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The map label for this gene is upp [H]

Identifier: 120611876

GI number: 120611876

Start: 3549321

End: 3549968

Strand: Direct

Name: upp [H]

Synonym: Aave_3218

Alternate gene names: 120611876

Gene position: 3549321-3549968 (Clockwise)

Preceding gene: 120611875

Following gene: 120611877

Centisome position: 66.31

GC content: 66.51

Gene sequence:

>648_bases
ATGAGCACCCAGAACCCTTCCGGCAACGTCCACGTCATCACGCACCCGCTGGTGCAGCACAAGCTGACCCTCATGCGCCG
CAAGGACGCCAGCACCAACAGCTTCCGCCGCCTGCTGGGCGAGCTGAGCACCCTGATGGCCTACGAGATCACGCGCGACA
TGCCGCTGTCGGACATCGAGGTCGAGACGCCGCTGGAGACCATGACCGGCAAGGTCATCGACGGCAAGAAGCTGGTGCTC
GTCTCCATCCTGCGCGCGGGCAACGGCTTCCTGGACGGCATGCTGACCGTGGTGCCGGGCGCCCGCGTCGGCCACATCGG
CCTCTACCGCGACCCGCAGACGCTGCAGCCGGTGGAGTACTACTTCAAGATGCCCTCCGAGATGGAAGAGCGCGACATCA
TCGTGGTGGACCCGATGCTGGCCACCGGCAACTCCGCCGCGGCCGCCGTCGCCAAGCTCAAGGAACTCAAGCCGCGTTCG
GTGAAGTTCATGTGCCTGCTGGCCGCGCCCGAAGGCGTCGCCACGCTGCAGAAGGCGCACCCGGACGTGCCCATCTTCAC
CGCCGCGATCGACCGCGAACTCAACGACCACGGCTACATCCTGCCGGGGCTGGGGGATGCGGGGGACCGGATTTTCGGCA
CCAAATGA

Upstream 100 bases:

>100_bases
GGCATCGTGGTCAGCGGCGGCAACGTCGATCTGCCGCGGTATGCGCGGTTTCTGGCAGACTGAAGGGTTGTCTTCTTTTT
CCCCTCCCTTTCCCACGCCC

Downstream 100 bases:

>100_bases
TGAAGATGGCCTGAGCCGCCCGCGATAGGCCAGCGCGCACGGGCATGCCGGCGCGCTGCAGTGCGCGGACCGATCCTCTC
GCGCCCGCCGGGGCGGGTCG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSTQNPSGNVHVITHPLVQHKLTLMRRKDASTNSFRRLLGELSTLMAYEITRDMPLSDIEVETPLETMTGKVIDGKKLVL
VSILRAGNGFLDGMLTVVPGARVGHIGLYRDPQTLQPVEYYFKMPSEMEERDIIVVDPMLATGNSAAAAVAKLKELKPRS
VKFMCLLAAPEGVATLQKAHPDVPIFTAAIDRELNDHGYILPGLGDAGDRIFGTK

Sequences:

>Translated_215_residues
MSTQNPSGNVHVITHPLVQHKLTLMRRKDASTNSFRRLLGELSTLMAYEITRDMPLSDIEVETPLETMTGKVIDGKKLVL
VSILRAGNGFLDGMLTVVPGARVGHIGLYRDPQTLQPVEYYFKMPSEMEERDIIVVDPMLATGNSAAAAVAKLKELKPRS
VKFMCLLAAPEGVATLQKAHPDVPIFTAAIDRELNDHGYILPGLGDAGDRIFGTK
>Mature_214_residues
STQNPSGNVHVITHPLVQHKLTLMRRKDASTNSFRRLLGELSTLMAYEITRDMPLSDIEVETPLETMTGKVIDGKKLVLV
SILRAGNGFLDGMLTVVPGARVGHIGLYRDPQTLQPVEYYFKMPSEMEERDIIVVDPMLATGNSAAAAVAKLKELKPRSV
KFMCLLAAPEGVATLQKAHPDVPIFTAAIDRELNDHGYILPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=32.1782178217822, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=32.1782178217822, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI21450816, Length=174, Percent_Identity=28.1609195402299, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=51.2315270935961, Blast_Score=216, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17539894, Length=202, Percent_Identity=26.7326732673267, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17539892, Length=202, Percent_Identity=26.7326732673267, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321920, Length=218, Percent_Identity=34.4036697247706, Blast_Score=112, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=32.0388349514563, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=32.0388349514563, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=32.0388349514563, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=32.0388349514563, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21358379, Length=199, Percent_Identity=26.6331658291457, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23536; Mature: 23405

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQNPSGNVHVITHPLVQHKLTLMRRKDASTNSFRRLLGELSTLMAYEITRDMPLSDIE
CCCCCCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
VETPLETMTGKVIDGKKLVLVSILRAGNGFLDGMLTVVPGARVGHIGLYRDPQTLQPVEY
ECCCHHHHCCCEECCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHH
YFKMPSEMEERDIIVVDPMLATGNSAAAAVAKLKELKPRSVKFMCLLAAPEGVATLQKAH
HHCCCCCCCCCCEEEECCCEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCC
PDVPIFTAAIDRELNDHGYILPGLGDAGDRIFGTK
CCCCEEEHHHHCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
STQNPSGNVHVITHPLVQHKLTLMRRKDASTNSFRRLLGELSTLMAYEITRDMPLSDIE
CCCCCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
VETPLETMTGKVIDGKKLVLVSILRAGNGFLDGMLTVVPGARVGHIGLYRDPQTLQPVEY
ECCCHHHHCCCEECCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHH
YFKMPSEMEERDIIVVDPMLATGNSAAAAVAKLKELKPRSVKFMCLLAAPEGVATLQKAH
HHCCCCCCCCCCEEEECCCEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCC
PDVPIFTAAIDRELNDHGYILPGLGDAGDRIFGTK
CCCCEEEHHHHCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA