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The map label for this gene is folE [H]

Identifier: 120612277

GI number: 120612277

Start: 4003620

End: 4004423

Strand: Reverse

Name: folE [H]

Synonym: Aave_3631

Alternate gene names: 120612277

Gene position: 4004423-4003620 (Counterclockwise)

Preceding gene: 120612278

Following gene: 120612276

Centisome position: 74.81

GC content: 65.42

Gene sequence:

>804_bases
ATGTGGCCCGTTGGCGCCGCCAGAGCCCGCGAAACCCTTGTCGAGCCGGGGTGGCGCATCGCTGATACCATCGCCTGCAT
GTTCACACACCTCGCCGACGATCCGAACAGCGCTCCCCCGCATGAAGGCGCGCCTGTCTCGGCCAAGATTCGTGAGCGCC
TGCTCGCGGCCCGCAAGCGGTTCCATGCCAACGACAACATCGCCGATTTCCTGGAGCCCGGCGAACTCGAGCAACTGCTC
GACGAGGTCGAGGCCAAGATGCAGGGCGTGCTCGACAGCATGGTCATCGACACGGCCGGCGATCACAACACCCAGGACAC
CGCGCGCCGCGTGGCGAAGATGTACCTGGGCGAGGTGTTCCGGGGCCGCTACGTCAAGCAGCCCGCGATCACCGAGTTCC
CCAATGCCGAGCACCTGAACGAGCTCATGATCGTCGGGCCGATCACCGTGCGCAGCGCCTGCAGCCACCATTTCTGCCCC
GTGATCGGCAAGCTGTGGATCGGCGTGCTGCCCAATGAGCACACCAACGTCATCGGCCTGTCGAAGTACGCGCGCCTGGT
GGACTGGGTCATGGGGCGCCCGCAGATCCAGGAGGAGGCCGTGGTGCAACTGGCCGACCTCATCATGGAAAAGACCCAGC
CCGACGGCCTCGCGATCGTGATGGAGGCCAGCCACTTCTGCATGTCCTGGCGGGGCGTGCGCGAGATGGACAGCAAAATG
CTGAACTCGGTGATGCGCGGCGTGTTCCTGAAGGACGCCGCGCTGCGCCGCGAATTCCTCTCGCTCATCCCCGGAAGGAC
CTGA

Upstream 100 bases:

>100_bases
GGGTGGCGTTCGCGCTCATGCGCCTCGCTCTGTGGGTGACCGGCAGCCGGTACTGAGGCGGCCCTGCCTATCGGGCGTTT
GCTATTGATTTGGTAGCTCG

Downstream 100 bases:

>100_bases
CATGCTCGTACGCCTGCTCTATGCGAGCCGCGCGGTGGATACCTCCAGCGCGGCCATCGAAGACATCCTGGCCCAGTCGC
GCCAGCACAACCCCGGCAGC

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MWPVGAARARETLVEPGWRIADTIACMFTHLADDPNSAPPHEGAPVSAKIRERLLAARKRFHANDNIADFLEPGELEQLL
DEVEAKMQGVLDSMVIDTAGDHNTQDTARRVAKMYLGEVFRGRYVKQPAITEFPNAEHLNELMIVGPITVRSACSHHFCP
VIGKLWIGVLPNEHTNVIGLSKYARLVDWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKM
LNSVMRGVFLKDAALRREFLSLIPGRT

Sequences:

>Translated_267_residues
MWPVGAARARETLVEPGWRIADTIACMFTHLADDPNSAPPHEGAPVSAKIRERLLAARKRFHANDNIADFLEPGELEQLL
DEVEAKMQGVLDSMVIDTAGDHNTQDTARRVAKMYLGEVFRGRYVKQPAITEFPNAEHLNELMIVGPITVRSACSHHFCP
VIGKLWIGVLPNEHTNVIGLSKYARLVDWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKM
LNSVMRGVFLKDAALRREFLSLIPGRT
>Mature_267_residues
MWPVGAARARETLVEPGWRIADTIACMFTHLADDPNSAPPHEGAPVSAKIRERLLAARKRFHANDNIADFLEPGELEQLL
DEVEAKMQGVLDSMVIDTAGDHNTQDTARRVAKMYLGEVFRGRYVKQPAITEFPNAEHLNELMIVGPITVRSACSHHFCP
VIGKLWIGVLPNEHTNVIGLSKYARLVDWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKM
LNSVMRGVFLKDAALRREFLSLIPGRT

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=127, Percent_Identity=46.4566929133858, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4503949, Length=127, Percent_Identity=46.4566929133858, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI66932970, Length=102, Percent_Identity=39.2156862745098, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI66932972, Length=88, Percent_Identity=43.1818181818182, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI1788476, Length=179, Percent_Identity=32.4022346368715, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560486, Length=130, Percent_Identity=43.8461538461538, Blast_Score=114, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321706, Length=188, Percent_Identity=36.1702127659575, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24656791, Length=127, Percent_Identity=41.7322834645669, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24656782, Length=130, Percent_Identity=40.7692307692308, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24656796, Length=130, Percent_Identity=40.7692307692308, Blast_Score=95, Evalue=4e-20,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 29892; Mature: 29892

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPVGAARARETLVEPGWRIADTIACMFTHLADDPNSAPPHEGAPVSAKIRERLLAARKR
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
FHANDNIADFLEPGELEQLLDEVEAKMQGVLDSMVIDTAGDHNTQDTARRVAKMYLGEVF
HCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
RGRYVKQPAITEFPNAEHLNELMIVGPITVRSACSHHFCPVIGKLWIGVLPNEHTNVIGL
HCCCCCCCCCCCCCCHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHH
SKYARLVDWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
LNSVMRGVFLKDAALRREFLSLIPGRT
HHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MWPVGAARARETLVEPGWRIADTIACMFTHLADDPNSAPPHEGAPVSAKIRERLLAARKR
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
FHANDNIADFLEPGELEQLLDEVEAKMQGVLDSMVIDTAGDHNTQDTARRVAKMYLGEVF
HCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
RGRYVKQPAITEFPNAEHLNELMIVGPITVRSACSHHFCPVIGKLWIGVLPNEHTNVIGL
HCCCCCCCCCCCCCCHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHH
SKYARLVDWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
LNSVMRGVFLKDAALRREFLSLIPGRT
HHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA