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The map label for this gene is crt [H]

Identifier: 120611874

GI number: 120611874

Start: 3547344

End: 3548195

Strand: Direct

Name: crt [H]

Synonym: Aave_3216

Alternate gene names: 120611874

Gene position: 3547344-3548195 (Clockwise)

Preceding gene: 120611873

Following gene: 120611875

Centisome position: 66.27

GC content: 70.77

Gene sequence:

>852_bases
ATGACCGACACCGCCGCCCTCACCTGCTTCCGCCTGACCGTCACGGACCACGTCGCGCACCTGGTGCTCGACCGCCCGGA
CGCGCTCAACACCATGCACCCCACCTTCTGGCGCGAGCTGGACACGGCGCTCGCGCGGATCCACCGCTCGGGCGATGCGC
GGGCGCTGGTCATCAGCAGCACCGGCAGGCACTTCTCGGCCGGCATGTCGCTGGACACCTTCGGCGGCGCCGTCGCCATG
GACGACCAGAGCCCGGAAGGCCGCGCCGCGATCTTCGACCTGCTGACCGACATGCAGGCCACCTTCACCCGCATCGAATC
GCTGCGCATCCCGGTCATCGCCGCGATCCACGGCGGCTGCATCGGCGGCGCGGTGGACATGGTGACGGCCGCCTGCATCC
GCTACGCCACCGAGGACGCCTTCTTCTGCATCCAGGAGATCAACATCGGCATGGTGGCCGACGTGGGCACGCTGCAGCGC
CTGCCCAAGCTGATCCCGCTGGGCATCGTCAAGGAACTGGCCTACACCGGCCGCCGCCTGCCCGCCGCCCGCGCCCTGGC
CTGCGGGCTGGTCAACGAAGTGTTCGCCACGCAGGAGGCCATGCTGGAAGCAGCCCTGGCCTGCGCGCGCGAGATCGCCG
CCAAGCCGCCGGTGGCCATCTGGGGCACCAAGCAGGCCGTGCATTACGCACGCGACCACTCCGTGGACGACAGCCTGCGC
CAGATGGGCTGGCTGCAGGGCACGGTGTGGAGCAACCGCCACGTGGGCGAGGCCGTGGGCGCGATGCGCGAGCGGCGCGC
GGGCGACTTCCCTGATCTGGCGCCAGTGCAGCGCTTCAGCGAACTGGGCTGA

Upstream 100 bases:

>100_bases
GACCGTGCTGACCGTGCTGGCCGGCGCCCGGCGCACCCCGCGCGGCCGCCGTCGCGCAGGTGACGGCCGGCCGCGCCGCA
TCCCGCCTAGAGTGCGCCGC

Downstream 100 bases:

>100_bases
CCCGGCAGGAGGGCCCCCGGCGGCCGGATCCGGCGGACGCAGAAAACGGCCTGGCCGGTCTATGATGCGGCAACCCTTTT
CCGGACACCGCACACGCTTC

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTDTAALTCFRLTVTDHVAHLVLDRPDALNTMHPTFWRELDTALARIHRSGDARALVISSTGRHFSAGMSLDTFGGAVAM
DDQSPEGRAAIFDLLTDMQATFTRIESLRIPVIAAIHGGCIGGAVDMVTAACIRYATEDAFFCIQEINIGMVADVGTLQR
LPKLIPLGIVKELAYTGRRLPAARALACGLVNEVFATQEAMLEAALACAREIAAKPPVAIWGTKQAVHYARDHSVDDSLR
QMGWLQGTVWSNRHVGEAVGAMRERRAGDFPDLAPVQRFSELG

Sequences:

>Translated_283_residues
MTDTAALTCFRLTVTDHVAHLVLDRPDALNTMHPTFWRELDTALARIHRSGDARALVISSTGRHFSAGMSLDTFGGAVAM
DDQSPEGRAAIFDLLTDMQATFTRIESLRIPVIAAIHGGCIGGAVDMVTAACIRYATEDAFFCIQEINIGMVADVGTLQR
LPKLIPLGIVKELAYTGRRLPAARALACGLVNEVFATQEAMLEAALACAREIAAKPPVAIWGTKQAVHYARDHSVDDSLR
QMGWLQGTVWSNRHVGEAVGAMRERRAGDFPDLAPVQRFSELG
>Mature_282_residues
TDTAALTCFRLTVTDHVAHLVLDRPDALNTMHPTFWRELDTALARIHRSGDARALVISSTGRHFSAGMSLDTFGGAVAMD
DQSPEGRAAIFDLLTDMQATFTRIESLRIPVIAAIHGGCIGGAVDMVTAACIRYATEDAFFCIQEINIGMVADVGTLQRL
PKLIPLGIVKELAYTGRRLPAARALACGLVNEVFATQEAMLEAALACAREIAAKPPVAIWGTKQAVHYARDHSVDDSLRQ
MGWLQGTVWSNRHVGEAVGAMRERRAGDFPDLAPVQRFSELG

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=253, Percent_Identity=44.2687747035573, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI194097323, Length=258, Percent_Identity=25.5813953488372, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI20127408, Length=218, Percent_Identity=25.6880733944954, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI221142681, Length=235, Percent_Identity=29.7872340425532, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788682, Length=209, Percent_Identity=29.1866028708134, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787659, Length=258, Percent_Identity=24.8062015503876, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790281, Length=204, Percent_Identity=25.9803921568627, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87082183, Length=266, Percent_Identity=24.0601503759398, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=25.6704980842912, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17534483, Length=265, Percent_Identity=34.7169811320755, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17536985, Length=279, Percent_Identity=31.5412186379928, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25145438, Length=261, Percent_Identity=27.2030651340996, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17558304, Length=225, Percent_Identity=27.1111111111111, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=26.6932270916335, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540714, Length=230, Percent_Identity=25.2173913043478, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144276, Length=228, Percent_Identity=27.6315789473684, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=228, Percent_Identity=27.6315789473684, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=228, Percent_Identity=27.6315789473684, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=219, Percent_Identity=24.2009132420091, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920382, Length=248, Percent_Identity=37.5, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24653139, Length=250, Percent_Identity=28.8, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI20129971, Length=257, Percent_Identity=24.9027237354086, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24653477, Length=257, Percent_Identity=24.9027237354086, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 30641; Mature: 30509

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTAALTCFRLTVTDHVAHLVLDRPDALNTMHPTFWRELDTALARIHRSGDARALVISS
CCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEC
TGRHFSAGMSLDTFGGAVAMDDQSPEGRAAIFDLLTDMQATFTRIESLRIPVIAAIHGGC
CCCEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCH
IGGAVDMVTAACIRYATEDAFFCIQEINIGMVADVGTLQRLPKLIPLGIVKELAYTGRRL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCC
PAARALACGLVNEVFATQEAMLEAALACAREIAAKPPVAIWGTKQAVHYARDHSVDDSLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCHHHHHH
QMGWLQGTVWSNRHVGEAVGAMRERRAGDFPDLAPVQRFSELG
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TDTAALTCFRLTVTDHVAHLVLDRPDALNTMHPTFWRELDTALARIHRSGDARALVISS
CCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEC
TGRHFSAGMSLDTFGGAVAMDDQSPEGRAAIFDLLTDMQATFTRIESLRIPVIAAIHGGC
CCCEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCH
IGGAVDMVTAACIRYATEDAFFCIQEINIGMVADVGTLQRLPKLIPLGIVKELAYTGRRL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCC
PAARALACGLVNEVFATQEAMLEAALACAREIAAKPPVAIWGTKQAVHYARDHSVDDSLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCHHHHHH
QMGWLQGTVWSNRHVGEAVGAMRERRAGDFPDLAPVQRFSELG
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]