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The map label for this gene is fghA [H]

Identifier: 120610868

GI number: 120610868

Start: 2415074

End: 2415943

Strand: Reverse

Name: fghA [H]

Synonym: Aave_2194

Alternate gene names: 120610868

Gene position: 2415943-2415074 (Counterclockwise)

Preceding gene: 120610869

Following gene: 120610867

Centisome position: 45.13

GC content: 70.23

Gene sequence:

>870_bases
GTGCCCGGCCTGGATCTGCTGAGCGAGCACGCCTGCTTCGGCGGCTCCCAGCGCTTCTACCGGCATTCCTCCGTGGAAAT
CGGCCTCCCGATGAAGTTCGGGGTGTACCTCCCGCCCGCGGCGCTGCGCGAACCCGGGCGCAAGGTGCCCACGCTGATGT
ACCTCGCGGGGCTGACCTGCACCGAGGAAACCTTCATGATCAAGGCGGGCGCCCAGCGCTTCGCCGCCGAACGGGGCATC
GCCCTCATCTCGCCCGACACCAGCCCGCGCGACCCGCAGGCCGAGTCCTTGGAGGGCGCCAACACCGAGTGGGACTTCGG
CATCGGGGCCGGCTTCTACCTCGACGCCACCGAGGAGCCGTGGCAGCGCCACTGGCGCATGGAAAGCTACCTCATCGAGG
AGCTGATCCCGCTGCTGGGGCGCGTGCTGCCGATCGACACGGCGCGCCTGGGCCTCATGGGCCACTCCATGGGCGGCCAC
GGCGCGATCACGCTGGCCCTGCGCCATCCCGGCGTGTTCCGCTCGCTCTCGGCCATCGCGCCGATCTGCGCGGCCTCCCA
GTGCGCCTGGGGCGACAAGGCCTTCCGCCGCTACTTCGGGACGTCCTGCAAGACCTGGCAGGCGCACGACGCCACCGTGC
TCATGCAGCGCCAGCCCGCGGTGCCCTACCCCGACGGCATCCTGGTGGACCAGGGCATGGCGGATGCCTTCCTGGCCGAA
CAGCTGCACCCCCACGTGTTCGAGGCGGCATGCGCGCTGATCAAGCAGCCGCTCACCCTGCGCCGGCACGCGGATTACGA
CCACGGCTATTACTTCATCCAGACGGTGATCGGCGACCACGTCGCCCACCACGCCGACCGGCTGGGCTGA

Upstream 100 bases:

>100_bases
GCGATTCCGATCCACAGCCATGACCTACCAACCCATTGAACCTCCCGACGACGTGAAGGCCGCCCTCGAGGCGGCCGCGC
GCAGGCCCCGCGCCGCCCAG

Downstream 100 bases:

>100_bases
CGCCCGCCCCTCCCGCGGCCGCGGGCCTGGTCCACACGCGCCTCCAGGCCCGGCCCCGGCGCGCGGGGGGGAGGGGATGC
GCGCATTCACGCGGCCGGCA

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MPGLDLLSEHACFGGSQRFYRHSSVEIGLPMKFGVYLPPAALREPGRKVPTLMYLAGLTCTEETFMIKAGAQRFAAERGI
ALISPDTSPRDPQAESLEGANTEWDFGIGAGFYLDATEEPWQRHWRMESYLIEELIPLLGRVLPIDTARLGLMGHSMGGH
GAITLALRHPGVFRSLSAIAPICAASQCAWGDKAFRRYFGTSCKTWQAHDATVLMQRQPAVPYPDGILVDQGMADAFLAE
QLHPHVFEAACALIKQPLTLRRHADYDHGYYFIQTVIGDHVAHHADRLG

Sequences:

>Translated_289_residues
MPGLDLLSEHACFGGSQRFYRHSSVEIGLPMKFGVYLPPAALREPGRKVPTLMYLAGLTCTEETFMIKAGAQRFAAERGI
ALISPDTSPRDPQAESLEGANTEWDFGIGAGFYLDATEEPWQRHWRMESYLIEELIPLLGRVLPIDTARLGLMGHSMGGH
GAITLALRHPGVFRSLSAIAPICAASQCAWGDKAFRRYFGTSCKTWQAHDATVLMQRQPAVPYPDGILVDQGMADAFLAE
QLHPHVFEAACALIKQPLTLRRHADYDHGYYFIQTVIGDHVAHHADRLG
>Mature_288_residues
PGLDLLSEHACFGGSQRFYRHSSVEIGLPMKFGVYLPPAALREPGRKVPTLMYLAGLTCTEETFMIKAGAQRFAAERGIA
LISPDTSPRDPQAESLEGANTEWDFGIGAGFYLDATEEPWQRHWRMESYLIEELIPLLGRVLPIDTARLGLMGHSMGGHG
AITLALRHPGVFRSLSAIAPICAASQCAWGDKAFRRYFGTSCKTWQAHDATVLMQRQPAVPYPDGILVDQGMADAFLAEQ
LHPHVFEAACALIKQPLTLRRHADYDHGYYFIQTVIGDHVAHHADRLG

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=287, Percent_Identity=49.1289198606272, Blast_Score=282, Evalue=3e-76,
Organism=Escherichia coli, GI1786551, Length=286, Percent_Identity=42.3076923076923, Blast_Score=241, Evalue=4e-65,
Organism=Escherichia coli, GI1788477, Length=288, Percent_Identity=44.4444444444444, Blast_Score=228, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17510185, Length=287, Percent_Identity=43.205574912892, Blast_Score=234, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6322393, Length=301, Percent_Identity=36.8770764119601, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI45551932, Length=287, Percent_Identity=43.9024390243902, Blast_Score=249, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24648347, Length=287, Percent_Identity=43.9024390243902, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31927; Mature: 31796

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLDLLSEHACFGGSQRFYRHSSVEIGLPMKFGVYLPPAALREPGRKVPTLMYLAGLTC
CCCHHHHHHHHCCCCCHHHHCCCCEEECCCEECCCCCCCHHHHCCCCCCCHHHHHHCCCC
TEETFMIKAGAQRFAAERGIALISPDTSPRDPQAESLEGANTEWDFGIGAGFYLDATEEP
CCCCEEEEHHHHHHHHHCCEEEECCCCCCCCCCHHHCCCCCCCCCCCCCCCEEECCCCCH
WQRHWRMESYLIEELIPLLGRVLPIDTARLGLMGHSMGGHGAITLALRHPGVFRSLSAIA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCCEEEEEEECCCHHHHHHHHH
PICAASQCAWGDKAFRRYFGTSCKTWQAHDATVLMQRQPAVPYPDGILVDQGMADAFLAE
HHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCHHHHHHH
QLHPHVFEAACALIKQPLTLRRHADYDHGYYFIQTVIGDHVAHHADRLG
HHCHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PGLDLLSEHACFGGSQRFYRHSSVEIGLPMKFGVYLPPAALREPGRKVPTLMYLAGLTC
CCHHHHHHHHCCCCCHHHHCCCCEEECCCEECCCCCCCHHHHCCCCCCCHHHHHHCCCC
TEETFMIKAGAQRFAAERGIALISPDTSPRDPQAESLEGANTEWDFGIGAGFYLDATEEP
CCCCEEEEHHHHHHHHHCCEEEECCCCCCCCCCHHHCCCCCCCCCCCCCCCEEECCCCCH
WQRHWRMESYLIEELIPLLGRVLPIDTARLGLMGHSMGGHGAITLALRHPGVFRSLSAIA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCCCEEEEEEECCCHHHHHHHHH
PICAASQCAWGDKAFRRYFGTSCKTWQAHDATVLMQRQPAVPYPDGILVDQGMADAFLAE
HHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCHHHHHHH
QLHPHVFEAACALIKQPLTLRRHADYDHGYYFIQTVIGDHVAHHADRLG
HHCHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]