Click here to switch to the map view.

The map label for this gene is lpxK [H]

Identifier: 120611233

GI number: 120611233

Start: 2815448

End: 2816491

Strand: Reverse

Name: lpxK [H]

Synonym: Aave_2564

Alternate gene names: 120611233

Gene position: 2816491-2815448 (Counterclockwise)

Preceding gene: 120611234

Following gene: 120611232

Centisome position: 52.62

GC content: 73.75

Gene sequence:

>1044_bases
ATGGCGCAGCCACGCCGCCGCGGACGATCCGCGCCGGACGCGACGCCGGGGATCCAGCGGGTGTGGCGCCACCGCGGCGC
GATGGCCTGGCTGCTGTCGCCCATCTCCCTCCTCTACGGCGCCCTGGCCGGTTTGCGGCGGCTGCTCTATGTCCGGGGAG
TATTGCGGGTGGAGCGCCTGCCCGTTCCCGTGGTCGTCGTGGGCAACGTAGTGGCCGGCGGCGCCGGCAAGACCCCCGTG
ACCCTGGCCGTCGTGCAGGCGCTGCGGCGGCATGGATGGCACCCGGGCGTGGTGTCCCGCGGGTACGGGCGCGGCACCTC
CGACTGCCGCGAGGTGCTGGCGGGCAGCAGCGCCGCCGAGTCCGGAGACGAGCCCCTGCTGATCGCGCGGTCCACCGGCG
TGCCGGTGTTCGTCGCGCCACGGCGCGCGCAGGCGGCCCGCGCCCTGCTGGAGCGGCATCCGCGGACCGACGTGGTCGTC
TGCGACGACGGTCTGCAGCACTGGGCGCTGGCCCGGGATGTGGAGCTGTGCGTATTCAGCGAGGAAGGCATCGGCAACGG
ATGGCTGCTGCCGGCCGGCCCGCTGCGCGAGCGCTGGCCGCGGCACGTGGATGCCGTGCTGCACGCCGGAGCCGCCCCTG
AAGGCGCGGACCGCGCCCCCATGGGGGCGTTCGCCCTGCGGAGGTCGCTCGCGTCCCATGCGGTGGATGCCACCGGAAGC
ACCACGGCACTTTCGTGCCTGCGCGGTCGGCCCGTGCATGCCGTGGCCGCGATTGCCCGGCCCGCCGCCTTTTTCGCCAT
GCTGCGTGCCGAAGGGCTCACGCTGGCGAAGGAAACCGCCCTGCCCGACCATGCGGACTTCTCGGACTGGGCCCCCGTCA
CGGATCCGGGCATGCCGCTGGTATGCACCGAAAAGGATGCCGCCAAACTCTGGCGGACCCATCCCCAGGCGCTGGCGGTG
CCGCTCGTGGTGGACATCCCTGCCGCTTTCTTCGACCGGCTGCACGCGCGACTGCAGGCGCTGCCGCGCCGGCGCTCGCT
ATGA

Upstream 100 bases:

>100_bases
ACCAGGCCGTGATTTCCGTGATGGAAGCCGCGCGCCGCGCGGGCCTGTCGCAGATCACCTTCGCCACGCAATCGTCCGCC
AGCGCGGGCCGCTGATCCGC

Downstream 100 bases:

>100_bases
TCGGTTTCCCTTTTTTCTGAACACGCTTGTCACGCCATGGATCCCAAACTGCTCGAACTGCTGGTCTGCCCGGTCACCAA
GGGTCCGCTGACCTACGACC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MAQPRRRGRSAPDATPGIQRVWRHRGAMAWLLSPISLLYGALAGLRRLLYVRGVLRVERLPVPVVVVGNVVAGGAGKTPV
TLAVVQALRRHGWHPGVVSRGYGRGTSDCREVLAGSSAAESGDEPLLIARSTGVPVFVAPRRAQAARALLERHPRTDVVV
CDDGLQHWALARDVELCVFSEEGIGNGWLLPAGPLRERWPRHVDAVLHAGAAPEGADRAPMGAFALRRSLASHAVDATGS
TTALSCLRGRPVHAVAAIARPAAFFAMLRAEGLTLAKETALPDHADFSDWAPVTDPGMPLVCTEKDAAKLWRTHPQALAV
PLVVDIPAAFFDRLHARLQALPRRRSL

Sequences:

>Translated_347_residues
MAQPRRRGRSAPDATPGIQRVWRHRGAMAWLLSPISLLYGALAGLRRLLYVRGVLRVERLPVPVVVVGNVVAGGAGKTPV
TLAVVQALRRHGWHPGVVSRGYGRGTSDCREVLAGSSAAESGDEPLLIARSTGVPVFVAPRRAQAARALLERHPRTDVVV
CDDGLQHWALARDVELCVFSEEGIGNGWLLPAGPLRERWPRHVDAVLHAGAAPEGADRAPMGAFALRRSLASHAVDATGS
TTALSCLRGRPVHAVAAIARPAAFFAMLRAEGLTLAKETALPDHADFSDWAPVTDPGMPLVCTEKDAAKLWRTHPQALAV
PLVVDIPAAFFDRLHARLQALPRRRSL
>Mature_346_residues
AQPRRRGRSAPDATPGIQRVWRHRGAMAWLLSPISLLYGALAGLRRLLYVRGVLRVERLPVPVVVVGNVVAGGAGKTPVT
LAVVQALRRHGWHPGVVSRGYGRGTSDCREVLAGSSAAESGDEPLLIARSTGVPVFVAPRRAQAARALLERHPRTDVVVC
DDGLQHWALARDVELCVFSEEGIGNGWLLPAGPLRERWPRHVDAVLHAGAAPEGADRAPMGAFALRRSLASHAVDATGST
TALSCLRGRPVHAVAAIARPAAFFAMLRAEGLTLAKETALPDHADFSDWAPVTDPGMPLVCTEKDAAKLWRTHPQALAVP
LVVDIPAAFFDRLHARLQALPRRRSL

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=302, Percent_Identity=43.046357615894, Blast_Score=193, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 37239; Mature: 37108

Theoretical pI: Translated: 11.27; Mature: 11.27

Prosite motif: PS01159 WW_DOMAIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPRRRGRSAPDATPGIQRVWRHRGAMAWLLSPISLLYGALAGLRRLLYVRGVLRVERL
CCCCHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVPVVVVGNVVAGGAGKTPVTLAVVQALRRHGWHPGVVSRGYGRGTSDCREVLAGSSAAE
CCCEEEECCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
SGDEPLLIARSTGVPVFVAPRRAQAARALLERHPRTDVVVCDDGLQHWALARDVELCVFS
CCCCCEEEEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCEEEEEE
EEGIGNGWLLPAGPLRERWPRHVDAVLHAGAAPEGADRAPMGAFALRRSLASHAVDATGS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
TTALSCLRGRPVHAVAAIARPAAFFAMLRAEGLTLAKETALPDHADFSDWAPVTDPGMPL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCEE
VCTEKDAAKLWRTHPQALAVPLVVDIPAAFFDRLHARLQALPRRRSL
EECCHHHHHHHHCCHHHHEEHHHHHCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQPRRRGRSAPDATPGIQRVWRHRGAMAWLLSPISLLYGALAGLRRLLYVRGVLRVERL
CCCHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVPVVVVGNVVAGGAGKTPVTLAVVQALRRHGWHPGVVSRGYGRGTSDCREVLAGSSAAE
CCCEEEECCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
SGDEPLLIARSTGVPVFVAPRRAQAARALLERHPRTDVVVCDDGLQHWALARDVELCVFS
CCCCCEEEEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCEEEEEE
EEGIGNGWLLPAGPLRERWPRHVDAVLHAGAAPEGADRAPMGAFALRRSLASHAVDATGS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
TTALSCLRGRPVHAVAAIARPAAFFAMLRAEGLTLAKETALPDHADFSDWAPVTDPGMPL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCEE
VCTEKDAAKLWRTHPQALAVPLVVDIPAAFFDRLHARLQALPRRRSL
EECCHHHHHHHHCCHHHHEEHHHHHCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA