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The map label for this gene is gmk [H]

Identifier: 120612230

GI number: 120612230

Start: 3954380

End: 3955000

Strand: Direct

Name: gmk [H]

Synonym: Aave_3583

Alternate gene names: 120612230

Gene position: 3954380-3955000 (Clockwise)

Preceding gene: 120612229

Following gene: 120612231

Centisome position: 73.88

GC content: 65.06

Gene sequence:

>621_bases
ATGGACTATCCCGGAAATCTCTTCGTAGTGGCGGCGCCGAGCGGCGCAGGCAAGTCGAGCCTGGTCAAGGCCCTGCTCGA
ACTCGACTCCCACGTGCAGCCCTCCGTCTCCCACACCACGCGCCCGCCGCGCGGCCAGGAGCGGCACGGGCGCGAGTACT
TCTTCACCTCGGAGCAGGAGTTCGACGCGATGGTCGCCGCCAACGGCTTCATCGAGTGGGCGCACGTGCACGGGCGCCGC
TACGGCACCTCCCGCAAGGGCATCGAGGAACGCATCGGCCAGGGCGCGGACGTGATCCTCGAGATCGACTTCCAGGGAGC
CATGCAGGTGAAGGAAGCCTTCTCCAACGCCGTGCTCATCTTCATCCTGCCGCCGAGCTGGGAAGAGCTGCGCTCGCGGC
TGGAGCGCCGCGGCGAGGACGCTCCCGAGGTGATCGAGCTGCGGCTCAAGAATGCGGCCGTCGAAATGGCGCAGGCCGCC
AAATTCGACTTCGTTATAATCAACGAGCTTTTCGAACGGGCGCTTTTCGACATGAAAACCGTTGTTCACGCCCAGCGGCT
CAAGTACGCAGCCCAGCGCCGGGCCCGGGCCGACACCTTCGAATCCCTCAATATCGTCTAG

Upstream 100 bases:

>100_bases
GTGGACATGAAAGTGCTCATCGAGCAGATGCGCGAGCAGGTCCAGAACATCGAGTGAGCGATAATTCTCCTGTTTTGATA
GCGGCCCGCGCACATCCCGT

Downstream 100 bases:

>100_bases
ACCGCCAGGAGAATCCGCATGGCACGCATCACCGTTGAAGACTGCCTCGAGCACATCCCGAACCGTTTCCAGCTCGTCCT
GGCAGCCACGTACCGCGCGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MDYPGNLFVVAAPSGAGKSSLVKALLELDSHVQPSVSHTTRPPRGQERHGREYFFTSEQEFDAMVAANGFIEWAHVHGRR
YGTSRKGIEERIGQGADVILEIDFQGAMQVKEAFSNAVLIFILPPSWEELRSRLERRGEDAPEVIELRLKNAAVEMAQAA
KFDFVIINELFERALFDMKTVVHAQRLKYAAQRRARADTFESLNIV

Sequences:

>Translated_206_residues
MDYPGNLFVVAAPSGAGKSSLVKALLELDSHVQPSVSHTTRPPRGQERHGREYFFTSEQEFDAMVAANGFIEWAHVHGRR
YGTSRKGIEERIGQGADVILEIDFQGAMQVKEAFSNAVLIFILPPSWEELRSRLERRGEDAPEVIELRLKNAAVEMAQAA
KFDFVIINELFERALFDMKTVVHAQRLKYAAQRRARADTFESLNIV
>Mature_206_residues
MDYPGNLFVVAAPSGAGKSSLVKALLELDSHVQPSVSHTTRPPRGQERHGREYFFTSEQEFDAMVAANGFIEWAHVHGRR
YGTSRKGIEERIGQGADVILEIDFQGAMQVKEAFSNAVLIFILPPSWEELRSRLERRGEDAPEVIELRLKNAAVEMAQAA
KFDFVIINELFERALFDMKTVVHAQRLKYAAQRRARADTFESLNIV

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=36, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=36, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=36, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI38570142, Length=171, Percent_Identity=32.1637426900585, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI14780902, Length=179, Percent_Identity=26.2569832402235, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4505237, Length=170, Percent_Identity=28.8235294117647, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118263, Length=170, Percent_Identity=28.8235294117647, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118255, Length=170, Percent_Identity=28.8235294117647, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118259, Length=174, Percent_Identity=28.1609195402299, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI111154074, Length=172, Percent_Identity=29.6511627906977, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI21361598, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI52630447, Length=189, Percent_Identity=26.4550264550265, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=48.4375, Blast_Score=188, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=38.0681818181818, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=38.0681818181818, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=40.6593406593407, Blast_Score=129, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21356141, Length=158, Percent_Identity=43.0379746835443, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161077626, Length=168, Percent_Identity=27.3809523809524, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221330166, Length=135, Percent_Identity=30.3703703703704, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI221330162, Length=135, Percent_Identity=30.3703703703704, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330164, Length=135, Percent_Identity=30.3703703703704, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554489, Length=173, Percent_Identity=26.5895953757225, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI116007136, Length=173, Percent_Identity=26.5895953757225, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45554481, Length=173, Percent_Identity=26.5895953757225, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24640542, Length=173, Percent_Identity=26.5895953757225, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI85724806, Length=173, Percent_Identity=26.5895953757225, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23246; Mature: 23246

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYPGNLFVVAAPSGAGKSSLVKALLELDSHVQPSVSHTTRPPRGQERHGREYFFTSEQE
CCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCHH
FDAMVAANGFIEWAHVHGRRYGTSRKGIEERIGQGADVILEIDFQGAMQVKEAFSNAVLI
HHHHHHHCCCEEEHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHCCEEEE
FILPPSWEELRSRLERRGEDAPEVIELRLKNAAVEMAQAAKFDFVIINELFERALFDMKT
EEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VVHAQRLKYAAQRRARADTFESLNIV
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDYPGNLFVVAAPSGAGKSSLVKALLELDSHVQPSVSHTTRPPRGQERHGREYFFTSEQE
CCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCHH
FDAMVAANGFIEWAHVHGRRYGTSRKGIEERIGQGADVILEIDFQGAMQVKEAFSNAVLI
HHHHHHHCCCEEEHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHCCEEEE
FILPPSWEELRSRLERRGEDAPEVIELRLKNAAVEMAQAAKFDFVIINELFERALFDMKT
EEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VVHAQRLKYAAQRRARADTFESLNIV
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA