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The map label for this gene is pccB [H]

Identifier: 120611182

GI number: 120611182

Start: 2753143

End: 2754675

Strand: Direct

Name: pccB [H]

Synonym: Aave_2513

Alternate gene names: 120611182

Gene position: 2753143-2754675 (Clockwise)

Preceding gene: 120611181

Following gene: 120611183

Centisome position: 51.43

GC content: 65.36

Gene sequence:

>1533_bases
ATGCAAGACATCCTGGAACAGCTGGAGAAAAAGCGCGAGCAGGCCCGCCAGGGCGGCGGCGCGAAGCGCATCGAGGCGCA
GCACAGGAAGGGCAAGCTCACCGCGCGCGAACGCATCGAACTGCTGCTGGACGACGGCACCTTCGAGGAGTGGGACATGT
TCGTCGAGCACCGCTGCACCGACTTCGGCATGCAGGACCAGAAGATCCCCGGCGACGGCGTGGTGACGGGCTACGGCATG
ATCAACGGCCGGCTGGTCTTCGTCTTCAGCCAGGACTTCACCGTGTTCGGCGGCGCGCTGTCGGAGGCGCACGCAGAGAA
GATCTGCAAGATCATGGACCAGGCCATGAAGGTCGGCGCCCCGGTGATCGGCCTGAACGATTCGGGCGGTGCGCGCATCC
AGGAAGGCGTAGCCTCCCTGGGCGGCTATGCGGACGTGTTCCAGAAGAACGTGATGGCCTCGGGCGTGATCCCGCAGATC
AGCATGGTGATGGGGCCCTGCGCGGGCGGCGCCGTCTATTCGCCCGCCATGACGGACTTCATCTTCATGGTGAAGGATTC
GAGCTACATGTTCGTCACCGGGCCCGAGGTGGTCAAGACCGTGACGCATGAAGAGGTCACGGCGGAGGAACTGGGGGGCG
CCGTCACCCACACCACGCGCAGCGGCGTGGCCGACATGGCCTTCGAGAACGACGTGGAGGCGCTCATGATGCTGCGGCGC
CTGTACAACTACCTGCCGCTCAACAACCGCGAGAAACCCCCGGTGCGCAGGAGCACCGATCCGGCGGACCGCAAGGACCT
GAGCCTGGACACCCTGGTGCCCGAGAACCCCAACAAGCCCTACGACATGAAGGAGCTGATCGCCAAGACGGTGGACGACG
GCGACTTCTTCGAGTTGCAGCCCGACTACGCGCGCAACATCGTCGTGGGCTTCGGCCGCATGGACGGGCAGGTGGTGGGC
ATCGTGGCGAACCAGCCGCTGGTGCTGGCGGGCTGCCTGGACATCAAGTCCAGCATCAAGGCCGCGCGCTTCGTGCGCTT
CTGCGATGCCTTCAACATCCCCATCGTGACCTACGTGGACGTGCCCGGCTTCATGCCCGGCACCAGCCAGGAATACGGCG
GCATCATCAAGCACGGCGCCAAGCTGCTGTACGCGTATGCCGAGGCCACCGTGCCCAAGATCACCGTGATCACGCGCAAG
GCCTACGGCGGCGCCTACGACGTGATGGCCTCCAAGCACCTGCGCGGCGACGTGAACCTGGCCTGGCCCAACGCGGAGAT
CGCGGTGATGGGCGCCAAGGGCGCCGTGGAGATCATCTTCCGCGAGGACAAGAACGACCCCGCCAAGCTGGCCGCGCGCG
AGGCCGAGTACAAGGCCCGCTTCGCCAACCCCTTCGTGGCCGGCAGCCGGGGCTTCATCGACGACGTGATCCTGCCGCAC
GAGACGCGAAAGCGCATCTGCCGCAGCCTGGTCATGCTGCAGAACAAGAAGATCGAGAACCCGTGGCGCAAGCACGGCAA
CATTCCATTGTGA

Upstream 100 bases:

>100_bases
GCAGGCGGGCGGCTTCGCGCCCCCCTGACCGGCCCGCGCGGGCCGCGGGCGCCACACGGACATTCGCACAGACAATTCAC
GGATCGTTGGAAGGAAGACC

Downstream 100 bases:

>100_bases
GCCGCCGCACCGCGAAGCCCTGCACGGCCGCTCGGACGAACCTCCCGGGAGCACGATGAAAACCGTCTGGATCATCGATG
GCGCCTACCTCTTCAACTAC

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MQDILEQLEKKREQARQGGGAKRIEAQHRKGKLTARERIELLLDDGTFEEWDMFVEHRCTDFGMQDQKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKIMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQKNVMASGVIPQI
SMVMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAVTHTTRSGVADMAFENDVEALMMLRR
LYNYLPLNNREKPPVRRSTDPADRKDLSLDTLVPENPNKPYDMKELIAKTVDDGDFFELQPDYARNIVVGFGRMDGQVVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPIVTYVDVPGFMPGTSQEYGGIIKHGAKLLYAYAEATVPKITVITRK
AYGGAYDVMASKHLRGDVNLAWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGSRGFIDDVILPH
ETRKRICRSLVMLQNKKIENPWRKHGNIPL

Sequences:

>Translated_510_residues
MQDILEQLEKKREQARQGGGAKRIEAQHRKGKLTARERIELLLDDGTFEEWDMFVEHRCTDFGMQDQKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKIMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQKNVMASGVIPQI
SMVMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAVTHTTRSGVADMAFENDVEALMMLRR
LYNYLPLNNREKPPVRRSTDPADRKDLSLDTLVPENPNKPYDMKELIAKTVDDGDFFELQPDYARNIVVGFGRMDGQVVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPIVTYVDVPGFMPGTSQEYGGIIKHGAKLLYAYAEATVPKITVITRK
AYGGAYDVMASKHLRGDVNLAWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGSRGFIDDVILPH
ETRKRICRSLVMLQNKKIENPWRKHGNIPL
>Mature_510_residues
MQDILEQLEKKREQARQGGGAKRIEAQHRKGKLTARERIELLLDDGTFEEWDMFVEHRCTDFGMQDQKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKIMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQKNVMASGVIPQI
SMVMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAVTHTTRSGVADMAFENDVEALMMLRR
LYNYLPLNNREKPPVRRSTDPADRKDLSLDTLVPENPNKPYDMKELIAKTVDDGDFFELQPDYARNIVVGFGRMDGQVVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPIVTYVDVPGFMPGTSQEYGGIIKHGAKLLYAYAEATVPKITVITRK
AYGGAYDVMASKHLRGDVNLAWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGSRGFIDDVILPH
ETRKRICRSLVMLQNKKIENPWRKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=69.6252465483235, Blast_Score=743, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=66.9829222011385, Blast_Score=731, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=523, Percent_Identity=33.8432122370937, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI38679971, Length=389, Percent_Identity=23.1362467866324, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI38679974, Length=389, Percent_Identity=23.1362467866324, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI38679960, Length=389, Percent_Identity=23.1362467866324, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI38679977, Length=389, Percent_Identity=23.1362467866324, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI38679967, Length=389, Percent_Identity=23.1362467866324, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI134142062, Length=401, Percent_Identity=21.9451371571072, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1788655, Length=188, Percent_Identity=26.5957446808511, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=69.0335305719921, Blast_Score=756, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=69.0335305719921, Blast_Score=754, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=504, Percent_Identity=34.3253968253968, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24586065, Length=530, Percent_Identity=33.7735849056604, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56212; Mature: 56212

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDILEQLEKKREQARQGGGAKRIEAQHRKGKLTARERIELLLDDGTFEEWDMFVEHRCT
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHHHH
DFGMQDQKIPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSEAHAEKICKIMDQAMKVGA
CCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYADVFQKNVMASGVIPQISMVMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAVTHTTRSGVADMAFENDVEALMMLRR
EEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCHHHHHHHHH
LYNYLPLNNREKPPVRRSTDPADRKDLSLDTLVPENPNKPYDMKELIAKTVDDGDFFELQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PDYARNIVVGFGRMDGQVVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPIVTYVD
CHHHCEEEEEECCCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTSQEYGGIIKHGAKLLYAYAEATVPKITVITRKAYGGAYDVMASKHLRGDVNL
CCCCCCCCCHHHCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEE
AWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGSRGFIDDVILPH
ECCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCC
ETRKRICRSLVMLQNKKIENPWRKHGNIPL
HHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MQDILEQLEKKREQARQGGGAKRIEAQHRKGKLTARERIELLLDDGTFEEWDMFVEHRCT
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHHHH
DFGMQDQKIPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSEAHAEKICKIMDQAMKVGA
CCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYADVFQKNVMASGVIPQISMVMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAVTHTTRSGVADMAFENDVEALMMLRR
EEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCHHHHHHHHH
LYNYLPLNNREKPPVRRSTDPADRKDLSLDTLVPENPNKPYDMKELIAKTVDDGDFFELQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PDYARNIVVGFGRMDGQVVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPIVTYVD
CHHHCEEEEEECCCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTSQEYGGIIKHGAKLLYAYAEATVPKITVITRKAYGGAYDVMASKHLRGDVNL
CCCCCCCCCHHHCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEE
AWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGSRGFIDDVILPH
ECCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCC
ETRKRICRSLVMLQNKKIENPWRKHGNIPL
HHHHHHHHHHHHHHCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]