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The map label for this gene is ptxR [H]

Identifier: 120612464

GI number: 120612464

Start: 4245914

End: 4246858

Strand: Direct

Name: ptxR [H]

Synonym: Aave_3823

Alternate gene names: 120612464

Gene position: 4245914-4246858 (Clockwise)

Preceding gene: 120612462

Following gene: 120612472

Centisome position: 79.32

GC content: 66.67

Gene sequence:

>945_bases
ATGAAAACCAAGAAGGTCGATGCGCTCTGGTCCCACGTGCACTGGCTCGGGATCCTGGACGCGGAAGGCAGCTTCACGGG
CGCGGCGCATCGGCTGGGCGTGAGCAAGTCGGCGGTCAGCCACCGGGTATCGGAGCTGGAGCAGGCTGCCGGCGTCGCGC
TGGTGAGGCGTACCACCCGCACCGTCCGCCTCACGGATGCGGGCAGGCACCTGGTCGATTCCACGCGCGAGTCGTTCGCG
TCGATCGAGCGCAGCTTCGCGAACATCAGGGATCTCGCGCAGGAGCCCAATGGCGTGCTGAGGGTGACGGTGCCGGTGGC
GTTCGGCAGGCAACATATCGTGCCCCGAATCCCCGGTTTCCTGCGGCAGTACCCGCAGGTCCGCGTCGAACTCGAGCTCT
CCGACGGTATCCGCTCCCTCAGCCTGGACGGCTTCGATCTGGCGATCCGCCACGTGGAGTCCGTTCCGGACACCCATGTC
GCATGGCCGCTGTGCCCGACCGAGACCGTCCTGGTGGCCAGCAGAGCCTATCTGGAGGCCTGCGGCGTTCCCGGGACGCC
ACACGATCTGGCGCGGCACAACTGCCTGCACTATCTGCGCGGTGCGTCGGTGCCCAGCTGGAGTTTCGAACGCACCGGAC
ACCGGGCCGACGCGCCACGCTTGAGCATTCCCATTGCAGGCACCTTCGCGGCGAACAACAGTGAAGCGTTGCGCACGCTG
GCGATCGCCGGCGCCGGTATTGCGATGCTGCCGGACTTCAGCGTCTCCGGCGAGATCGGCAATGGAGAACTCGTGCGGGT
TCTACCCGGATGGCGGCCGGTGGGCGCATTCGGCACACGCATTTCCGCCGTGAGGACCTTCAGCACCCATGTCCCGAGGG
CGGTACGCGTGTTCGTAGCCTACCTGCGCGAGTCGATGCATGGTGGATTCCTGCAGGCATCCTAG

Upstream 100 bases:

>100_bases
CCTTTGCGTTGAATGACATGCCAAAGTCTAGGAACGCCCTCCCCGCGGAACAAGCCAGAAGCGCTGCACGGACTGTTCTT
GCTTTTTGACAATCGGACGA

Downstream 100 bases:

>100_bases
AGCGGCCCCTCACTCCGCCGCCCGCCGCAGCGTCTCCACCACCGGCCGCCGCAGCACTTCCCGCAGCCCCCACCAACCGG
CAGCCAGGGCCAGCAGCGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKTKKVDALWSHVHWLGILDAEGSFTGAAHRLGVSKSAVSHRVSELEQAAGVALVRRTTRTVRLTDAGRHLVDSTRESFA
SIERSFANIRDLAQEPNGVLRVTVPVAFGRQHIVPRIPGFLRQYPQVRVELELSDGIRSLSLDGFDLAIRHVESVPDTHV
AWPLCPTETVLVASRAYLEACGVPGTPHDLARHNCLHYLRGASVPSWSFERTGHRADAPRLSIPIAGTFAANNSEALRTL
AIAGAGIAMLPDFSVSGEIGNGELVRVLPGWRPVGAFGTRISAVRTFSTHVPRAVRVFVAYLRESMHGGFLQAS

Sequences:

>Translated_314_residues
MKTKKVDALWSHVHWLGILDAEGSFTGAAHRLGVSKSAVSHRVSELEQAAGVALVRRTTRTVRLTDAGRHLVDSTRESFA
SIERSFANIRDLAQEPNGVLRVTVPVAFGRQHIVPRIPGFLRQYPQVRVELELSDGIRSLSLDGFDLAIRHVESVPDTHV
AWPLCPTETVLVASRAYLEACGVPGTPHDLARHNCLHYLRGASVPSWSFERTGHRADAPRLSIPIAGTFAANNSEALRTL
AIAGAGIAMLPDFSVSGEIGNGELVRVLPGWRPVGAFGTRISAVRTFSTHVPRAVRVFVAYLRESMHGGFLQAS
>Mature_314_residues
MKTKKVDALWSHVHWLGILDAEGSFTGAAHRLGVSKSAVSHRVSELEQAAGVALVRRTTRTVRLTDAGRHLVDSTRESFA
SIERSFANIRDLAQEPNGVLRVTVPVAFGRQHIVPRIPGFLRQYPQVRVELELSDGIRSLSLDGFDLAIRHVESVPDTHV
AWPLCPTETVLVASRAYLEACGVPGTPHDLARHNCLHYLRGASVPSWSFERTGHRADAPRLSIPIAGTFAANNSEALRTL
AIAGAGIAMLPDFSVSGEIGNGELVRVLPGWRPVGAFGTRISAVRTFSTHVPRAVRVFVAYLRESMHGGFLQAS

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=281, Percent_Identity=29.1814946619217, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1786401, Length=290, Percent_Identity=32.0689655172414, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1787128, Length=250, Percent_Identity=30.8, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI87081978, Length=282, Percent_Identity=28.7234042553192, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789639, Length=262, Percent_Identity=32.824427480916, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI145693193, Length=279, Percent_Identity=29.7491039426523, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787589, Length=276, Percent_Identity=27.536231884058, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788706, Length=300, Percent_Identity=25, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789173, Length=259, Percent_Identity=27.7992277992278, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786448, Length=245, Percent_Identity=26.1224489795918, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786713, Length=262, Percent_Identity=30.1526717557252, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI157672245, Length=127, Percent_Identity=33.0708661417323, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788748, Length=111, Percent_Identity=36.9369369369369, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34137; Mature: 34137

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKKVDALWSHVHWLGILDAEGSFTGAAHRLGVSKSAVSHRVSELEQAAGVALVRRTTR
CCCCHHHHHHHHHHEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
TVRLTDAGRHLVDSTRESFASIERSFANIRDLAQEPNGVLRVTVPVAFGRQHIVPRIPGF
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCHH
LRQYPQVRVELELSDGIRSLSLDGFDLAIRHVESVPDTHVAWPLCPTETVLVASRAYLEA
HHCCCCEEEEEEECCCCCEECCCCHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHH
CGVPGTPHDLARHNCLHYLRGASVPSWSFERTGHRADAPRLSIPIAGTFAANNSEALRTL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCEEEEEEEEEEECCCHHHHHHH
AIAGAGIAMLPDFSVSGEIGNGELVRVLPGWRPVGAFGTRISAVRTFSTHVPRAVRVFVA
HHHCCCEEECCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
YLRESMHGGFLQAS
HHHHHHCCCEEECC
>Mature Secondary Structure
MKTKKVDALWSHVHWLGILDAEGSFTGAAHRLGVSKSAVSHRVSELEQAAGVALVRRTTR
CCCCHHHHHHHHHHEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
TVRLTDAGRHLVDSTRESFASIERSFANIRDLAQEPNGVLRVTVPVAFGRQHIVPRIPGF
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCHH
LRQYPQVRVELELSDGIRSLSLDGFDLAIRHVESVPDTHVAWPLCPTETVLVASRAYLEA
HHCCCCEEEEEEECCCCCEECCCCHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHH
CGVPGTPHDLARHNCLHYLRGASVPSWSFERTGHRADAPRLSIPIAGTFAANNSEALRTL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCEEEEEEEEEEECCCHHHHHHH
AIAGAGIAMLPDFSVSGEIGNGELVRVLPGWRPVGAFGTRISAVRTFSTHVPRAVRVFVA
HHHCCCEEECCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
YLRESMHGGFLQAS
HHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]