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The map label for this gene is lon2 [H]

Identifier: 120612311

GI number: 120612311

Start: 4043481

End: 4044491

Strand: Direct

Name: lon2 [H]

Synonym: Aave_3667

Alternate gene names: 120612311

Gene position: 4043481-4044491 (Clockwise)

Preceding gene: 120612310

Following gene: 120612312

Centisome position: 75.54

GC content: 68.74

Gene sequence:

>1011_bases
ATGACGACGACACACAGCCTTGTCCCGCAATCGCCTTCGATGGGCCTGCCGGTGGCCCAATTGCGCAACGTGTTCCGGCC
CGGCGACGTGGAGCGCAAGCTCGCCCGGCTCCAGGACGCCGGCAGCCAGCGTGAGTACGAAACGCTGCGCGCCGTGTACG
AGCGCATGCTCGAACGCGGGCCCGAACGTTTCCAGGTCAAGCCCTCGGGCGTGCCCGACATGGCCGGGCTCTACGGGCAG
CTTCCCAATTTCACCGATGTGCTCGACGACGTGAAGCGCCACGTCGCCCTCGCGCAGGACAGCCGCGATGGCCTGGAGGT
CACGCCCATGCTGCTGCTGGGCCCTCCCGGCATCGGCAAGACCCACTTCGCGCGCCAGCTGGCCGAATTGCTGGGCACCG
GCATGAACCTCGTGCCCATGAGCTCGATGACGGCCGGATGGCTGCTTTCGGGCTCATCCTCGCAATGGAAGGGCGCGCGC
CCCGGCAAGGTCTTCGAGGCCCTGGTGGACGGCGAATACGCCAACCCCGTCATCGTGGTGGACGAGATCGACAAGGCCGC
CCCCGATGCGCAGTACGACCCCCTGGGCGCCCTCTACGGCCTGCTGGAACACGACACGGCCCAGAGCTTCACCGACGAGT
TCGCGGAAATCGCCATCGACGCCAGCCAGGTGATCTGGATCACCACCGCCAACGACGAGCGCGGCATCCCCGACCCCATC
CTCAACCGCATGAACGTGTTCGAGGTCCAGGCGCCCTCGCCCGAGCAGGCCCGCGCCATCGCGCGCAACCTCTACCAGGG
CATCCGCGAAGGCCATGACTGGGGCCGGCTGATCGACCCCGAACCCCCGGCCGACGTGCTGGACATCCTGGCGCAGATGC
CGCCGCGCGAGATGCGCCGGGCGCTGATGACGGGCTTCGGCAACGCGCGGCTGCAGCACCGCTCCACCGTCGAGGTGTCG
GACCTGCCGCGCGGCGCATCCGGCAAGCCGCGCATGGGTTTCGTCCAGTAG

Upstream 100 bases:

>100_bases
ACTGCTACCGGTTGACGGGGTTTTTCCATCTTTGGAGCCCGGCATGTTGTGTGCTTGAATGGTTGCGTGCCCTTTCACTC
CAACGAACCAGGAGCGCGCC

Downstream 100 bases:

>100_bases
CCGGCCGCTCCTGCGCGGCGCACGGGCGGGGCGGAAGGGGCGCCGCGCGCCGCGTGCCCCGCTGATCCGCCGCGCAAGCC
GGCTGGACTGTTCCGCACGG

Product: ATPase central domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTTTHSLVPQSPSMGLPVAQLRNVFRPGDVERKLARLQDAGSQREYETLRAVYERMLERGPERFQVKPSGVPDMAGLYGQ
LPNFTDVLDDVKRHVALAQDSRDGLEVTPMLLLGPPGIGKTHFARQLAELLGTGMNLVPMSSMTAGWLLSGSSSQWKGAR
PGKVFEALVDGEYANPVIVVDEIDKAAPDAQYDPLGALYGLLEHDTAQSFTDEFAEIAIDASQVIWITTANDERGIPDPI
LNRMNVFEVQAPSPEQARAIARNLYQGIREGHDWGRLIDPEPPADVLDILAQMPPREMRRALMTGFGNARLQHRSTVEVS
DLPRGASGKPRMGFVQ

Sequences:

>Translated_336_residues
MTTTHSLVPQSPSMGLPVAQLRNVFRPGDVERKLARLQDAGSQREYETLRAVYERMLERGPERFQVKPSGVPDMAGLYGQ
LPNFTDVLDDVKRHVALAQDSRDGLEVTPMLLLGPPGIGKTHFARQLAELLGTGMNLVPMSSMTAGWLLSGSSSQWKGAR
PGKVFEALVDGEYANPVIVVDEIDKAAPDAQYDPLGALYGLLEHDTAQSFTDEFAEIAIDASQVIWITTANDERGIPDPI
LNRMNVFEVQAPSPEQARAIARNLYQGIREGHDWGRLIDPEPPADVLDILAQMPPREMRRALMTGFGNARLQHRSTVEVS
DLPRGASGKPRMGFVQ
>Mature_335_residues
TTTHSLVPQSPSMGLPVAQLRNVFRPGDVERKLARLQDAGSQREYETLRAVYERMLERGPERFQVKPSGVPDMAGLYGQL
PNFTDVLDDVKRHVALAQDSRDGLEVTPMLLLGPPGIGKTHFARQLAELLGTGMNLVPMSSMTAGWLLSGSSSQWKGARP
GKVFEALVDGEYANPVIVVDEIDKAAPDAQYDPLGALYGLLEHDTAQSFTDEFAEIAIDASQVIWITTANDERGIPDPIL
NRMNVFEVQAPSPEQARAIARNLYQGIREGHDWGRLIDPEPPADVLDILAQMPPREMRRALMTGFGNARLQHRSTVEVSD
LPRGASGKPRMGFVQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=178, Percent_Identity=32.5842696629214, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI31377667, Length=192, Percent_Identity=30.7291666666667, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786643, Length=153, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17556486, Length=182, Percent_Identity=29.6703296703297, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17505831, Length=153, Percent_Identity=32.0261437908497, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319449, Length=151, Percent_Identity=35.7615894039735, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221513036, Length=178, Percent_Identity=32.5842696629214, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24666867, Length=178, Percent_Identity=32.5842696629214, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 36946; Mature: 36814

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTHSLVPQSPSMGLPVAQLRNVFRPGDVERKLARLQDAGSQREYETLRAVYERMLERG
CCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
PERFQVKPSGVPDMAGLYGQLPNFTDVLDDVKRHVALAQDSRDGLEVTPMLLLGPPGIGK
CCEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECEEEEECCCCCCH
THFARQLAELLGTGMNLVPMSSMTAGWLLSGSSSQWKGARPGKVFEALVDGEYANPVIVV
HHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCEEEE
DEIDKAAPDAQYDPLGALYGLLEHDTAQSFTDEFAEIAIDASQVIWITTANDERGIPDPI
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHH
LNRMNVFEVQAPSPEQARAIARNLYQGIREGHDWGRLIDPEPPADVLDILAQMPPREMRR
HCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHH
ALMTGFGNARLQHRSTVEVSDLPRGASGKPRMGFVQ
HHHHCCCCCEECCCCCEEHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTTHSLVPQSPSMGLPVAQLRNVFRPGDVERKLARLQDAGSQREYETLRAVYERMLERG
CCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
PERFQVKPSGVPDMAGLYGQLPNFTDVLDDVKRHVALAQDSRDGLEVTPMLLLGPPGIGK
CCEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECEEEEECCCCCCH
THFARQLAELLGTGMNLVPMSSMTAGWLLSGSSSQWKGARPGKVFEALVDGEYANPVIVV
HHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCEEEE
DEIDKAAPDAQYDPLGALYGLLEHDTAQSFTDEFAEIAIDASQVIWITTANDERGIPDPI
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHH
LNRMNVFEVQAPSPEQARAIARNLYQGIREGHDWGRLIDPEPPADVLDILAQMPPREMRR
HCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHH
ALMTGFGNARLQHRSTVEVSDLPRGASGKPRMGFVQ
HHHHCCCCCEECCCCCEEHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA