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The map label for this gene is phoP [H]

Identifier: 120612421

GI number: 120612421

Start: 4198207

End: 4198881

Strand: Reverse

Name: phoP [H]

Synonym: Aave_3779

Alternate gene names: 120612421

Gene position: 4198881-4198207 (Counterclockwise)

Preceding gene: 120612422

Following gene: 120612420

Centisome position: 78.44

GC content: 70.96

Gene sequence:

>675_bases
ATGCGCGTACTGGTGGTGGAAGACGATGAGGCGCTGGCGCGGCAATTGCGCGAGGCCCTGGAGGCCGCGGGCTTCGCGGT
GGACGTGGAGCACGACGGCGAGGCCGCGTCCTTCGCGGGCAGCGTGGAGGCCTACAGCGCCGCGGTGCTGGACCTGGGCC
TGCCGCTCAAGGACGGCCTGAGCGTGCTGCACGACTGGCGCGAGGCCGGCCGCGGCTGGCCCGTGCTGGTGCTCACCGCC
CGCAACCGCTGGAGCGACAAGCTCGCCGGCTTCAATGCGGGAGCCGACGACTACCTGACCAAGCCGTTCCTGATGGACGA
GGTGGTGCTGCGGCTGCGGGCCATGCTGCGCCGCGCGGCCGGGGCCGCCGCCGCGGTGCTGCGCGCGGGGCCGCTGGAGT
ACGACGCGGTGCAGGGCCGGTTCTCGCTGCACGGGCAGGCACTGCAGCTCACCGCGCAGGAGCACAAGATCCTGGCGTAC
TTCATCCACCACCCGGGCAAACTGCTCACGCGCACCGACATCACCGAGCACGTATATGCGCGCGATCTGGATCCGGACTC
CAATACGCTGGACGTGCTGATCAGCCGCATCCGCCGCAAGCTCGGCGGTGCGCCGCAACTGCTGACCGAGCGTGGCCAGG
GATTCCGGCTCGTGTCTTCCGATGCGCCGGGCTGA

Upstream 100 bases:

>100_bases
ACTACAGTGTCGAACTGCAGCAGCCCAACGGCTTCAAGCTGGAACTGGAAGTGGATGCCGCCACCCTGGAGGTGACGCGG
CAGAAGGTGGACGACGACTG

Downstream 100 bases:

>100_bases
GGCATCGTGGGGCCCGCCATGACGCAGGGCGAAGGCCCCGCCCGGGGGGCGGAAGCCGCGCCGCCGGCTGCTCCGGTGCC
GCCGGCGCGGGGAATGTCCG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRVLVVEDDEALARQLREALEAAGFAVDVEHDGEAASFAGSVEAYSAAVLDLGLPLKDGLSVLHDWREAGRGWPVLVLTA
RNRWSDKLAGFNAGADDYLTKPFLMDEVVLRLRAMLRRAAGAAAAVLRAGPLEYDAVQGRFSLHGQALQLTAQEHKILAY
FIHHPGKLLTRTDITEHVYARDLDPDSNTLDVLISRIRRKLGGAPQLLTERGQGFRLVSSDAPG

Sequences:

>Translated_224_residues
MRVLVVEDDEALARQLREALEAAGFAVDVEHDGEAASFAGSVEAYSAAVLDLGLPLKDGLSVLHDWREAGRGWPVLVLTA
RNRWSDKLAGFNAGADDYLTKPFLMDEVVLRLRAMLRRAAGAAAAVLRAGPLEYDAVQGRFSLHGQALQLTAQEHKILAY
FIHHPGKLLTRTDITEHVYARDLDPDSNTLDVLISRIRRKLGGAPQLLTERGQGFRLVSSDAPG
>Mature_224_residues
MRVLVVEDDEALARQLREALEAAGFAVDVEHDGEAASFAGSVEAYSAAVLDLGLPLKDGLSVLHDWREAGRGWPVLVLTA
RNRWSDKLAGFNAGADDYLTKPFLMDEVVLRLRAMLRRAAGAAAAVLRAGPLEYDAVQGRFSLHGQALQLTAQEHKILAY
FIHHPGKLLTRTDITEHVYARDLDPDSNTLDVLISRIRRKLGGAPQLLTERGQGFRLVSSDAPG

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=38.5321100917431, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=37.7880184331797, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=37.5565610859729, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=33.6283185840708, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=32.8828828828829, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=34.1991341991342, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=33.7837837837838, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=32.8828828828829, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789809, Length=215, Percent_Identity=32.093023255814, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=32.579185520362, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=28.3842794759825, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788394, Length=204, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=30.0448430493274, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24459; Mature: 24459

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVEDDEALARQLREALEAAGFAVDVEHDGEAASFAGSVEAYSAAVLDLGLPLKDGL
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCCHHHHH
SVLHDWREAGRGWPVLVLTARNRWSDKLAGFNAGADDYLTKPFLMDEVVLRLRAMLRRAA
HHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
GAAAAVLRAGPLEYDAVQGRFSLHGQALQLTAQEHKILAYFIHHPGKLLTRTDITEHVYA
HHHHHHHHCCCCCHHHHCCCCEECCCEEEEEHHHCEEEEEEEECCCCCEEHHHHHHHHHH
RDLDPDSNTLDVLISRIRRKLGGAPQLLTERGQGFRLVSSDAPG
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure
MRVLVVEDDEALARQLREALEAAGFAVDVEHDGEAASFAGSVEAYSAAVLDLGLPLKDGL
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCCHHHHH
SVLHDWREAGRGWPVLVLTARNRWSDKLAGFNAGADDYLTKPFLMDEVVLRLRAMLRRAA
HHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
GAAAAVLRAGPLEYDAVQGRFSLHGQALQLTAQEHKILAYFIHHPGKLLTRTDITEHVYA
HHHHHHHHCCCCCHHHHCCCCEECCCEEEEEHHHCEEEEEEEECCCCCEEHHHHHHHHHH
RDLDPDSNTLDVLISRIRRKLGGAPQLLTERGQGFRLVSSDAPG
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA