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The map label for this gene is fkpB [H]

Identifier: 120612415

GI number: 120612415

Start: 4192705

End: 4193172

Strand: Reverse

Name: fkpB [H]

Synonym: Aave_3772

Alternate gene names: 120612415

Gene position: 4193172-4192705 (Counterclockwise)

Preceding gene: 120612420

Following gene: 120612414

Centisome position: 78.34

GC content: 69.44

Gene sequence:

>468_bases
ATGATTTCCAACGCTTTCCCTTCCGTGCCCACCGTGCAGCCCGGATCCTTCCTGACCCTGCACTACCGCCTGGCAGGCCC
TTCGGGCGATGTCATCAACACGTTCGGCGACAAGCCGGCCACGCTGTCCCTGGGGGCCGGCGAGCTCTCGCCCGCGATGG
AGCAGCGCCTGATCGGCCTCGCGGAAGGCACCCGCGCCACCTTCGAGCTGCCGGCCGGCGAGGCCTTCGGCGAGCGCAAC
CCCGAGATGCAGCAATGGGTGGCGCGCCGGCTGCTGGCCGAACTGGGCGATCCCGACGAGCAGTACACCCTGGGCGACGT
GGTGCAGTTTCCCACGCCCGACGGCACCGGCAGCTATGCCGGCGTGGTGCTGGAGGTGCGGGGGGACGGCGCCGTGCGCT
TCGACTTCAACCATCCGCTCGCGGGCCAGCCCGTCGTCTTCGAGGTGCAACTCATCGGAGTGCTCTGA

Upstream 100 bases:

>100_bases
CAGAAGGAAGGACAATCGGGGCAGACACCGTGACCGCGGATGGGCGGCATGGATACTGGGTTTTTATACACCATCCGCAA
GCTGACAGGCGCTTTTGTCC

Downstream 100 bases:

>100_bases
CGCCATGGCCATCCAACCCCAGGAAATCGTTCTCGCCGAGCCCCGCGGCTTCTGCGCGGGCGTGGACCGCGCGATCGAGA
TCGTCGAGCGGGCCCTGCAG

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MISNAFPSVPTVQPGSFLTLHYRLAGPSGDVINTFGDKPATLSLGAGELSPAMEQRLIGLAEGTRATFELPAGEAFGERN
PEMQQWVARRLLAELGDPDEQYTLGDVVQFPTPDGTGSYAGVVLEVRGDGAVRFDFNHPLAGQPVVFEVQLIGVL

Sequences:

>Translated_155_residues
MISNAFPSVPTVQPGSFLTLHYRLAGPSGDVINTFGDKPATLSLGAGELSPAMEQRLIGLAEGTRATFELPAGEAFGERN
PEMQQWVARRLLAELGDPDEQYTLGDVVQFPTPDGTGSYAGVVLEVRGDGAVRFDFNHPLAGQPVVFEVQLIGVL
>Mature_155_residues
MISNAFPSVPTVQPGSFLTLHYRLAGPSGDVINTFGDKPATLSLGAGELSPAMEQRLIGLAEGTRATFELPAGEAFGERN
PEMQQWVARRLLAELGDPDEQYTLGDVVQFPTPDGTGSYAGVVLEVRGDGAVRFDFNHPLAGQPVVFEVQLIGVL

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=146, Percent_Identity=34.9315068493151, Blast_Score=87, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16512; Mature: 16512

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISNAFPSVPTVQPGSFLTLHYRLAGPSGDVINTFGDKPATLSLGAGELSPAMEQRLIGL
CCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHCC
AEGTRATFELPAGEAFGERNPEMQQWVARRLLAELGDPDEQYTLGDVVQFPTPDGTGSYA
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCEEECCCCCCCCCEE
GVVLEVRGDGAVRFDFNHPLAGQPVVFEVQLIGVL
EEEEEECCCCEEEEECCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MISNAFPSVPTVQPGSFLTLHYRLAGPSGDVINTFGDKPATLSLGAGELSPAMEQRLIGL
CCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHCC
AEGTRATFELPAGEAFGERNPEMQQWVARRLLAELGDPDEQYTLGDVVQFPTPDGTGSYA
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCEEECCCCCCCCCEE
GVVLEVRGDGAVRFDFNHPLAGQPVVFEVQLIGVL
EEEEEECCCCEEEEECCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]