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The map label for this gene is tdcB [H]

Identifier: 120611875

GI number: 120611875

Start: 3548309

End: 3549283

Strand: Direct

Name: tdcB [H]

Synonym: Aave_3217

Alternate gene names: 120611875

Gene position: 3548309-3549283 (Clockwise)

Preceding gene: 120611874

Following gene: 120611876

Centisome position: 66.29

GC content: 72.62

Gene sequence:

>975_bases
ATGGAAACGCATTCCCCGGCCCCACCCACCTACGACGACGTGGCCGCCGCGGCCCGGCGCCTGGCGGGCATCGCCCACCG
CACGCCCGTGCTGCGCTCCAGCACCGCCGACGAGGCCCTGGGCGCCCAGCTCTTCTTCAAGTGCGAGAACCTCCAGCGCA
TGGGGGCCTTCAAGTTCCGGGGCGCCTACAACGCCCTCGTGCAGCTGGACGCCGCCCAGCGCGAGCGCGGCGTGCTGGCC
TTTTCCTCCGGCAACCATGCGCAGGCGATCGCGCTCTCGGCCCGCCTGCTCGACATGCCCGCGGTGATCGTCATGCCCGA
GGACGCGCCCGCCTCCAAGATGGCCGCCACGCGCGAATACGGCGCCCAGGTGGTCACCTACGACCGCTTCCGCGAAGACC
GCGAGGCCATCAGCCGGCGCCTGGCGGAGGAGCGCGGCATGGTGCTGGTGCCGCCCTTCGACCACCCCCACGTCATCGCC
GGCCAGGGCACGGCCGCGGTGGAGCTGCTGGAAGACGTGCCCGGGCTGGACTATCTCTTCGTCTGCCTGGGCGGCGGCGG
CCTGCTGTCGGGCTGCCTGCTCGCGGCCGAACAGCTGGCACCGGGCTGCAAGGTGGTCGGCGTGGAGCCGGAGGCCGGCA
ACGACGTGCAGCAATCGCTGCGTGCCGGACACATCGTGCGCATCGAGACGCCCCGCACCATCGCCGACGGCGCGCAGACC
CAGGCGCCCGGCGAGGTCACCTTCCCGATCATCCGGCGCCTGGTGCACGAGGTCGTCACCGTGGCCGACGCGCAGCTCGT
CCAGGCGCTCCGGTTCTTCGCCGAGCGCATGAAGATGGTCGTCGAGCCCACCGGGGCGCTCGCGCTGGCGGGCGCGCACC
ACGGCGGCATCGACCTGCGGGGCGCGCGCGTGGGCATCGTGGTCAGCGGCGGCAACGTCGATCTGCCGCGGTATGCGCGG
TTTCTGGCAGACTGA

Upstream 100 bases:

>100_bases
CCCCCGGCGGCCGGATCCGGCGGACGCAGAAAACGGCCTGGCCGGTCTATGATGCGGCAACCCTTTTCCGGACACCGCAC
ACGCTTCGCGAGGACGCTCC

Downstream 100 bases:

>100_bases
AGGGTTGTCTTCTTTTTCCCCTCCCTTTCCCACGCCCATGAGCACCCAGAACCCTTCCGGCAACGTCCACGTCATCACGC
ACCCGCTGGTGCAGCACAAG

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
METHSPAPPTYDDVAAAARRLAGIAHRTPVLRSSTADEALGAQLFFKCENLQRMGAFKFRGAYNALVQLDAAQRERGVLA
FSSGNHAQAIALSARLLDMPAVIVMPEDAPASKMAATREYGAQVVTYDRFREDREAISRRLAEERGMVLVPPFDHPHVIA
GQGTAAVELLEDVPGLDYLFVCLGGGGLLSGCLLAAEQLAPGCKVVGVEPEAGNDVQQSLRAGHIVRIETPRTIADGAQT
QAPGEVTFPIIRRLVHEVVTVADAQLVQALRFFAERMKMVVEPTGALALAGAHHGGIDLRGARVGIVVSGGNVDLPRYAR
FLAD

Sequences:

