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The map label for this gene is aphA [H]

Identifier: 120611121

GI number: 120611121

Start: 2674045

End: 2675115

Strand: Direct

Name: aphA [H]

Synonym: Aave_2450

Alternate gene names: 120611121

Gene position: 2674045-2675115 (Clockwise)

Preceding gene: 120611120

Following gene: 120611122

Centisome position: 49.96

GC content: 69.19

Gene sequence:

>1071_bases
GTGATCATCTACCACAACCCCTCGCACCGTCTCCACGCGCCGGTCCACGAGTTCTTCCGGGGCGAGCGTGTTCCCTGCTT
CGAGAAGCCCGACCGCGCCGATTACGTGGAGGCCCGGCTGCGCCGGCAGGGTTACGCGCTGCGTGCTCCGGACACGGACA
GCCAGGCCGTCCTGGCACGTGTGCACGCGCCGCGGTACCTGCGCTTCCTGCAGGACGCATGGCCGCAATGGCTGTCGCTG
GATGAGCGCAATGCCGGCGTGCAGCCGTTTCCTTCGGTCTGGCCGGTGCGTACGCTGCGTGACGATGTCGAACCCGAGAA
CTTCGTCGCGCGGCTGGGCCTGTATTCCATGGACAACGGCTCACCCCTGTCCGAAGGCACCTGGGCGGCAGCCAAGGCGG
GTGCCGATGCGGCCGCGAGCGCGGCGGCCGCGGTGGCGGCGGGAGCGCGTGCCGCGTTCTGCTGCACCCGTCCTCCGGGC
CACCACGCCGGGCCCGACTTCATGGGCGGCTACTGCTTTCTCAACAATGCGGCCGTGGCGGCCCAGTGGCTGCTCGATGC
CGGCACCGCCCGCCGCGTGGCCGTGCTGGATGTGGACTACCACCATGGCAACGGCACGCAAAGCATCTTTTACGATCGCT
CCGACGTGATGTGCATCAGCATCCATGGCGACCCGCGGACCGAGTATCCGTTCTATCTGGGGCATGCCGACGAAACCGGC
GCGGGCCCCGGCGCAGGCTTCAATTTCAATATCCCGCTGCCGGCCGGAACCGCCTTTCCCGACTGGCTCGGCGCGCTCGA
CCGGGCCTGCGCGCGTGTCGAGGAATGCGGCGCGCAGGCGCTGGTCGTGCCGCTGGGCCTCGACACGTTCGAGGGCGACC
CCATCTCGCGGTTCACGCTGTCGTCGCCGGACTTCATCGAAGTGGGCGCCAGACTCGCAGGCCTCGGGCTGCCGACGGTC
TTCGTGCTCGAAGGCGGATACGCGGCTGCCGAACTGGGGGTGAACGCAGTCAACGTGCTCGAGGGCTTCGAGCGCGTGGC
GGGCGGTGCCGGACCGAAAGGGCGGCCATGA

Upstream 100 bases:

>100_bases
TTGCTTTGCGCGCGCTGGCGGCCAGGCGCTGCTCCCGGCGCCGGCGGCGGCGGCTCCTCGGCCACAATCCGGCTTTCTTC
CTGCCAGACGCAAGGCTGCC

Downstream 100 bases:

>100_bases
GCGACGCGGTCGAATGCGTCGTCATCGGAGCGGGTGTGGTGGGGCTCGCGGTGGCCAGGGCGCTGGCGATGGAGGGCCGG
GAGGTGCTCGTGCTGGAGGC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MIIYHNPSHRLHAPVHEFFRGERVPCFEKPDRADYVEARLRRQGYALRAPDTDSQAVLARVHAPRYLRFLQDAWPQWLSL
DERNAGVQPFPSVWPVRTLRDDVEPENFVARLGLYSMDNGSPLSEGTWAAAKAGADAAASAAAAVAAGARAAFCCTRPPG
HHAGPDFMGGYCFLNNAAVAAQWLLDAGTARRVAVLDVDYHHGNGTQSIFYDRSDVMCISIHGDPRTEYPFYLGHADETG
AGPGAGFNFNIPLPAGTAFPDWLGALDRACARVEECGAQALVVPLGLDTFEGDPISRFTLSSPDFIEVGARLAGLGLPTV
FVLEGGYAAAELGVNAVNVLEGFERVAGGAGPKGRP

Sequences:

>Translated_356_residues
MIIYHNPSHRLHAPVHEFFRGERVPCFEKPDRADYVEARLRRQGYALRAPDTDSQAVLARVHAPRYLRFLQDAWPQWLSL
DERNAGVQPFPSVWPVRTLRDDVEPENFVARLGLYSMDNGSPLSEGTWAAAKAGADAAASAAAAVAAGARAAFCCTRPPG
HHAGPDFMGGYCFLNNAAVAAQWLLDAGTARRVAVLDVDYHHGNGTQSIFYDRSDVMCISIHGDPRTEYPFYLGHADETG
AGPGAGFNFNIPLPAGTAFPDWLGALDRACARVEECGAQALVVPLGLDTFEGDPISRFTLSSPDFIEVGARLAGLGLPTV
FVLEGGYAAAELGVNAVNVLEGFERVAGGAGPKGRP
>Mature_356_residues
MIIYHNPSHRLHAPVHEFFRGERVPCFEKPDRADYVEARLRRQGYALRAPDTDSQAVLARVHAPRYLRFLQDAWPQWLSL
DERNAGVQPFPSVWPVRTLRDDVEPENFVARLGLYSMDNGSPLSEGTWAAAKAGADAAASAAAAVAAGARAAFCCTRPPG
HHAGPDFMGGYCFLNNAAVAAQWLLDAGTARRVAVLDVDYHHGNGTQSIFYDRSDVMCISIHGDPRTEYPFYLGHADETG
AGPGAGFNFNIPLPAGTAFPDWLGALDRACARVEECGAQALVVPLGLDTFEGDPISRFTLSSPDFIEVGARLAGLGLPTV
FVLEGGYAAAELGVNAVNVLEGFERVAGGAGPKGRP

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI153085395, Length=192, Percent_Identity=34.8958333333333, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI17158039, Length=229, Percent_Identity=31.8777292576419, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI30795202, Length=229, Percent_Identity=31.8777292576419, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI30795204, Length=233, Percent_Identity=30.4721030042918, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI148539870, Length=208, Percent_Identity=33.1730769230769, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI169234807, Length=208, Percent_Identity=33.1730769230769, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI13128864, Length=190, Percent_Identity=34.2105263157895, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI20070354, Length=327, Percent_Identity=25.6880733944954, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI8923769, Length=308, Percent_Identity=25.3246753246753, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI62750349, Length=195, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI62750347, Length=195, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI226529806, Length=326, Percent_Identity=24.2331288343558, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI13128860, Length=236, Percent_Identity=25.4237288135593, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073088, Length=171, Percent_Identity=26.9005847953216, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI293336691, Length=247, Percent_Identity=22.6720647773279, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=237, Percent_Identity=32.4894514767932, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI193206283, Length=237, Percent_Identity=32.4894514767932, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17540332, Length=237, Percent_Identity=32.4894514767932, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537347, Length=225, Percent_Identity=30.2222222222222, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193209491, Length=144, Percent_Identity=34.0277777777778, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17534739, Length=334, Percent_Identity=25.4491017964072, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17561978, Length=278, Percent_Identity=24.4604316546763, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508561, Length=237, Percent_Identity=24.8945147679325, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25154020, Length=129, Percent_Identity=31.7829457364341, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25154022, Length=129, Percent_Identity=31.7829457364341, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=228, Percent_Identity=32.4561403508772, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325141, Length=90, Percent_Identity=41.1111111111111, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323999, Length=279, Percent_Identity=24.0143369175627, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281360899, Length=233, Percent_Identity=33.4763948497854, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24642144, Length=233, Percent_Identity=33.4763948497854, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24642142, Length=233, Percent_Identity=33.4763948497854, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24642146, Length=233, Percent_Identity=33.4763948497854, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360799, Length=225, Percent_Identity=32.8888888888889, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24641720, Length=225, Percent_Identity=32.8888888888889, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281360801, Length=162, Percent_Identity=36.4197530864198, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24657891, Length=274, Percent_Identity=26.2773722627737, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24644244, Length=273, Percent_Identity=24.5421245421245, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 38216; Mature: 38216

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIYHNPSHRLHAPVHEFFRGERVPCFEKPDRADYVEARLRRQGYALRAPDTDSQAVLAR
CEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHH
VHAPRYLRFLQDAWPQWLSLDERNAGVQPFPSVWPVRTLRDDVEPENFVARLGLYSMDNG
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCEECCCC
SPLSEGTWAAAKAGADAAASAAAAVAAGARAAFCCTRPPGHHAGPDFMGGYCFLNNAAVA
CCCCCCCCHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEECCHHHH
AQWLLDAGTARRVAVLDVDYHHGNGTQSIFYDRSDVMCISIHGDPRTEYPFYLGHADETG
HHHHHCCCCCCEEEEEEEEEECCCCCCEEEECCCCEEEEEECCCCCCCCCEEECCCCCCC
AGPGAGFNFNIPLPAGTAFPDWLGALDRACARVEECGAQALVVPLGLDTFEGDPISRFTL
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEC
SSPDFIEVGARLAGLGLPTVFVLEGGYAAAELGVNAVNVLEGFERVAGGAGPKGRP
CCCCHHHHHHHHHCCCCCEEEEEECCCEEHHHCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIIYHNPSHRLHAPVHEFFRGERVPCFEKPDRADYVEARLRRQGYALRAPDTDSQAVLAR
CEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHH
VHAPRYLRFLQDAWPQWLSLDERNAGVQPFPSVWPVRTLRDDVEPENFVARLGLYSMDNG
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCEECCCC
SPLSEGTWAAAKAGADAAASAAAAVAAGARAAFCCTRPPGHHAGPDFMGGYCFLNNAAVA
CCCCCCCCHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEECCHHHH
AQWLLDAGTARRVAVLDVDYHHGNGTQSIFYDRSDVMCISIHGDPRTEYPFYLGHADETG
HHHHHCCCCCCEEEEEEEEEECCCCCCEEEECCCCEEEEEECCCCCCCCCEEECCCCCCC
AGPGAGFNFNIPLPAGTAFPDWLGALDRACARVEECGAQALVVPLGLDTFEGDPISRFTL
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEC
SSPDFIEVGARLAGLGLPTVFVLEGGYAAAELGVNAVNVLEGFERVAGGAGPKGRP
CCCCHHHHHHHHHCCCCCEEEEEECCCEEHHHCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]