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The map label for this gene is soxR [H]

Identifier: 120610950

GI number: 120610950

Start: 2505702

End: 2506256

Strand: Direct

Name: soxR [H]

Synonym: Aave_2276

Alternate gene names: 120610950

Gene position: 2505702-2506256 (Clockwise)

Preceding gene: 120610946

Following gene: 120610954

Centisome position: 46.81

GC content: 74.77

Gene sequence:

>555_bases
ATGCCGCCAGCCTCCCGCCATGCCCCCCCGTCCGCCACCCCCGGCGCATCCATCCGTCCGGCCGCCGAGGCCCGTTCCCG
CCGGCCCGGCCGTGCCGACGTTCCCGAACTCACGGTGGGCGAGGTCGCCGAACGCAGCGGGCTGGCCGTATCGGCCCTGC
ATTTCTACGAATCCAAGGGCCTGATCGCCAGCGTGCGCAGCGCCGGCAACCAGCGCCGCTATCCGCGCTCCGTGCTGCGG
CGCGTGGCCGTGATCAAGATCGCGCAGCGCATGGGCCTGCCGCTGGCGACCATCGCGGGCGCCCTGCAGGCCCTGCCCGA
AGGCCGCACGCCCACCGTGGCCGACTGGCGGCGCCTGTCGGCCGCCTGGCGCGAGGAACTCGACGAACGCATCGCCACGC
TCACGCGCCTGCGTGACCAGCTCGATGGCTGCATCGGTTGCGGCTGTCTCTCGTTGCGCGCCTGTCCGCTGCGCAACCCG
GACGACGCCCTGGGCGCGGAGGGGGCGGGTCCGCATTTCTCCCCCGACCCGGCCGCGCGCCGGCGGACACGCTGA

Upstream 100 bases:

>100_bases
GACGCCGTGGGGCGGCGACCGCATGCCCTGCAGTATGGAACCTCAACTAAACTTGAGGTCAACTGCTTTTTCCATCCCAT
TTCCGCCACCCCGCCGAGCC

Downstream 100 bases:

>100_bases
CCCTCCGCGGCCCCGGCTGTCCGCGCTGCCGGGCCTGCGAAAGGCGGGGCCTGGAAAACTTCAGGACGCGGCGGGCGGCC
CGCCGCCCGTGGAGCCGGTC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MPPASRHAPPSATPGASIRPAAEARSRRPGRADVPELTVGEVAERSGLAVSALHFYESKGLIASVRSAGNQRRYPRSVLR
RVAVIKIAQRMGLPLATIAGALQALPEGRTPTVADWRRLSAAWREELDERIATLTRLRDQLDGCIGCGCLSLRACPLRNP
DDALGAEGAGPHFSPDPAARRRTR

Sequences:

>Translated_184_residues
MPPASRHAPPSATPGASIRPAAEARSRRPGRADVPELTVGEVAERSGLAVSALHFYESKGLIASVRSAGNQRRYPRSVLR
RVAVIKIAQRMGLPLATIAGALQALPEGRTPTVADWRRLSAAWREELDERIATLTRLRDQLDGCIGCGCLSLRACPLRNP
DDALGAEGAGPHFSPDPAARRRTR
>Mature_183_residues
PPASRHAPPSATPGASIRPAAEARSRRPGRADVPELTVGEVAERSGLAVSALHFYESKGLIASVRSAGNQRRYPRSVLRR
VAVIKIAQRMGLPLATIAGALQALPEGRTPTVADWRRLSAAWREELDERIATLTRLRDQLDGCIGCGCLSLRACPLRNPD
DALGAEGAGPHFSPDPAARRRTR

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=140, Percent_Identity=67.8571428571429, Blast_Score=198, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 19754; Mature: 19623

Theoretical pI: Translated: 11.49; Mature: 11.49

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPASRHAPPSATPGASIRPAAEARSRRPGRADVPELTVGEVAERSGLAVSALHFYESKG
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCC
LIASVRSAGNQRRYPRSVLRRVAVIKIAQRMGLPLATIAGALQALPEGRTPTVADWRRLS
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
AAWREELDERIATLTRLRDQLDGCIGCGCLSLRACPLRNPDDALGAEGAGPHFSPDPAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCHHHH
RRTR
CCCC
>Mature Secondary Structure 
PPASRHAPPSATPGASIRPAAEARSRRPGRADVPELTVGEVAERSGLAVSALHFYESKG
CCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCC
LIASVRSAGNQRRYPRSVLRRVAVIKIAQRMGLPLATIAGALQALPEGRTPTVADWRRLS
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
AAWREELDERIATLTRLRDQLDGCIGCGCLSLRACPLRNPDDALGAEGAGPHFSPDPAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCHHHH
RRTR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9045804; 10984043 [H]