Click here to switch to the map view.

The map label for this gene is lhgO [H]

Identifier: 120611122

GI number: 120611122

Start: 2675112

End: 2676215

Strand: Direct

Name: lhgO [H]

Synonym: Aave_2451

Alternate gene names: 120611122

Gene position: 2675112-2676215 (Clockwise)

Preceding gene: 120611121

Following gene: 120611123

Centisome position: 49.98

GC content: 69.93

Gene sequence:

>1104_bases
ATGAGCGACGCGGTCGAATGCGTCGTCATCGGAGCGGGTGTGGTGGGGCTCGCGGTGGCCAGGGCGCTGGCGATGGAGGG
CCGGGAGGTGCTCGTGCTGGAGGCCGCAGGGGCCATCGGCACTGGCACGAGCTCGCGCAACAGCGAGGTCATCCACGCGG
GCATCTACTATCCGCAGGGCTCGCTCAAGGCGCGGCTGTGCGTGCAGGGCAGGGAGCTCCTGTATGCCTACTGCGCGCAG
CGCGGGGTACCGCATCGCCGGTGCGGCAAGCTCATCGTCGCCACGTCGTCTTCGCAGTTCGCATCGCTCGATGGCATCGC
GGCGCGCGCGCGGGCCAACGGTGTGTCCGACCTGCAGCGCCTCGGCCGTGACGAGGCCGTGGCGCTCGAGCCGGCCCTCG
CATGTGCCGGTGCGCTATTGTCGCCCAGCACGGGCATCGTGGACAGCCACGCGCTCATGCTGGCACTGCAGGGGGATCTG
GAGCACGCTGGCGGCATCGTGGCACTCAACTCCGCTTTCTCCGCGGCGCAGTGCGGGTCGGACGGTATCCTGCTGCAGGC
CGAGGACGGCACGAAGCTGCTCGCCCGCTGTGTCATCAACGCGGCCGGTCTGCAGGCGCCGGCGGTGGCTCGCCGTTTCG
CGGGCATGCGGCACGACATGGTGCCGGCGGCCTACTACGCCAAGGGAAGCTACTTCTCGTACTCCGGCCGGGCACCGTTT
TCGCGGCTGGTCTATCCCGTGCCCGAGGCGGCAGGCCTGGGCGTGCACCTGACCCTCGATCTCGGAGGGCAGGCCAGGTT
CGGCCCGGACGTGGAATGGGTCTCGGAAAGCGGCGATCTGGCGGTGGATCCCGCACGTGGCCAGGCGTTCTATGCAGAGG
TGCGGAAGTACTGGCCGGCTTTGCAGGACGGGGCGCTCCAGCCTGCCTACACGGGCATGCGTCCCAAGATCCACGGACCG
CACGAGCCGGCCGCGGATTTCGTGGTCCAGGGCCCGGGGGTGCATGGGGTGCCGGGGCTGGTGCATCTGTACGGCATCGA
ATCGCCCGGGCTCACCAGTTGCCTGGCGATCGCGGAATACGTCACGGCCGCTGCGCGCGGCTGA

Upstream 100 bases:

>100_bases
TCGAAGGCGGATACGCGGCTGCCGAACTGGGGGTGAACGCAGTCAACGTGCTCGAGGGCTTCGAGCGCGTGGCGGGCGGT
GCCGGACCGAAAGGGCGGCC

Downstream 100 bases:

>100_bases
GGGCTCCGCGGCGGGCTGTGGCTTCGCGCTTCATCGTGGCCGGTAATATGGGACATCCGCCTACAGCCGACCTGGGAGGG
GCGGATTACCTTTGGGTTCT

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSDAVECVVIGAGVVGLAVARALAMEGREVLVLEAAGAIGTGTSSRNSEVIHAGIYYPQGSLKARLCVQGRELLYAYCAQ
RGVPHRRCGKLIVATSSSQFASLDGIAARARANGVSDLQRLGRDEAVALEPALACAGALLSPSTGIVDSHALMLALQGDL
EHAGGIVALNSAFSAAQCGSDGILLQAEDGTKLLARCVINAAGLQAPAVARRFAGMRHDMVPAAYYAKGSYFSYSGRAPF
SRLVYPVPEAAGLGVHLTLDLGGQARFGPDVEWVSESGDLAVDPARGQAFYAEVRKYWPALQDGALQPAYTGMRPKIHGP
HEPAADFVVQGPGVHGVPGLVHLYGIESPGLTSCLAIAEYVTAAARG

Sequences:

>Translated_367_residues
MSDAVECVVIGAGVVGLAVARALAMEGREVLVLEAAGAIGTGTSSRNSEVIHAGIYYPQGSLKARLCVQGRELLYAYCAQ
RGVPHRRCGKLIVATSSSQFASLDGIAARARANGVSDLQRLGRDEAVALEPALACAGALLSPSTGIVDSHALMLALQGDL
EHAGGIVALNSAFSAAQCGSDGILLQAEDGTKLLARCVINAAGLQAPAVARRFAGMRHDMVPAAYYAKGSYFSYSGRAPF
SRLVYPVPEAAGLGVHLTLDLGGQARFGPDVEWVSESGDLAVDPARGQAFYAEVRKYWPALQDGALQPAYTGMRPKIHGP
HEPAADFVVQGPGVHGVPGLVHLYGIESPGLTSCLAIAEYVTAAARG
>Mature_366_residues
SDAVECVVIGAGVVGLAVARALAMEGREVLVLEAAGAIGTGTSSRNSEVIHAGIYYPQGSLKARLCVQGRELLYAYCAQR
GVPHRRCGKLIVATSSSQFASLDGIAARARANGVSDLQRLGRDEAVALEPALACAGALLSPSTGIVDSHALMLALQGDLE
HAGGIVALNSAFSAAQCGSDGILLQAEDGTKLLARCVINAAGLQAPAVARRFAGMRHDMVPAAYYAKGSYFSYSGRAPFS
RLVYPVPEAAGLGVHLTLDLGGQARFGPDVEWVSESGDLAVDPARGQAFYAEVRKYWPALQDGALQPAYTGMRPKIHGPH
EPAADFVVQGPGVHGVPGLVHLYGIESPGLTSCLAIAEYVTAAARG

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=271, Percent_Identity=31.3653136531365, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI87082148, Length=377, Percent_Identity=26.790450928382, Blast_Score=121, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17565764, Length=404, Percent_Identity=30.1980198019802, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24585081, Length=251, Percent_Identity=34.2629482071713, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38004; Mature: 37873

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAVECVVIGAGVVGLAVARALAMEGREVLVLEAAGAIGTGTSSRNSEVIHAGIYYPQG
CCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCC
SLKARLCVQGRELLYAYCAQRGVPHRRCGKLIVATSSSQFASLDGIAARARANGVSDLQR
CCEEEEEHHHHHHHHHHHHHCCCCHHHHCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHH
LGRDEAVALEPALACAGALLSPSTGIVDSHALMLALQGDLEHAGGIVALNSAFSAAQCGS
CCCCCEEEECHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCHHHCCC
DGILLQAEDGTKLLARCVINAAGLQAPAVARRFAGMRHDMVPAAYYAKGSYFSYSGRAPF
CCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHEEECCCEEEECCCCCH
SRLVYPVPEAAGLGVHLTLDLGGQARFGPDVEWVSESGDLAVDPARGQAFYAEVRKYWPA
HHHEECCCCCCCCCEEEEEEECCCCCCCCCHHEECCCCCEEECCCCCHHHHHHHHHHCCH
LQDGALQPAYTGMRPKIHGPHEPAADFVVQGPGVHGVPGLVHLYGIESPGLTSCLAIAEY
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHH
VTAAARG
HHHHCCC
>Mature Secondary Structure 
SDAVECVVIGAGVVGLAVARALAMEGREVLVLEAAGAIGTGTSSRNSEVIHAGIYYPQG
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCC
SLKARLCVQGRELLYAYCAQRGVPHRRCGKLIVATSSSQFASLDGIAARARANGVSDLQR
CCEEEEEHHHHHHHHHHHHHCCCCHHHHCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHH
LGRDEAVALEPALACAGALLSPSTGIVDSHALMLALQGDLEHAGGIVALNSAFSAAQCGS
CCCCCEEEECHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCHHHCCC
DGILLQAEDGTKLLARCVINAAGLQAPAVARRFAGMRHDMVPAAYYAKGSYFSYSGRAPF
CCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHEEECCCEEEECCCCCH
SRLVYPVPEAAGLGVHLTLDLGGQARFGPDVEWVSESGDLAVDPARGQAFYAEVRKYWPA
HHHEECCCCCCCCCEEEEEEECCCCCCCCCHHEECCCCCEEECCCCCHHHHHHHHHHCCH
LQDGALQPAYTGMRPKIHGPHEPAADFVVQGPGVHGVPGLVHLYGIESPGLTSCLAIAEY
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHH
VTAAARG
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]