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The map label for this gene is phoQ [H]

Identifier: 120612420

GI number: 120612420

Start: 4196689

End: 4198077

Strand: Reverse

Name: phoQ [H]

Synonym: Aave_3778

Alternate gene names: 120612420

Gene position: 4198077-4196689 (Counterclockwise)

Preceding gene: 120612421

Following gene: 120612415

Centisome position: 78.43

GC content: 74.01

Gene sequence:

>1389_bases
ATGGCCACGCGCATCGCATTGCTGGTGCTGATCCCCATGCTGCTGCTGGTGTGCGCGGGCGGGTCGTGGCTGCGCGGCCA
GATGCACCGCAGCCTGATGGACAGCTTCGAGCAGGTGCTGCGGGACAAGGCCCAGCGCGTGGGGGCGCGACTGCAACTGG
GCCCCGGCGGCACGCTCCGCGAGGCTGCGGGCGGGGCGGACGAATTCAGCGCCATCTATGCCGGCTGGTACTGGCGGGCC
GAGGCGGGCCGCGAAGTGCTGCGCTCGCGCTCGCTGTGGGACATGGACCGCCTGCCCACCGATGACCGTCCCGCGGCCGG
ATCGGCCGTGCTGCACCCCGCCACGGGCCCCCGGCAGGAGCCGCTGCTGGCGCTCACGGTGCCCGTCGCCCTGGGCCAGC
CTGCCGCTGCGGTGGCGCTGACGGTGTTCGGCCCGGCGGAGCAGTTGCAGAGCAGCGTGCGACAGATCGACCGCAACCTC
GTGCTGGCCGGTTCGGTGCTTCTGGCCCTGGCCGGCGTGCTGGCCTGGCTGCAGGTGCGCGTGGGGCTGGCGCCGCTGCG
CCGGCTGGAAGCGCTGCTCGCAACGCTGCGGGAGCCGCAGGGCGCCGGGGCCGGCGTGGCGGAACACCTGGCGGCCCCCA
CGGGGCGGGATCTGCAGCCGCTGCAGAACGAACTGGCCGGATTGCTGGCGCACAACGCGCACGTGGTGGCCCGCGCGCGG
GCCCATGCGGTGGACCTGAACCATGCCCTCAAGAAGCCCCTGGCGCTGCTGAACGCGCAGGCCAGCGCGCAGCCGCAGGT
GGCCAGCAGCGAAGTGCGCCGCCAGGTGGAGGCCATGGCGCAACTCGTGGACCGCTACCAGGGACGCACGTTGAGCGATG
CCCTGCATGCCCATCCCGGCGCGGGTGCGTCGGCGGTCGATGTGCGCGAGTGCGTGGCCCAGGTGCTGCGGATGATGCAG
CGCCTGCATGCCGCGCAGGAGCTGGACTGGACGCTGGAGGACCGCGCCACGGGCCCGGTGCGGTGGCGCGGGGAGCGCGC
GGACCTGGAGGAGGTGCTGGGCAACCTGCTGGACAACGCCGGCAAATGGGCCGCCTCCCGGGTGCGGCTCACGCTGTCGG
CCGAACCCGCCGCCGGGCTCGGCCGCCTGGAACTGGACGTGGAGGACGACGGTCCCGGCATGACGCCGGAACAATTGCAG
GCCGCGGGCCAGCGCGGTGTGCGGTTCGACGAGTCCATCCAGGGCAGCGGCCTGGGGCTGGCGATCACGGGCCAGATCGC
GCAGGCCTATGGCGGCCGGCTGGCGCTCTATCACAGCGCTGACCTCCGGGGGCTGGGCGTGCGGCTGGAAATGCGGGGCC
TGATCCCGCCCGGGGCCGGGGCCCGCTAG

Upstream 100 bases:

>100_bases
CGAAGGCCCCGCCCGGGGGGCGGAAGCCGCGCCGCCGGCTGCTCCGGTGCCGCCGGCGCGGGGAATGTCCGCATGGGCGC
TGCGGGTCGCCCAGTGGCCC

Downstream 100 bases:

>100_bases
CCGGCAGGCCAGCGGGCCGTTGCGGTGCGCTGGCGTCCCGGCTGCAGCAGCACGACCAGCGCGCCGGCGCCTCCTTCCGC
GGGGCGTGCCTGCACGAAGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MATRIALLVLIPMLLLVCAGGSWLRGQMHRSLMDSFEQVLRDKAQRVGARLQLGPGGTLREAAGGADEFSAIYAGWYWRA
EAGREVLRSRSLWDMDRLPTDDRPAAGSAVLHPATGPRQEPLLALTVPVALGQPAAAVALTVFGPAEQLQSSVRQIDRNL
VLAGSVLLALAGVLAWLQVRVGLAPLRRLEALLATLREPQGAGAGVAEHLAAPTGRDLQPLQNELAGLLAHNAHVVARAR
AHAVDLNHALKKPLALLNAQASAQPQVASSEVRRQVEAMAQLVDRYQGRTLSDALHAHPGAGASAVDVRECVAQVLRMMQ
RLHAAQELDWTLEDRATGPVRWRGERADLEEVLGNLLDNAGKWAASRVRLTLSAEPAAGLGRLELDVEDDGPGMTPEQLQ
AAGQRGVRFDESIQGSGLGLAITGQIAQAYGGRLALYHSADLRGLGVRLEMRGLIPPGAGAR

Sequences:

>Translated_462_residues
MATRIALLVLIPMLLLVCAGGSWLRGQMHRSLMDSFEQVLRDKAQRVGARLQLGPGGTLREAAGGADEFSAIYAGWYWRA
EAGREVLRSRSLWDMDRLPTDDRPAAGSAVLHPATGPRQEPLLALTVPVALGQPAAAVALTVFGPAEQLQSSVRQIDRNL
VLAGSVLLALAGVLAWLQVRVGLAPLRRLEALLATLREPQGAGAGVAEHLAAPTGRDLQPLQNELAGLLAHNAHVVARAR
AHAVDLNHALKKPLALLNAQASAQPQVASSEVRRQVEAMAQLVDRYQGRTLSDALHAHPGAGASAVDVRECVAQVLRMMQ
RLHAAQELDWTLEDRATGPVRWRGERADLEEVLGNLLDNAGKWAASRVRLTLSAEPAAGLGRLELDVEDDGPGMTPEQLQ
AAGQRGVRFDESIQGSGLGLAITGQIAQAYGGRLALYHSADLRGLGVRLEMRGLIPPGAGAR
>Mature_461_residues
ATRIALLVLIPMLLLVCAGGSWLRGQMHRSLMDSFEQVLRDKAQRVGARLQLGPGGTLREAAGGADEFSAIYAGWYWRAE
AGREVLRSRSLWDMDRLPTDDRPAAGSAVLHPATGPRQEPLLALTVPVALGQPAAAVALTVFGPAEQLQSSVRQIDRNLV
LAGSVLLALAGVLAWLQVRVGLAPLRRLEALLATLREPQGAGAGVAEHLAAPTGRDLQPLQNELAGLLAHNAHVVARARA
HAVDLNHALKKPLALLNAQASAQPQVASSEVRRQVEAMAQLVDRYQGRTLSDALHAHPGAGASAVDVRECVAQVLRMMQR
LHAAQELDWTLEDRATGPVRWRGERADLEEVLGNLLDNAGKWAASRVRLTLSAEPAAGLGRLELDVEDDGPGMTPEQLQA
AGQRGVRFDESIQGSGLGLAITGQIAQAYGGRLALYHSADLRGLGVRLEMRGLIPPGAGAR

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=342, Percent_Identity=27.1929824561404, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=288, Percent_Identity=28.4722222222222, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49184; Mature: 49053

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRIALLVLIPMLLLVCAGGSWLRGQMHRSLMDSFEQVLRDKAQRVGARLQLGPGGTLR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHH
EAAGGADEFSAIYAGWYWRAEAGREVLRSRSLWDMDRLPTDDRPAAGSAVLHPATGPRQE
HHCCCHHHHHHHHHHHEEEHHHHHHHHHHCCCCCHHCCCCCCCCCCCCEEECCCCCCCCC
PLLALTVPVALGQPAAAVALTVFGPAEQLQSSVRQIDRNLVLAGSVLLALAGVLAWLQVR
CEEEEEECHHCCCCHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLAPLRRLEALLATLREPQGAGAGVAEHLAAPTGRDLQPLQNELAGLLAHNAHVVARAR
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
AHAVDLNHALKKPLALLNAQASAQPQVASSEVRRQVEAMAQLVDRYQGRTLSDALHAHPG
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
AGASAVDVRECVAQVLRMMQRLHAAQELDWTLEDRATGPVRWRGERADLEEVLGNLLDNA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEECCCCCCHHHHHHHHHHCC
GKWAASRVRLTLSAEPAAGLGRLELDVEDDGPGMTPEQLQAAGQRGVRFDESIQGSGLGL
CCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEE
AITGQIAQAYGGRLALYHSADLRGLGVRLEMRGLIPPGAGAR
EEEHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
ATRIALLVLIPMLLLVCAGGSWLRGQMHRSLMDSFEQVLRDKAQRVGARLQLGPGGTLR
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHH
EAAGGADEFSAIYAGWYWRAEAGREVLRSRSLWDMDRLPTDDRPAAGSAVLHPATGPRQE
HHCCCHHHHHHHHHHHEEEHHHHHHHHHHCCCCCHHCCCCCCCCCCCCEEECCCCCCCCC
PLLALTVPVALGQPAAAVALTVFGPAEQLQSSVRQIDRNLVLAGSVLLALAGVLAWLQVR
CEEEEEECHHCCCCHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLAPLRRLEALLATLREPQGAGAGVAEHLAAPTGRDLQPLQNELAGLLAHNAHVVARAR
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
AHAVDLNHALKKPLALLNAQASAQPQVASSEVRRQVEAMAQLVDRYQGRTLSDALHAHPG
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
AGASAVDVRECVAQVLRMMQRLHAAQELDWTLEDRATGPVRWRGERADLEEVLGNLLDNA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEECCCCCCHHHHHHHHHHCC
GKWAASRVRLTLSAEPAAGLGRLELDVEDDGPGMTPEQLQAAGQRGVRFDESIQGSGLGL
CCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEE
AITGQIAQAYGGRLALYHSADLRGLGVRLEMRGLIPPGAGAR
EEEHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]