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The map label for this gene is acdA [H]

Identifier: 120612453

GI number: 120612453

Start: 4233642

End: 4234853

Strand: Direct

Name: acdA [H]

Synonym: Aave_3812

Alternate gene names: 120612453

Gene position: 4233642-4234853 (Clockwise)

Preceding gene: 120612452

Following gene: 120612462

Centisome position: 79.09

GC content: 66.91

Gene sequence:

>1212_bases
ATGATCCATCTCAGTACCGACCTCCCAATGCAAGCCTTGCGCCGGCGGCTCTCGGCGATCGGCATGCCGCTGGACGAATT
GACGGCGGCTCTGCAGGAGCATGCGGCGCAAGCCGATCGCACCGGCAAGATTGCGCCCGCGTTCTGGGAGCGGGTGAATG
TGCGCGGACTGAACCTCAATCTCGTGCCTCCGGACCATGGAGGGGACCCCGGCCTGTGGCCCCTGATGCAGCGCGTACTG
CTGATGGAACAGCTCGGCTACGCGGACCCGGCCCTGGCTCTGGCCATGCCCGGTCCAGGGCTCGCCACGCCGCCGTTGCT
GGCCCTGGCGTCCGAATCTCAGCAGCGGGCGCTCTTCGCACGCTTCCAGAAGGATCATCCCGTATGGGGCGGCTTCGCCA
TCACGGAACCCGACATCGGCTCGGATGCCACCGCACTGCGCACCACGGCGCGGCCCGTGCGCGACGGCTACCTGCTCAAC
GGAACCAAGTGCTTCATCACCAATGGCGCCCGGGCGGACTTCGTGGTCACCTTCGCAACCCTGGACAAGGGGCGGGGACG
CTTCGGCGTGCGCGCTTTCGCCGTCGATAGCACGGCGCCCGGATTCGAGGTGGTGCGCCTGGAGAAGATGCTGGGGCTGC
GCGCGAGCCAGCTCGCCGTGCTCTCGTATTCGGATTGCCTGGTTCCACACGACAGCCTGCTGCAGCGGGGAGACGAGGGG
CATATGCACGATGCGTTTTCCGGGGCGCAGAGCTCCTGGGACTTTTTCCGTCCAGTCCTCTCGGCGACCATTGTCGGCAG
TTGCGCCCGGGCGCGGGACGAACTCGCGGCATACCTGGCTGCGCACCAGCCCGCCGCTCCAGGCTGGCGCAGGACCGATA
CCGAGGATCTTCTGGCCGCCGCAGGCGGAAAGATCGCCATGGCCCGCCTGCTATGCCACAAGGCGGCGTGGCGGCACGAG
CAGGGACTTTCGGTATCCAAGGACTCTTCCATGGCGAAAGCGTATGCATCGCGCATCGCCATGGAAATCGCCGAGGCGGT
ACTCCAGGCGGTCGGGGCCCCGGGGCTGCACGAACATCCCGTGCTGGAGCGGTTCTACCGCAATGCCAAGGCCTACGACA
TCCTCGAGGGTACCGGCGACATGCAGCGGCTCATGGTGGCGCGATTGCAGCAGCGGCAAGCTGCCGCCGCGGACGAAACC
GCAGTCTTCTGA

Upstream 100 bases:

>100_bases
AATCCGTTCTCCGCCGCACGCGGACGCAGGCAGGCCTTCTCCACGAAAACGCTTCGCCCCTCCAAAGCGCTCCGTGCGCG
CAGTTCTGAAAGGAAAGACC

Downstream 100 bases:

>100_bases
ACAGCGCGGGCGCCGTCAGGCGCCTTTTCTCGTCCGGGGCGCAGGCGCCCGCATCGGCCGGACCTGCGGCAGAGGTGCTC
CACCCAGGCGCAGGTCGGAA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MIHLSTDLPMQALRRRLSAIGMPLDELTAALQEHAAQADRTGKIAPAFWERVNVRGLNLNLVPPDHGGDPGLWPLMQRVL
LMEQLGYADPALALAMPGPGLATPPLLALASESQQRALFARFQKDHPVWGGFAITEPDIGSDATALRTTARPVRDGYLLN
GTKCFITNGARADFVVTFATLDKGRGRFGVRAFAVDSTAPGFEVVRLEKMLGLRASQLAVLSYSDCLVPHDSLLQRGDEG
HMHDAFSGAQSSWDFFRPVLSATIVGSCARARDELAAYLAAHQPAAPGWRRTDTEDLLAAAGGKIAMARLLCHKAAWRHE
QGLSVSKDSSMAKAYASRIAMEIAEAVLQAVGAPGLHEHPVLERFYRNAKAYDILEGTGDMQRLMVARLQQRQAAAADET
AVF

Sequences:

>Translated_403_residues
MIHLSTDLPMQALRRRLSAIGMPLDELTAALQEHAAQADRTGKIAPAFWERVNVRGLNLNLVPPDHGGDPGLWPLMQRVL
LMEQLGYADPALALAMPGPGLATPPLLALASESQQRALFARFQKDHPVWGGFAITEPDIGSDATALRTTARPVRDGYLLN
GTKCFITNGARADFVVTFATLDKGRGRFGVRAFAVDSTAPGFEVVRLEKMLGLRASQLAVLSYSDCLVPHDSLLQRGDEG
HMHDAFSGAQSSWDFFRPVLSATIVGSCARARDELAAYLAAHQPAAPGWRRTDTEDLLAAAGGKIAMARLLCHKAAWRHE
QGLSVSKDSSMAKAYASRIAMEIAEAVLQAVGAPGLHEHPVLERFYRNAKAYDILEGTGDMQRLMVARLQQRQAAAADET
AVF
>Mature_403_residues
MIHLSTDLPMQALRRRLSAIGMPLDELTAALQEHAAQADRTGKIAPAFWERVNVRGLNLNLVPPDHGGDPGLWPLMQRVL
LMEQLGYADPALALAMPGPGLATPPLLALASESQQRALFARFQKDHPVWGGFAITEPDIGSDATALRTTARPVRDGYLLN
GTKCFITNGARADFVVTFATLDKGRGRFGVRAFAVDSTAPGFEVVRLEKMLGLRASQLAVLSYSDCLVPHDSLLQRGDEG
HMHDAFSGAQSSWDFFRPVLSATIVGSCARARDELAAYLAAHQPAAPGWRRTDTEDLLAAAGGKIAMARLLCHKAAWRHE
QGLSVSKDSSMAKAYASRIAMEIAEAVLQAVGAPGLHEHPVLERFYRNAKAYDILEGTGDMQRLMVARLQQRQAAAADET
AVF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=368, Percent_Identity=30.9782608695652, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI187960098, Length=368, Percent_Identity=30.9782608695652, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI4557233, Length=355, Percent_Identity=32.112676056338, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI226958412, Length=370, Percent_Identity=27.5675675675676, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4501859, Length=353, Percent_Identity=28.328611898017, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI226958414, Length=373, Percent_Identity=26.8096514745308, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI76496475, Length=339, Percent_Identity=25.3687315634218, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4557235, Length=339, Percent_Identity=25.3687315634218, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI4501857, Length=365, Percent_Identity=23.5616438356164, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI7656849, Length=265, Percent_Identity=27.1698113207547, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI21361497, Length=363, Percent_Identity=24.5179063360882, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4503943, Length=317, Percent_Identity=26.1829652996845, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786223, Length=366, Percent_Identity=26.775956284153, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87081958, Length=362, Percent_Identity=24.8618784530387, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=373, Percent_Identity=29.2225201072386, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17534899, Length=363, Percent_Identity=29.2011019283747, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17508101, Length=332, Percent_Identity=29.5180722891566, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17506239, Length=358, Percent_Identity=29.0502793296089, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17570075, Length=367, Percent_Identity=27.2479564032698, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17538396, Length=352, Percent_Identity=27.8409090909091, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71990804, Length=303, Percent_Identity=28.3828382838284, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=26.5027322404372, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71982178, Length=247, Percent_Identity=28.7449392712551, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=390, Percent_Identity=23.5897435897436, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI32563615, Length=234, Percent_Identity=28.2051282051282, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17551932, Length=400, Percent_Identity=23.25, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71985192, Length=241, Percent_Identity=26.9709543568465, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17505929, Length=310, Percent_Identity=25.1612903225806, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24646207, Length=309, Percent_Identity=31.7152103559871, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24660351, Length=358, Percent_Identity=28.7709497206704, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI21356377, Length=328, Percent_Identity=31.7073170731707, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24666513, Length=368, Percent_Identity=28.2608695652174, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21355753, Length=349, Percent_Identity=28.3667621776504, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI281363737, Length=373, Percent_Identity=27.3458445040214, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19920834, Length=293, Percent_Identity=25.938566552901, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43651; Mature: 43651

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHLSTDLPMQALRRRLSAIGMPLDELTAALQEHAAQADRTGKIAPAFWERVNVRGLNLN
CEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEEEEE
LVPPDHGGDPGLWPLMQRVLLMEQLGYADPALALAMPGPGLATPPLLALASESQQRALFA
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHCCHHHHHHHH
RFQKDHPVWGGFAITEPDIGSDATALRTTARPVRDGYLLNGTKCFITNGARADFVVTFAT
HHHCCCCCCCCEEECCCCCCCCHHHHHHHCCHHCCCEEECCEEEEEECCCCCEEEEEEEE
LDKGRGRFGVRAFAVDSTAPGFEVVRLEKMLGLRASQLAVLSYSDCLVPHDSLLQRGDEG
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHEEEEECCCCCCCCHHHHHCCCCC
HMHDAFSGAQSSWDFFRPVLSATIVGSCARARDELAAYLAAHQPAAPGWRRTDTEDLLAA
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AGGKIAMARLLCHKAAWRHEQGLSVSKDSSMAKAYASRIAMEIAEAVLQAVGAPGLHEHP
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
VLERFYRNAKAYDILEGTGDMQRLMVARLQQRQAAAADETAVF
HHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MIHLSTDLPMQALRRRLSAIGMPLDELTAALQEHAAQADRTGKIAPAFWERVNVRGLNLN
CEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEEEEE
LVPPDHGGDPGLWPLMQRVLLMEQLGYADPALALAMPGPGLATPPLLALASESQQRALFA
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHCCHHHHHHHH
RFQKDHPVWGGFAITEPDIGSDATALRTTARPVRDGYLLNGTKCFITNGARADFVVTFAT
HHHCCCCCCCCEEECCCCCCCCHHHHHHHCCHHCCCEEECCEEEEEECCCCCEEEEEEEE
LDKGRGRFGVRAFAVDSTAPGFEVVRLEKMLGLRASQLAVLSYSDCLVPHDSLLQRGDEG
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHEEEEECCCCCCCCHHHHHCCCCC
HMHDAFSGAQSSWDFFRPVLSATIVGSCARARDELAAYLAAHQPAAPGWRRTDTEDLLAA
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AGGKIAMARLLCHKAAWRHEQGLSVSKDSSMAKAYASRIAMEIAEAVLQAVGAPGLHEHP
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
VLERFYRNAKAYDILEGTGDMQRLMVARLQQRQAAAADETAVF
HHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]