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The map label for this gene is 120612462

Identifier: 120612462

GI number: 120612462

Start: 4242806

End: 4244209

Strand: Direct

Name: 120612462

Synonym: Aave_3821

Alternate gene names: NA

Gene position: 4242806-4244209 (Clockwise)

Preceding gene: 120612453

Following gene: 120612464

Centisome position: 79.26

GC content: 69.59

Gene sequence:

>1404_bases
ATGTCAGCAATCCATCACTTGAGCGCGGCCGAACTCGCGGCCGGCTACAGCCGCCGGGCGCTATCCCCGGTCGAGGTTCT
CGATGCCCTCCTCGCCCGGGTGGAGCAGACGTCCCGCAGCCTGAACGCCTTCTGCTGCGTGGATACGGAGGCAGCGATGC
GGCAGGCCCGCGCCTCCGAGGCGCGCTGGCACCGGGGACAGGCGCTCGGTCCGCTCGATGGCGTGCCGGTATCGATCAAG
GACAACCTGGGCACCGCCGGCATGCCGACCCGCTTCGGATCCCTGGCCGTGGGCGAAGCCGCGGCGCAGCTGCCCGACAG
CCCCTGCGTGGAGCGGCTCCGGGAGGCGGGCGCCGTGTTCATCGGCAAGACCACCATGCCGGACTTCGCGCACAAGATCC
TCACCGACAGCCCCCTCACCGGCATTACCCGCAACCCGTGGAATCCGGAGTACTCCCCTGGGGGATCCAGTGGCGGAGCG
GCAGCCGCCGTTGCCGCAGGGCTCGGGCCGATCGCCGTGGGAACGGACGGCGGAGGCTCCATCCGCATCCCGGCGGCGTT
CACCGGCATCTATGGGTTCAAGCCCAGCTTCGGGCGTGTGCCCCATTACCCGCGCGGCGCCTTCGCCCTGCTCAGCCATG
TCGGCCCGATGACGCGCACCGTGGAAGATGCCGCCATCGTCATGAACACCATCACCCGGCCCGATCCTCGCGACTGGTAT
GCGTTGCCCTACCGGACGACGGACTACCAAGCGGGACTGCGCGAATCCCTGGCGGGATGGAAGATCGCGTTCAGCCCGTC
GCTGGGACTCGATACCCCGCCCTGCCCGGAAACACTCGACGCACTCAAGCACAGTGCGCGCATCCTGGAATCGCTCGGTG
CCCACATCGAGATGCGGGACCCTCCGGCCGTCGCGCAGTGCCAGCGCATCCATCGCGTGCTGTGGTCCGCTTTCTGCGCC
AAGCTGGCGGATTCGCTCGGGAGCGAAGCGTCCGCGCAGCTGGACGTCTCGCTGCGCATGCTCGTCGAGGCTGGCCGCGC
GCTGCAGCCCGGGGAGGTGCTGGACGCCTTGACCCAGCGGGGCGAGGCCGGATGCAGTGTCAACGGCTTTTTCACGGAGT
ACGACCTGGTCCTGTGTCCCGTGCATCCCGCCACGGCGCCCCTGCTGGCGGCATGCCCGGCCTCGGATCCTCCTTATCCC
CTCTACACCCCATGGTGCAACCAGTTGGGCCTGCCGGCCGCGAGCGTGTATGCCGGGCATGCCGCGAACGGCCTTCCCAT
CGGCGTGCAGCTGGTCGGAAGGCAGCACGACGATGCCGCCGTTCTCGCGGCGAGCCATGCCTACGAACGTGCAGTCGGAC
GCGCCGACGGGCTGCTGCGCGATGGCGCCGGCACGGCGGCATAG

Upstream 100 bases:

>100_bases
CCCTCGTACTTGCATGGAAAGAATTTCACCGTTACATGCAACGTAACTCTTCAATCTTTCGCCAATTTATGATCATAATT
AAGAAAAAGGAGATACGACC

Downstream 100 bases:

>100_bases
GAGGAACGGTCGTGCCGCCGGCCGTGCGCGGCGACCGTCCGGGCTGCCGCTGTGCACGGTGGCCCGGACGAAGAGACTAC
CTCGCGGTCGGCATGACGAA

Product: amidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSAIHHLSAAELAAGYSRRALSPVEVLDALLARVEQTSRSLNAFCCVDTEAAMRQARASEARWHRGQALGPLDGVPVSIK
DNLGTAGMPTRFGSLAVGEAAAQLPDSPCVERLREAGAVFIGKTTMPDFAHKILTDSPLTGITRNPWNPEYSPGGSSGGA
AAAVAAGLGPIAVGTDGGGSIRIPAAFTGIYGFKPSFGRVPHYPRGAFALLSHVGPMTRTVEDAAIVMNTITRPDPRDWY
ALPYRTTDYQAGLRESLAGWKIAFSPSLGLDTPPCPETLDALKHSARILESLGAHIEMRDPPAVAQCQRIHRVLWSAFCA
KLADSLGSEASAQLDVSLRMLVEAGRALQPGEVLDALTQRGEAGCSVNGFFTEYDLVLCPVHPATAPLLAACPASDPPYP
LYTPWCNQLGLPAASVYAGHAANGLPIGVQLVGRQHDDAAVLAASHAYERAVGRADGLLRDGAGTAA

Sequences:

>Translated_467_residues
MSAIHHLSAAELAAGYSRRALSPVEVLDALLARVEQTSRSLNAFCCVDTEAAMRQARASEARWHRGQALGPLDGVPVSIK
DNLGTAGMPTRFGSLAVGEAAAQLPDSPCVERLREAGAVFIGKTTMPDFAHKILTDSPLTGITRNPWNPEYSPGGSSGGA
AAAVAAGLGPIAVGTDGGGSIRIPAAFTGIYGFKPSFGRVPHYPRGAFALLSHVGPMTRTVEDAAIVMNTITRPDPRDWY
ALPYRTTDYQAGLRESLAGWKIAFSPSLGLDTPPCPETLDALKHSARILESLGAHIEMRDPPAVAQCQRIHRVLWSAFCA
KLADSLGSEASAQLDVSLRMLVEAGRALQPGEVLDALTQRGEAGCSVNGFFTEYDLVLCPVHPATAPLLAACPASDPPYP
LYTPWCNQLGLPAASVYAGHAANGLPIGVQLVGRQHDDAAVLAASHAYERAVGRADGLLRDGAGTAA
>Mature_466_residues
SAIHHLSAAELAAGYSRRALSPVEVLDALLARVEQTSRSLNAFCCVDTEAAMRQARASEARWHRGQALGPLDGVPVSIKD
NLGTAGMPTRFGSLAVGEAAAQLPDSPCVERLREAGAVFIGKTTMPDFAHKILTDSPLTGITRNPWNPEYSPGGSSGGAA
AAVAAGLGPIAVGTDGGGSIRIPAAFTGIYGFKPSFGRVPHYPRGAFALLSHVGPMTRTVEDAAIVMNTITRPDPRDWYA
LPYRTTDYQAGLRESLAGWKIAFSPSLGLDTPPCPETLDALKHSARILESLGAHIEMRDPPAVAQCQRIHRVLWSAFCAK
LADSLGSEASAQLDVSLRMLVEAGRALQPGEVLDALTQRGEAGCSVNGFFTEYDLVLCPVHPATAPLLAACPASDPPYPL
YTPWCNQLGLPAASVYAGHAANGLPIGVQLVGRQHDDAAVLAASHAYERAVGRADGLLRDGAGTAA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amidase family [H]

Homologues:

Organism=Homo sapiens, GI222831590, Length=507, Percent_Identity=27.6134122287968, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI195972892, Length=490, Percent_Identity=26.530612244898, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI166795287, Length=209, Percent_Identity=35.8851674641148, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537465, Length=492, Percent_Identity=24.1869918699187, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17556264, Length=214, Percent_Identity=34.5794392523364, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17543272, Length=469, Percent_Identity=27.9317697228145, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71990152, Length=336, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17538252, Length=522, Percent_Identity=26.0536398467433, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17556278, Length=200, Percent_Identity=31.5, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17556276, Length=200, Percent_Identity=31.5, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17538254, Length=321, Percent_Identity=26.791277258567, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32565337, Length=229, Percent_Identity=27.5109170305677, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=393, Percent_Identity=27.735368956743, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320448, Length=358, Percent_Identity=27.3743016759777, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323950, Length=425, Percent_Identity=26.8235294117647, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356731, Length=479, Percent_Identity=27.7661795407098, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45550774, Length=482, Percent_Identity=25.3112033195021, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24648435, Length=482, Percent_Identity=25.3112033195021, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24648437, Length=482, Percent_Identity=25.3112033195021, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24644968, Length=487, Percent_Identity=24.435318275154, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161078093, Length=491, Percent_Identity=26.8839103869654, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24648441, Length=410, Percent_Identity=25.609756097561, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24648439, Length=410, Percent_Identity=25.609756097561, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24648113, Length=240, Percent_Identity=37.5, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24652985, Length=234, Percent_Identity=31.6239316239316, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922090, Length=234, Percent_Identity=31.6239316239316, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24652981, Length=234, Percent_Identity=31.6239316239316, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24652983, Length=234, Percent_Identity=31.6239316239316, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000120
- InterPro:   IPR020556 [H]

Pfam domain/function: PF01425 Amidase [H]

EC number: =3.5.1.4 [H]

Molecular weight: Translated: 48950; Mature: 48819

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00435 PEROXIDASE_1 ; PS00571 AMIDASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIHHLSAAELAAGYSRRALSPVEVLDALLARVEQTSRSLNAFCCVDTEAAMRQARASE
CCHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
ARWHRGQALGPLDGVPVSIKDNLGTAGMPTRFGSLAVGEAAAQLPDSPCVERLREAGAVF
HHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCEEE
IGKTTMPDFAHKILTDSPLTGITRNPWNPEYSPGGSSGGAAAAVAAGLGPIAVGTDGGGS
EECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCE
IRIPAAFTGIYGFKPSFGRVPHYPRGAFALLSHVGPMTRTVEDAAIVMNTITRPDPRDWY
EECCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCE
ALPYRTTDYQAGLRESLAGWKIAFSPSLGLDTPPCPETLDALKHSARILESLGAHIEMRD
ECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECC
PPAVAQCQRIHRVLWSAFCAKLADSLGSEASAQLDVSLRMLVEAGRALQPGEVLDALTQR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GEAGCSVNGFFTEYDLVLCPVHPATAPLLAACPASDPPYPLYTPWCNQLGLPAASVYAGH
CCCCCCCCCEEEEEEEEEECCCCCCCCHHEECCCCCCCCCCCCCCHHHHCCCHHHHHCCC
AANGLPIGVQLVGRQHDDAAVLAASHAYERAVGRADGLLRDGAGTAA
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure 
SAIHHLSAAELAAGYSRRALSPVEVLDALLARVEQTSRSLNAFCCVDTEAAMRQARASE
CHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
ARWHRGQALGPLDGVPVSIKDNLGTAGMPTRFGSLAVGEAAAQLPDSPCVERLREAGAVF
HHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCEEE
IGKTTMPDFAHKILTDSPLTGITRNPWNPEYSPGGSSGGAAAAVAAGLGPIAVGTDGGGS
EECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCE
IRIPAAFTGIYGFKPSFGRVPHYPRGAFALLSHVGPMTRTVEDAAIVMNTITRPDPRDWY
EECCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCE
ALPYRTTDYQAGLRESLAGWKIAFSPSLGLDTPPCPETLDALKHSARILESLGAHIEMRD
ECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECC
PPAVAQCQRIHRVLWSAFCAKLADSLGSEASAQLDVSLRMLVEAGRALQPGEVLDALTQR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GEAGCSVNGFFTEYDLVLCPVHPATAPLLAACPASDPPYPLYTPWCNQLGLPAASVYAGH
CCCCCCCCCEEEEEEEEEECCCCCCCCHHEECCCCCCCCCCCCCCHHHHCCCHHHHHCCC
AANGLPIGVQLVGRQHDDAAVLAASHAYERAVGRADGLLRDGAGTAA
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]