>Translated_324_residues
METHSPAPPTYDDVAAAARRLAGIAHRTPVLRSSTADEALGAQLFFKCENLQRMGAFKFRGAYNALVQLDAAQRERGVLA
FSSGNHAQAIALSARLLDMPAVIVMPEDAPASKMAATREYGAQVVTYDRFREDREAISRRLAEERGMVLVPPFDHPHVIA
GQGTAAVELLEDVPGLDYLFVCLGGGGLLSGCLLAAEQLAPGCKVVGVEPEAGNDVQQSLRAGHIVRIETPRTIADGAQT
QAPGEVTFPIIRRLVHEVVTVADAQLVQALRFFAERMKMVVEPTGALALAGAHHGGIDLRGARVGIVVSGGNVDLPRYAR
FLAD
>Mature_324_residues
METHSPAPPTYDDVAAAARRLAGIAHRTPVLRSSTADEALGAQLFFKCENLQRMGAFKFRGAYNALVQLDAAQRERGVLA
FSSGNHAQAIALSARLLDMPAVIVMPEDAPASKMAATREYGAQVVTYDRFREDREAISRRLAEERGMVLVPPFDHPHVIA
GQGTAAVELLEDVPGLDYLFVCLGGGGLLSGCLLAAEQLAPGCKVVGVEPEAGNDVQQSLRAGHIVRIETPRTIADGAQT
QAPGEVTFPIIRRLVHEVVTVADAQLVQALRFFAERMKMVVEPTGALALAGAHHGGIDLRGARVGIVVSGGNVDLPRYAR
FLAD

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=41.2140575079872, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI19923959, Length=298, Percent_Identity=28.1879194630872, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI295821202, Length=200, Percent_Identity=29, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI295821200, Length=200, Percent_Identity=29, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4557415, Length=200, Percent_Identity=29, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=38.4858044164038, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1790207, Length=296, Percent_Identity=36.4864864864865, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17508781, Length=310, Percent_Identity=35.1612903225806, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71991565, Length=319, Percent_Identity=31.6614420062696, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=320, Percent_Identity=31.875, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322631, Length=315, Percent_Identity=61.5873015873016, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320930, Length=310, Percent_Identity=36.4516129032258, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319788, Length=298, Percent_Identity=26.510067114094, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=34.1692789968652, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24645328, Length=219, Percent_Identity=32.4200913242009, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34559; Mature: 34559

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METHSPAPPTYDDVAAAARRLAGIAHRTPVLRSSTADEALGAQLFFKCENLQRMGAFKFR
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GAYNALVQLDAAQRERGVLAFSSGNHAQAIALSARLLDMPAVIVMPEDAPASKMAATREY
CHHHHHEEECHHHHHCCEEEECCCCCCCCEEHHHHHHCCCEEEEECCCCCHHHHHHHHHH
GAQVVTYDRFREDREAISRRLAEERGMVLVPPFDHPHVIAGQGTAAVELLEDVPGLDYLF
CCEEEEHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCHHHHHHHHHCCCCCEEE
VCLGGGGLLSGCLLAAEQLAPGCKVVGVEPEAGNDVQQSLRAGHIVRIETPRTIADGAQT
EEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHCCCCC
QAPGEVTFPIIRRLVHEVVTVADAQLVQALRFFAERMKMVVEPTGALALAGAHHGGIDLR
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEC
GARVGIVVSGGNVDLPRYARFLAD
CCEEEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
METHSPAPPTYDDVAAAARRLAGIAHRTPVLRSSTADEALGAQLFFKCENLQRMGAFKFR
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GAYNALVQLDAAQRERGVLAFSSGNHAQAIALSARLLDMPAVIVMPEDAPASKMAATREY
CHHHHHEEECHHHHHCCEEEECCCCCCCCEEHHHHHHCCCEEEEECCCCCHHHHHHHHHH
GAQVVTYDRFREDREAISRRLAEERGMVLVPPFDHPHVIAGQGTAAVELLEDVPGLDYLF
CCEEEEHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCHHHHHHHHHCCCCCEEE
VCLGGGGLLSGCLLAAEQLAPGCKVVGVEPEAGNDVQQSLRAGHIVRIETPRTIADGAQT
EEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHCCCCC
QAPGEVTFPIIRRLVHEVVTVADAQLVQALRFFAERMKMVVEPTGALALAGAHHGGIDLR
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEC
GARVGIVVSGGNVDLPRYARFLAD
CCEEEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]