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The map label for this gene is siaT [H]

Identifier: 120612098

GI number: 120612098

Start: 3806160

End: 3807443

Strand: Reverse

Name: siaT [H]

Synonym: Aave_3445

Alternate gene names: 120612098

Gene position: 3807443-3806160 (Counterclockwise)

Preceding gene: 120612099

Following gene: 120612097

Centisome position: 71.13

GC content: 68.69

Gene sequence:

>1284_bases
ATGGCCATCACCCTCTTCGTTTCCGCCCTCCTGCTGATGGCGCTGGGCTTTCCCGTCGCGTTCGCGCTCGCCATGTCGGC
CGCCATCGCGGTCTTCGTGGGCGGGCGCTATCCGCAACTGATCGTGTTCAAGGAGATGTTCACGGGCATCGACAGCTTCC
CGCTGATGGCCGTGCCCTTCTTCATCCTCGCGGCCGAGATCATGTCCGGCGGCGCGCTCACCGTGGTGCTGCTGCGCTTC
GCCGCGCAGTTCGTGGGCCACCTGCGCGGGGGCCTGGGGCACGCCAACATCCTGTCGCTCACGCTGTTCTCGGGCATCTC
GGGCTCGGCCCTGGCCGACGCGGCGGGGCCCGGCTCGATGATGGTCAAGATGATGGACAAGGCGGGCTACTCGCGCGCCT
ACGCCGCCGCGCTCACCGCCAGCACGGCCATCGTGGGGCCCATCATCCCGCCCTCGATCATCATGATCATCTACGCGCTG
CAGGACGAGCAGGTCTCGGTCGGCGCGCTCTTCATCGCCGGCTTCGCGCCGGGCATCCTCATCGCCGTGGCCATGGCCAT
CGTCAACTGGCGCGTGTGCGTGCAGCGCGACTACCGCTCCCGCGAGCCGCGCCCGGGCGGCCGGGAAATGCTCGCCAACA
GCATCCGCGCCATTCCGGCCCTGATGCTGGTGGTGCTGATCCTGGTGGGCATCCGCTTCGGCATCTTCACGCCCACCGAG
GCCTCCGTGGTGGCCGTGTTCTACGCCCTGGTCTGCGGCAAGTGGATCTACCGCACGCTGGAGTGGAAGGCCCTGCCGCA
CATCGCCGCACGCTCCGCGCTGCTCACCGCCTCGGTGCTGCTGGTGGTGGCGGCCTCGGCCGCCTTCGCCTGGGTGCTGA
CGGTGGAAGGGGTGCCCCAGCGCCTGGCCGAGACGATCGTGGGCTGGAACCTCTCGCCCGTCACCTTCCTCATCGCGGTC
AACATCCTGCTGCTGCTCTTCGGCATCTTCATGGAGCCGCTGCCGGGCGTGATGATCCTCGTGCCCATCCTCGCGCCCAT
CTCGGCGGCGCTGGGCATCGACCCGATCCACTTCGCCATGGTGGTGATCGTCAACCTCACCCTGGGCATGATCACGCCGC
CGGTGGGCGGACTGCTGTTCGTCACCTCGGTCGCCACCAAGGTGCCGCTGGCGGCGCTCACGCGCGAACTGCCGCCGTTC
CTCGTGGCGCACCTGATCGTGCTGGGCCTGCTCACCTTCGTGCCCGCCATCTCCACCTGGCTGCCGCACGCACTGGGCTT
CTGA

Upstream 100 bases:

>100_bases
GCGCGGCTACATCCGGGACGGCCGCTACGTCGAATCCGACGAGATGGACGCCGAATCGGCGGCCTCCCTGTGATGGCCCG
CAGCAGAAGGAACTGACGCC

Downstream 100 bases:

>100_bases
GAGGGCGGTACCCCGGCACGTTGTAGAAATGCCGTCATCTTTGATGAACGTGTATTAATTCCTTACGTTTCTGGCACCAT
GGGACGGCCTGCACGGATGA

Product: TRAP dicarboxylate transporter subunit DctM

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MAITLFVSALLLMALGFPVAFALAMSAAIAVFVGGRYPQLIVFKEMFTGIDSFPLMAVPFFILAAEIMSGGALTVVLLRF
AAQFVGHLRGGLGHANILSLTLFSGISGSALADAAGPGSMMVKMMDKAGYSRAYAAALTASTAIVGPIIPPSIIMIIYAL
QDEQVSVGALFIAGFAPGILIAVAMAIVNWRVCVQRDYRSREPRPGGREMLANSIRAIPALMLVVLILVGIRFGIFTPTE
ASVVAVFYALVCGKWIYRTLEWKALPHIAARSALLTASVLLVVAASAAFAWVLTVEGVPQRLAETIVGWNLSPVTFLIAV
NILLLLFGIFMEPLPGVMILVPILAPISAALGIDPIHFAMVVIVNLTLGMITPPVGGLLFVTSVATKVPLAALTRELPPF
LVAHLIVLGLLTFVPAISTWLPHALGF

Sequences:

>Translated_427_residues
MAITLFVSALLLMALGFPVAFALAMSAAIAVFVGGRYPQLIVFKEMFTGIDSFPLMAVPFFILAAEIMSGGALTVVLLRF
AAQFVGHLRGGLGHANILSLTLFSGISGSALADAAGPGSMMVKMMDKAGYSRAYAAALTASTAIVGPIIPPSIIMIIYAL
QDEQVSVGALFIAGFAPGILIAVAMAIVNWRVCVQRDYRSREPRPGGREMLANSIRAIPALMLVVLILVGIRFGIFTPTE
ASVVAVFYALVCGKWIYRTLEWKALPHIAARSALLTASVLLVVAASAAFAWVLTVEGVPQRLAETIVGWNLSPVTFLIAV
NILLLLFGIFMEPLPGVMILVPILAPISAALGIDPIHFAMVVIVNLTLGMITPPVGGLLFVTSVATKVPLAALTRELPPF
LVAHLIVLGLLTFVPAISTWLPHALGF
>Mature_426_residues
AITLFVSALLLMALGFPVAFALAMSAAIAVFVGGRYPQLIVFKEMFTGIDSFPLMAVPFFILAAEIMSGGALTVVLLRFA
AQFVGHLRGGLGHANILSLTLFSGISGSALADAAGPGSMMVKMMDKAGYSRAYAAALTASTAIVGPIIPPSIIMIIYALQ
DEQVSVGALFIAGFAPGILIAVAMAIVNWRVCVQRDYRSREPRPGGREMLANSIRAIPALMLVVLILVGIRFGIFTPTEA
SVVAVFYALVCGKWIYRTLEWKALPHIAARSALLTASVLLVVAASAAFAWVLTVEGVPQRLAETIVGWNLSPVTFLIAVN
ILLLLFGIFMEPLPGVMILVPILAPISAALGIDPIHFAMVVIVNLTLGMITPPVGGLLFVTSVATKVPLAALTRELPPFL
VAHLIVLGLLTFVPAISTWLPHALGF

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=418, Percent_Identity=35.6459330143541, Blast_Score=203, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 45082; Mature: 44951

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITLFVSALLLMALGFPVAFALAMSAAIAVFVGGRYPQLIVFKEMFTGIDSFPLMAVPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHH
FILAAEIMSGGALTVVLLRFAAQFVGHLRGGLGHANILSLTLFSGISGSALADAAGPGSM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHCCCCCHHH
MVKMMDKAGYSRAYAAALTASTAIVGPIIPPSIIMIIYALQDEQVSVGALFIAGFAPGIL
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IAVAMAIVNWRVCVQRDYRSREPRPGGREMLANSIRAIPALMLVVLILVGIRFGIFTPTE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ASVVAVFYALVCGKWIYRTLEWKALPHIAARSALLTASVLLVVAASAAFAWVLTVEGVPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHH
RLAETIVGWNLSPVTFLIAVNILLLLFGIFMEPLPGVMILVPILAPISAALGIDPIHFAM
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
VVIVNLTLGMITPPVGGLLFVTSVATKVPLAALTRELPPFLVAHLIVLGLLTFVPAISTW
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LPHALGF
HHHHHCC
>Mature Secondary Structure 
AITLFVSALLLMALGFPVAFALAMSAAIAVFVGGRYPQLIVFKEMFTGIDSFPLMAVPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHH
FILAAEIMSGGALTVVLLRFAAQFVGHLRGGLGHANILSLTLFSGISGSALADAAGPGSM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHCCCCCHHH
MVKMMDKAGYSRAYAAALTASTAIVGPIIPPSIIMIIYALQDEQVSVGALFIAGFAPGIL
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IAVAMAIVNWRVCVQRDYRSREPRPGGREMLANSIRAIPALMLVVLILVGIRFGIFTPTE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ASVVAVFYALVCGKWIYRTLEWKALPHIAARSALLTASVLLVVAASAAFAWVLTVEGVPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHH
RLAETIVGWNLSPVTFLIAVNILLLLFGIFMEPLPGVMILVPILAPISAALGIDPIHFAM
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
VVIVNLTLGMITPPVGGLLFVTSVATKVPLAALTRELPPFLVAHLIVLGLLTFVPAISTW
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LPHALGF
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]