, Percent_Identity=55.8232931726908, Blast_Score=301, Evalue=4e-82,
Organism=Homo sapiens, GI4505753, Length=249, Percent_Identity=59.8393574297189, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI71274132, Length=249, Percent_Identity=57.429718875502, Blast_Score=287, Evalue=6e-78,
Organism=Homo sapiens, GI4502445, Length=251, Percent_Identity=49.402390438247, Blast_Score=267, Evalue=8e-72,
Organism=Homo sapiens, GI40353764, Length=251, Percent_Identity=49.402390438247, Blast_Score=267, Evalue=8e-72,
Organism=Homo sapiens, GI310129614, Length=162, Percent_Identity=61.7283950617284, Blast_Score=194, Evalue=6e-50,
Organism=Escherichia coli, GI1786970, Length=245, Percent_Identity=63.6734693877551, Blast_Score=325, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=53.6585365853659, Blast_Score=255, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6324516, Length=292, Percent_Identity=35.2739726027397, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320183, Length=296, Percent_Identity=33.445945945946, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324857, Length=192, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646216, Length=256, Percent_Identity=50, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI85725270, Length=250, Percent_Identity=52.8, Blast_Score=257, Evalue=5e-69,
Organism=Drosophila melanogaster, GI85725272, Length=250, Percent_Identity=52.8, Blast_Score=257, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24650981, Length=250, Percent_Identity=52.8, Blast_Score=257, Evalue=5e-69,
Organism=Drosophila melanogaster, GI28571815, Length=250, Percent_Identity=37.6, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28571817, Length=250, Percent_Identity=37.6, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24648979, Length=250, Percent_Identity=37.6, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_ACIAC (A1TTW5)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972177.1
- ProteinModelPortal:   A1TTW5
- SMR:   A1TTW5
- STRING:   A1TTW5
- GeneID:   4666934
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3858
- NMPDR:   fig|397945.5.peg.3291
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   A1TTW5
- ProtClustDB:   PRK14115
- BioCyc:   AAVE397945:AAVE_3858-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 27689; Mature: 27689

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKLVLIRHGESTWNLENRFTGWTDVDLTPTGIEQAKTAGRLLKAEGYEFDLAFTSVLKR
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHH
ATRTLWHVLDEMDRTWLPVEHSWRLNERHYGALQGLNKADMAKQYGDAQVLVWRRSYDTP
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHCCCEEEEEEECCCCCC
PPALEAGDPRSERGDIRYAGLDPEQIPLTECLKDTVARVLPFWNERIAPAMRSGQRVMVA
CCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSIRALVKYLDGISDDDIVGLNIPNGIPLVYELDDDLKPLRHYYLGDAEAAAKAAAA
ECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHH
VASQGKA
HHHCCCC
>Mature Secondary Structure
MHKLVLIRHGESTWNLENRFTGWTDVDLTPTGIEQAKTAGRLLKAEGYEFDLAFTSVLKR
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHH
ATRTLWHVLDEMDRTWLPVEHSWRLNERHYGALQGLNKADMAKQYGDAQVLVWRRSYDTP
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHCCCEEEEEEECCCCCC
PPALEAGDPRSERGDIRYAGLDPEQIPLTECLKDTVARVLPFWNERIAPAMRSGQRVMVA
CCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSIRALVKYLDGISDDDIVGLNIPNGIPLVYELDDDLKPLRHYYLGDAEAAAKAAAA
ECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHH
VASQGKA
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA