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The map label for this gene is serS

Identifier: 120612410

GI number: 120612410

Start: 4187093

End: 4188412

Strand: Reverse

Name: serS

Synonym: Aave_3767

Alternate gene names: 120612410

Gene position: 4188412-4187093 (Counterclockwise)

Preceding gene: 120612411

Following gene: 120612409

Centisome position: 78.25

GC content: 68.79

Gene sequence:

>1320_bases
ATGCTCGACATCCTCCTCCTCCGCAAAGACCTCGATTCCGCCATCGCGCGGCTGGAAACCCGCAAGAAGCCCCAGGCTTT
CCTCCAGGTGGAGGCCTTCCAGTCCCTCGAGTCCGAGCGCAAGACGCTGCAGACGCGCACCGAGGAACTGCAGTCGCGCC
GCAACCAGCTCTCCAAGCAGGTCGGCCAGCTCAAGGCCAGGGGCGAGAACGCCGATGCCGTGATGGCCGAAGTGGGCGGC
CTGAAGGCCGAGCTGGAGAATTCCGCCGCCCGCCTGGAGCAGATCCAGGCCGAGCTGCACACGCTGCTCGTGGCCGTGCC
CAACCTGCCGCACGAGAGCGTGCCCGTGGGCAGCGACGAATCCGGCAACGTGGAAGTGCGCCGCTGGAGCCCGGACGGGC
AGGATCCGAAGCCGCTCGGCTTCCCCGCGAAAGACCATGTGGACCTGGGCGAGCCCCTGGGCCTGGATTTCGACATGGGC
GTGAAGCTCTCGGGCTCGCGCTTCACCGTGATGAAGGGGCCGATCGCCCGCCTGCACCGCGCGCTCGCCCAGTTCATGCT
GGACGTGCAGACGCGCGAGCACGGCTACACCGAGTGCTACGTGCCCTACGTGGTGAACGCCGACTCGCTGCGCGGCACGG
GCCAGCTGCCCAAGTTCGAGGGCGACCTGTTCGCCGCGAAGAAGGGCGGCCAGGACGGCGAGCCCGTGCCCGACAACGCG
GCGCTCTACCTGATCCCGACCAGCGAGGTGCCGCTCACGAACTTCGTGCGCGACCAGGTCGTGCCCGAATCCGAACTGCC
CATCCGCCTCACGGCCCACACCCCGTGCTTCCGCTCCGAGGCCGGCAGCTACGGCCGCGACACGCGCGGCATGATCCGCC
AGCACCAGTTCGACAAGGTCGAGATGGTGCAGATCACCCACCCGGACCGCAGCTACGAGGCCCTGGAAGAGATGACCGGC
CACGCCGAGGCCGTGCTGCAGAAGCTCGGCCTGCCGTACCGCGTCATGTCGCTCTGCACGGGCGACATGGGCTTCGGCGC
CGCCAAGACCTACGACCTGGAAGTGTGGCTGCCCGCGCAGAACACCTACCGCGAGATCAGCTCCGTGAGCAACTGCGAGG
CCTTCCAGGCGCGCCGCCTGCAGGCGCGCTTCAAGAACGCCCAGGGCAAGAACGAACTCGTGCACACCCTGAACGGCTCG
GGCCTCGCCGTGGGCCGCACGCTGGTGGCGGTGCTGGAGAACTACCAGCAGGCCGACGGCAGCGTGGCGGTGCCGGAAGC
CCTGCGGCCGTACCTGGGTGGGGACAGCGTCCTGCGGTAA

Upstream 100 bases:

>100_bases
ACCGTGGGCCTGGTGCTCTGCGGCGCCAACTGCGACCCGGCCACCGTGGCCTGAGAACCCGGGCCCGCCGGGCGGGGGCG
GGGCCGTAAAATCGCCGGCT

Downstream 100 bases:

>100_bases
ACCGCGTCGCCCGGCGGGCGCGAAGGCGATGGTTTAATGCGATGCTGATCCCGGCCCGCTCTCTGGCAACACACCCATGC
GCAGCATCTTCCACCTGGCC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLDILLLRKDLDSAIARLETRKKPQAFLQVEAFQSLESERKTLQTRTEELQSRRNQLSKQVGQLKARGENADAVMAEVGG
LKAELENSAARLEQIQAELHTLLVAVPNLPHESVPVGSDESGNVEVRRWSPDGQDPKPLGFPAKDHVDLGEPLGLDFDMG
VKLSGSRFTVMKGPIARLHRALAQFMLDVQTREHGYTECYVPYVVNADSLRGTGQLPKFEGDLFAAKKGGQDGEPVPDNA
ALYLIPTSEVPLTNFVRDQVVPESELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQITHPDRSYEALEEMTG
HAEAVLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNTYREISSVSNCEAFQARRLQARFKNAQGKNELVHTLNGS
GLAVGRTLVAVLENYQQADGSVAVPEALRPYLGGDSVLR

Sequences:

>Translated_439_residues
MLDILLLRKDLDSAIARLETRKKPQAFLQVEAFQSLESERKTLQTRTEELQSRRNQLSKQVGQLKARGENADAVMAEVGG
LKAELENSAARLEQIQAELHTLLVAVPNLPHESVPVGSDESGNVEVRRWSPDGQDPKPLGFPAKDHVDLGEPLGLDFDMG
VKLSGSRFTVMKGPIARLHRALAQFMLDVQTREHGYTECYVPYVVNADSLRGTGQLPKFEGDLFAAKKGGQDGEPVPDNA
ALYLIPTSEVPLTNFVRDQVVPESELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQITHPDRSYEALEEMTG
HAEAVLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNTYREISSVSNCEAFQARRLQARFKNAQGKNELVHTLNGS
GLAVGRTLVAVLENYQQADGSVAVPEALRPYLGGDSVLR
>Mature_439_residues
MLDILLLRKDLDSAIARLETRKKPQAFLQVEAFQSLESERKTLQTRTEELQSRRNQLSKQVGQLKARGENADAVMAEVGG
LKAELENSAARLEQIQAELHTLLVAVPNLPHESVPVGSDESGNVEVRRWSPDGQDPKPLGFPAKDHVDLGEPLGLDFDMG
VKLSGSRFTVMKGPIARLHRALAQFMLDVQTREHGYTECYVPYVVNADSLRGTGQLPKFEGDLFAAKKGGQDGEPVPDNA
ALYLIPTSEVPLTNFVRDQVVPESELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQITHPDRSYEALEEMTG
HAEAVLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNTYREISSVSNCEAFQARRLQARFKNAQGKNELVHTLNGS
GLAVGRTLVAVLENYQQADGSVAVPEALRPYLGGDSVLR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=466, Percent_Identity=32.618025751073, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI8923421, Length=416, Percent_Identity=32.2115384615385, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI225579074, Length=347, Percent_Identity=33.4293948126801, Blast_Score=181, Evalue=2e-45,
Organism=Escherichia coli, GI1787120, Length=437, Percent_Identity=60.6407322654462, Blast_Score=522, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17539260, Length=421, Percent_Identity=32.3040380047506, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17542084, Length=343, Percent_Identity=28.8629737609329, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=410, Percent_Identity=34.1463414634146, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6321799, Length=394, Percent_Identity=28.4263959390863, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24581334, Length=470, Percent_Identity=33.4042553191489, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17737985, Length=353, Percent_Identity=29.7450424929178, Blast_Score=148, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ACIAC (A1TTM6)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972088.1
- ProteinModelPortal:   A1TTM6
- SMR:   A1TTM6
- STRING:   A1TTM6
- GeneID:   4668575
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3767
- NMPDR:   fig|397945.5.peg.3218
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   A1TTM6
- ProtClustDB:   PRK05431
- BioCyc:   AAVE397945:AAVE_3767-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48489; Mature: 48489

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 301-301 BINDING 400-400

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDILLLRKDLDSAIARLETRKKPQAFLQVEAFQSLESERKTLQTRTEELQSRRNQLSKQ
CCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGQLKARGENADAVMAEVGGLKAELENSAARLEQIQAELHTLLVAVPNLPHESVPVGSDE
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SGNVEVRRWSPDGQDPKPLGFPAKDHVDLGEPLGLDFDMGVKLSGSRFTVMKGPIARLHR
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCHHHHHH
ALAQFMLDVQTREHGYTECYVPYVVNADSLRGTGQLPKFEGDLFAAKKGGQDGEPVPDNA
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
ALYLIPTSEVPLTNFVRDQVVPESELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKV
EEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCCE
EMVQITHPDRSYEALEEMTGHAEAVLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQ
EEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEEECCC
NTYREISSVSNCEAFQARRLQARFKNAQGKNELVHTLNGSGLAVGRTLVAVLENYQQADG
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
SVAVPEALRPYLGGDSVLR
CEECHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLDILLLRKDLDSAIARLETRKKPQAFLQVEAFQSLESERKTLQTRTEELQSRRNQLSKQ
CCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGQLKARGENADAVMAEVGGLKAELENSAARLEQIQAELHTLLVAVPNLPHESVPVGSDE
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SGNVEVRRWSPDGQDPKPLGFPAKDHVDLGEPLGLDFDMGVKLSGSRFTVMKGPIARLHR
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCHHHHHH
ALAQFMLDVQTREHGYTECYVPYVVNADSLRGTGQLPKFEGDLFAAKKGGQDGEPVPDNA
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
ALYLIPTSEVPLTNFVRDQVVPESELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKV
EEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCCE
EMVQITHPDRSYEALEEMTGHAEAVLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQ
EEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEEECCC
NTYREISSVSNCEAFQARRLQARFKNAQGKNELVHTLNGSGLAVGRTLVAVLENYQQADG
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
SVAVPEALRPYLGGDSVLR
CEECHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA